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Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 28305

Special Issue Editor

Dr. Verónica Gómez-Gil

E-Mail Website
Guest Editor
CIBER-BBN, Networking Biomedical Research Centre on Bioengineering, Biomaterials and Nanomedicine, University of Alcalá, Madrid, Spain
Interests: tissue repair; biomaterials; tissue regeneration; peritoneum; peritoneal adhesions; wound healing; abdominal mesh; growth factors; omentum; mesothelial cells

Special Issue Information

Dear Colleagues,

Biomaterials represent an essential tool in the fields of Tissue Repair and Tissue Engineering. They have been proved as an adequate and successful approach to be employed for different therapeutic purposes in diverse anatomical areas, providing the support needed for tissue defects repairing. The use of a foreign material into an organism involves a series of challenges that require careful consideration to avoid adverse effects that could lead to the failure of the repairing strategy. This, together with an increasingly in-depth knowledge of the in vivo repairing mechanisms, has led to the development of novel biomaterials that can adapt to the defect as a proper biocompatible scaffold.

This Special Issue will focus on the design, development and assessment of novel biomaterials to be used in the repair of tissue defects or as part of Tissue Engineering therapies. Manuscripts assessing the efficiency, safety, biocompatibility and biomaterial-to-cell and/or biomaterial-to-host tissue interaction of novel materials as well as their integration process into the recipient tissue are particularly appreciated.

The topics of interest include but are not limited to: novel biomaterials design and manufacturing for Tissue Engineering, new synthesis strategies for biomaterials, smart biomaterials development, analysis of biological and mechanical properties of biomaterials, host immune response to biomaterials and integration of biomaterials into the host tissue.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, short communications and reviews are all welcomed.

Dr. Verónica Gómez-Gil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • Biocompatibility
  • Biomaterial-host tissue interaction
  • 3D scaffolds
  • Tissue Engineering
  • Regenerative medicine
  • Immune response
  • Foreign body reaction
  • Biomaterial-induced inflammation
  • Post-implant fibrosis
  • Biodegradation
  • Surgical implants
  • Biological matrices
  • Cytocompatibility
  • Materials functionalization

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Published Papers (6 papers)

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Research

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18 pages, 3224 KiB  
Article
Early Immune Response in Foreign Body Reaction Is Implant/Material Specific
by Nicolas Söhling, Muriel Ondreka, Kerstin Kontradowitz, Tobias Reichel, Ingo Marzi and Dirk Henrich
Materials 2022, 15(6), 2195; https://doi.org/10.3390/ma15062195 - 16 Mar 2022
Cited by 10 | Viewed by 2443
Abstract
The design of novel biomaterials should directly influence the host-immune system and steer it towards high biocompatibility. To date, new implants/materials have been tested for biocompatibility in vitro in cell cultures and in vivo in animal models. The current methods do not reflect [...] Read more.
The design of novel biomaterials should directly influence the host-immune system and steer it towards high biocompatibility. To date, new implants/materials have been tested for biocompatibility in vitro in cell cultures and in vivo in animal models. The current methods do not reflect reality (cell cultures) or are very time-consuming and deliver results only after weeks (animal model). In this proof-of-concept study, the suitability of a Whole Blood Stimulation Assay (WBSA) in combination with a Protein Profiler Array (PPA), as a readily available and cost-effective screening tool, was investigated. Three different biomaterials based on poly(lactic-co-glycolic acid (PLGA), calcium sulphate/-carbonate (CS) and poly(methyl methacrylate) (PMMA) were exposed to native whole blood from three volunteers and subsequently screened with a PPA. Individual reproducible protein profiles could be detected for all three materials after 24 h of incubation. The most intense reaction resulted from the use of PLGA, followed by CS. If even marginal differences in implants can be reflected in protein profiles, the combination of WBSA and PPA could serve as an early biocompatibility screening tool in the development of novel biomaterials. This may also lead to a reduction in costs and the amount of animal testing required. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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26 pages, 6678 KiB  
Article
Architecture-Promoted Biomechanical Performance-Tuning of Tissue-Engineered Constructs for Biological Intervertebral Disc Replacement
by Gernot Lang, Katja Obri, Babak Saravi, Aldo R. Boccaccini, Anton Früh, Michael Seidenstücker, Bodo Kurz, Hagen Schmal and Bernd Rolauffs
Materials 2021, 14(10), 2692; https://doi.org/10.3390/ma14102692 - 20 May 2021
Cited by 5 | Viewed by 2836
Abstract
Background: Biological approaches to intervertebral disc (IVD) restoration and/or regeneration have become of increasing interest. However, the IVD comprises a viscoelastic system whose biological replacement remains challenging. The present study sought to design load-sharing two-component model systems of circular, nested, concentric elements reflecting [...] Read more.
Background: Biological approaches to intervertebral disc (IVD) restoration and/or regeneration have become of increasing interest. However, the IVD comprises a viscoelastic system whose biological replacement remains challenging. The present study sought to design load-sharing two-component model systems of circular, nested, concentric elements reflecting the nucleus pulposus and annulus fibrosus. Specifically, we wanted to investigate the effect of architectural design variations on (1) model system failure loads when testing the individual materials either separately or homogeneously mixed, and (2) also evaluate the potential of modulating other mechanical properties of the model systems. Methods: Two sets of softer and harder biomaterials, 0.5% and 5% agarose vs. 0.5% agarose and gelatin, were used for fabrication. Architectural design variations were realized by varying ring geometries and amounts while keeping the material composition across designs comparable. Results: Variations in the architectural design, such as lamellar width, number, and order, combined with choosing specific biomaterial properties, strongly influenced the biomechanical performance of IVD constructs. Biomechanical characterization revealed that the single most important parameter, in which the model systems vastly exceeded those of the individual materials, was failure load. The model system failure loads were 32.21- and 84.11-fold higher than those of the agarose materials and 55.03- and 2.14-fold higher than those of the agarose and gelatin materials used for system fabrication. The compressive strength, dynamic stiffness, and viscoelasticity of the model systems were always in the range of the individual materials. Conclusions: Relevant architecture-promoted biomechanical performance-tuning of tissue-engineered constructs for biological IVD replacement can be realized by slight modifications in the design of constructs while preserving the materials’ compositions. Minimal variations in the architectural design can be used to precisely control structure–function relations for IVD constructs rather than choosing different materials. These fundamental findings have important implications for efficient tissue-engineering of IVDs and other load-bearing tissues, as potential implants need to withstand high in situ loads. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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Review

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16 pages, 1178 KiB  
Review
New Insights into the Application of 3D-Printing Technology in Hernia Repair
by Bárbara Pérez-Köhler, Selma Benito-Martínez, Verónica Gómez-Gil, Marta Rodríguez, Gemma Pascual and Juan Manuel Bellón
Materials 2021, 14(22), 7092; https://doi.org/10.3390/ma14227092 - 22 Nov 2021
Cited by 14 | Viewed by 3606
Abstract
Abdominal hernia repair using prosthetic materials is among the surgical interventions most widely performed worldwide. These materials, or meshes, are implanted to close the hernial defect, reinforcing the abdominal muscles and reestablishing mechanical functionality of the wall. Meshes for hernia repair are made [...] Read more.
Abdominal hernia repair using prosthetic materials is among the surgical interventions most widely performed worldwide. These materials, or meshes, are implanted to close the hernial defect, reinforcing the abdominal muscles and reestablishing mechanical functionality of the wall. Meshes for hernia repair are made of synthetic or biological materials exhibiting multiple shapes and configurations. Despite the myriad of devices currently marketed, the search for the ideal mesh continues as, thus far, no device offers optimal tissue repair and restored mechanical performance while minimizing postoperative complications. Additive manufacturing, or 3D-printing, has great potential for biomedical applications. Over the years, different biomaterials with advanced features have been successfully manufactured via 3D-printing for the repair of hard and soft tissues. This technological improvement is of high clinical relevance and paves the way to produce next-generation devices tailored to suit each individual patient. This review focuses on the state of the art and applications of 3D-printing technology for the manufacture of synthetic meshes. We highlight the latest approaches aimed at developing improved bioactive materials (e.g., optimizing antibacterial performance, drug release, or device opacity for contrast imaging). Challenges, limitations, and future perspectives are discussed, offering a comprehensive scenario for the applicability of 3D-printing in hernia repair. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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24 pages, 5157 KiB  
Review
Polymer Hernia Repair Materials: Adapting to Patient Needs and Surgical Techniques
by Marta Rodríguez, Verónica Gómez-Gil, Bárbara Pérez-Köhler, Gemma Pascual and Juan Manuel Bellón
Materials 2021, 14(11), 2790; https://doi.org/10.3390/ma14112790 - 24 May 2021
Cited by 19 | Viewed by 6293
Abstract
Biomaterials and their applications are perhaps among the most dynamic areas of research within the field of biomedicine. Any advance in this topic translates to an improved quality of life for recipient patients. One application of a biomaterial is the repair of an [...] Read more.
Biomaterials and their applications are perhaps among the most dynamic areas of research within the field of biomedicine. Any advance in this topic translates to an improved quality of life for recipient patients. One application of a biomaterial is the repair of an abdominal wall defect whether congenital or acquired. In the great majority of cases requiring surgery, the defect takes the form of a hernia. Over the past few years, biomaterials designed with this purpose in mind have been gradually evolving in parallel with new developments in the different surgical techniques. In consequence, the classic polymer prosthetic materials have been the starting point for structural modifications or new prototypes that have always strived to accommodate patients’ needs. This evolving process has pursued both improvements in the wound repair process depending on the implant interface in the host and in the material’s mechanical properties at the repair site. This last factor is important considering that this site—the abdominal wall—is a dynamic structure subjected to considerable mechanical demands. This review aims to provide a narrative overview of the different biomaterials that have been gradually introduced over the years, along with their modifications as new surgical techniques have unfolded. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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45 pages, 4428 KiB  
Review
Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering
by Motaharesadat Hosseini and Masoud Mozafari
Materials 2020, 13(14), 3072; https://doi.org/10.3390/ma13143072 - 9 Jul 2020
Cited by 61 | Viewed by 5107
Abstract
Submicron biomaterials have recently been found with a wide range of applications for biomedical purposes, mostly due to a considerable decrement in size and an increment in surface area. There have been several attempts to use innovative nanoscale biomaterials for tissue repair and [...] Read more.
Submicron biomaterials have recently been found with a wide range of applications for biomedical purposes, mostly due to a considerable decrement in size and an increment in surface area. There have been several attempts to use innovative nanoscale biomaterials for tissue repair and tissue regeneration. One of the most significant metal oxide nanoparticles (NPs), with numerous potential uses in future medicine, is engineered cerium oxide (CeO2) nanoparticles (CeONPs), also known as nanoceria. Although many advancements have been reported so far, nanotoxicological studies suggest that the nanomaterial’s characteristics lie behind its potential toxicity. Particularly, physicochemical properties can explain the positive and negative interactions between CeONPs and biosystems at molecular levels. This review represents recent advances of CeONPs in biomedical engineering, with a special focus on tissue engineering and regenerative medicine. In addition, a summary report of the toxicity evidence on CeONPs with a view toward their biomedical applications and physicochemical properties is presented. Considering the critical role of nanoengineering in the manipulation and optimization of CeONPs, it is expected that this class of nanoengineered biomaterials plays a promising role in the future of tissue engineering and regenerative medicine. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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24 pages, 1118 KiB  
Review
Extracellular Matrix-Derived Hydrogels as Biomaterial for Different Skeletal Muscle Tissue Replacements
by Daniele Boso, Edoardo Maghin, Eugenia Carraro, Mattia Giagante, Piero Pavan and Martina Piccoli
Materials 2020, 13(11), 2483; https://doi.org/10.3390/ma13112483 - 29 May 2020
Cited by 41 | Viewed by 6579
Abstract
Recently, skeletal muscle represents a complex and challenging tissue to be generated in vitro for tissue engineering purposes. Several attempts have been pursued to develop hydrogels with different formulations resembling in vitro the characteristics of skeletal muscle tissue in vivo. This review article [...] Read more.
Recently, skeletal muscle represents a complex and challenging tissue to be generated in vitro for tissue engineering purposes. Several attempts have been pursued to develop hydrogels with different formulations resembling in vitro the characteristics of skeletal muscle tissue in vivo. This review article describes how different types of cell-laden hydrogels recapitulate the multiple interactions occurring between extracellular matrix (ECM) and muscle cells. A special attention is focused on the biochemical cues that affect myocytes morphology, adhesion, proliferation, and phenotype maintenance, underlining the importance of topographical cues exerted on the hydrogels to guide cellular orientation and facilitate myogenic differentiation and maturation. Moreover, we highlight the crucial role of 3D printing and bioreactors as useful platforms to finely control spatial deposition of cells into ECM based hydrogels and provide the skeletal muscle native-like tissue microenvironment, respectively. Full article
(This article belongs to the Special Issue Recent Advances in Novel Biomaterials for Tissue Repair and Tissue Engineering)
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