Anti-Obesity Drugs and Beyond

A special issue of Medicines (ISSN 2305-6320).

Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 5293

Special Issue Editor


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Guest Editor
1. Decommissioning Technology Research Division, Korea Atomic Energy Research Institute (KAERI), 989-111 Daedukdaero, Yuseong, Daejeon 34057, Republic of Korea
2. Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeonbuk 56212, Republic of Korea
3. Quantum Energy Chemical Engineering, University of Science and Technology, 217, Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea
Interests: radiochemistry; radiation chemistry; nanomaterials; nanotechnology; nuclear energy; decommissioning and decontamination science and technology; environmental science and technology; radioactive isotopes; radiation; chemical engineering; separation technology; catalysis; biotechnology; education; sustainability; chemosensors
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Special Issue Information

Dear Colleagues,

Obesity is one of the leading preventable causes of death worldwide, with increasing prevalence in adults and children. The World Health Organization (WHO) rates it as one of the most serious public health problems of the twenty-first century.

The aim of this Special Issue is for the better understanding, treatment, and prevention of obesity to improve the lives of those affected, and thereby to reduce the incidence of obesity-related diseases. We want to contribute to the cure and education of obesity through the sharing of scientific information on the latest developments in obesity among members of Korean Society for the Study of Obesity and other international societies. The journal publishes articles covering all aspects of obesity, in particular drug discovery, lipid metabolism, screening strategy, assay development, enzymes, public health, and Korean food. Nutritional, exercise, psychological, and public education aspects are also included in the studies.

This Special Issue includes research papers on the basics and medicine of obesity and obesity-related diseases, as well as the specific applications of chemistry, such as screening strategy and assay, biochemistry and biotechnology, genetics, and public education study. We think that solving the problems of obesity will be accompanied by various aspects of social problems in this special issue. The types of articles published include original articles, editorials, case reports, reviews, short communications, and letters to the editor.

Dr. Changhyun Roh
Guest Editor

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Keywords

  • obesity
  • natural product
  • Korean medicine
  • lipid
  • drug
  • food
  • public health
  • prevention
  • education

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Published Papers (1 paper)

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Review

15 pages, 3865 KiB  
Review
Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors
by Christian Carpéné, Nathalie Boulet, Alice Chaplin and Josep Mercader
Medicines 2019, 6(1), 9; https://doi.org/10.3390/medicines6010009 - 15 Jan 2019
Cited by 23 | Viewed by 4626
Abstract
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper-containing amine oxidases (AOC) and lysyl oxidases [...] Read more.
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper-containing amine oxidases (AOC) and lysyl oxidases (LOX). All are expressed in adipose tissue, including a semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) strongly present on the adipocyte surface. Methods: Previously, irreversible MAO inhibitors have been reported to limit food intake and/or fat extension in rodents; however, their use for the treatment of depressed patients has not revealed a clear anti-obesity action. Semicarbazide and other molecules inhibiting SSAO/VAP-1 also reduce adiposity in obese rodents. Results: Recently, a LOX inhibitor and a subtype-selective MAO inhibitor have been shown to limit fattening in high-fat diet-fed rats. Phenelzine, which inhibits MAO and AOC, limits adipogenesis in cultured preadipocytes and impairs lipogenesis in mature adipocytes. When tested in rats or mice, phenelzine reduces food intake and/or fat accumulation without cardiac adverse effects. Novel amine oxidase inhibitors have been recently characterized in a quest for promising anti-inflammatory or anti-cancer approaches; however, their capacity to mitigate obesity has not been studied so far. Conclusions: The present review of the diverse effects of amine oxidase inhibitors impairing adipocyte differentiation or limiting excessive fat accumulation indicates that further studies are needed to reveal their potential anti-obesity properties. Full article
(This article belongs to the Special Issue Anti-Obesity Drugs and Beyond)
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