Novel Agents and Complementary Therapies for Chronic Pain

A special issue of Medicines (ISSN 2305-6320).

Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 18426

Special Issue Editor


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Guest Editor
Monash Biomedicine Discovery Institute and Department of Physiology; Monash University, VIC 3800 Melbourne; Australia
Interests: Neuropathic pain, neural circuits, spinal cord, neuropharmacology

Special Issue Information

Dear Colleagues,

Chronic pain is a major global health burden that affects more than 20% of the population, resulting in an enormous socio-economic burden. This debilitating condition often manifests as hypersensitivity to sensory input, so a normally innocuous stimulus can be painful or a moderately noxious stimulus produces excessive pain. Analgesics that are currently in use for chronic pain only provide pain relief in a small proportion of patients. Long-term use of many pain therapeutics is limited due to the development of tolerance, addiction and side effects such as drowsiness, respiratory depression and gastrointestinal ulceration. There is an urgent need for safer and more effective drugs for chronic pain management. This Special Issue of Medicines will focus on novel agents and complementary therapies for the treatment of chronic pain conditions. Research articles and reviews relating to potential therapeutic agents or therapies to treat pain, including those in animal models or humans, will be covered.

Prof. Dr. Wendy L. Imlach
Guest Editor

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Keywords

  • Pain
  • Nociception
  • Analgesic
  • Chronic or pathological pain
  • Painkillers
  • Novel therapeutics

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Published Papers (1 paper)

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Review

16 pages, 1000 KiB  
Review
Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain
by Pawan Bista and Wendy L. Imlach
Medicines 2019, 6(3), 91; https://doi.org/10.3390/medicines6030091 - 22 Aug 2019
Cited by 43 | Viewed by 18113
Abstract
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic and therapeutic challenges to healthcare [...] Read more.
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic and therapeutic challenges to healthcare providers and often require multiple therapeutic approaches for pain reduction. This review will provide the overview of pathophysiology in peripheral and central nociceptive circuits that are involved in neuropathic pain conditions involving the trigeminal nerve and the current therapeutics that are used to treat these disorders. Recent advances in treatment of trigeminal pain, including novel therapeutics that target ion channels and receptors, gene therapy and monoclonal antibodies that have shown great promise in preclinical studies and clinical trials will also be described. Full article
(This article belongs to the Special Issue Novel Agents and Complementary Therapies for Chronic Pain)
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