Hypothalamic Regulation of Whole-Body Energy Metabolism: From Physiology to Pathophysiology
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: closed (5 September 2024) | Viewed by 2114
Special Issue Editor
Interests: obesity; neuroinflammation; metabolism; metabolic disorders; neuropsychiatry disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The regulation of energy homeostasis is a highly integrated and regulated process that aims to maintain the stability of body energy stores over time. The hypothalamus is the primary center for the regulation of the whole-body energy metabolism. Thermoregulation, satiety, sleep, sexual behavior, and emotional control seem to be modulated in part by the hypothalamus. Hypothalamic neural cells respond to peripheral signals controlling food intake, energy expenditure, glucose, and lipid metabolism in a homeostatic way, and also integrate with limbic and cortical areas to coordinate the hedonic responses to food.
Defective crosstalk between the hypothalamus and other brain regions as well as with peripheral organs contributes to the development of a number of chronic disorders, including obesity, type 2 diabetes, and cardiovascular diseases. This Special Issue highlights the hypothalamus as a central regulator of whole-body energy metabolism. Specific research areas include, but are not limited to, the identification of molecular mechanisms of hypothalamic physiology and pathophysiology in the regulation of food intake, energy expenditure and liver metabolism, the role of microbiota and the gut–brain axis in energy homeostasis, obesity-induced neuroinflammation and dysregulation of brain metabolism, and molecular targets for obesity treatment. Manuscripts dealing with other pertinent challenging issues are also highly encouraged.
Dr. Joana M. Gaspar
Guest Editor
Manuscript Submission Information
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Keywords
- obesity
- whole-body energy homeostasis
- metabolic regulation
- hypothalamus
- food intake
- neuroinflammation
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