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Metabolites
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Melatonin and Vitamin: Perspectives for Diseases and Health
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Melatonin and Vitamin: Perspectives for Diseases and Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 4926

Special Issue Editor

Dr. Konrad Kleszczyński

E-Mail Website
Guest Editor
Department of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany
Interests: dermatoendocrinology; melanoma; melanogenesis; photobiology; cutaneous cells; mitochondria; oxidative stress; melatonin and its metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, numerous studies have provided new insights into the new biological capacities and health-related or clinical applications for melatonin, vitamin D as well as its metabolites. Namely, both substances have been widely documented as differentiative ones with beneficial impact such as the biological regulation of circadian rhythms, sleep, mood, reproduction, tumor growth, immune response, and neurodegenerative processes for melatonin or being a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, phosphate, and many other biological effects for vitamin D.

The Special Issue on “Melatonin and Vitamin: Perspectives for Diseases and Health” will include manuscripts collecting the latest scientific findings in terms of molecular mechanisms of action and biological function of melatonin and vitamin D as well as their metabolites or homologues. Papers aim to improve our understanding of the biological meaningful of these substances as well as involved signalling pathways. Original experimental research, review articles, and commentary articles on this and related topics are invited.

Dr. Konrad Kleszczyński
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melatonin
  • metabolites of melatonin
  • vitamin D
  • vitamins
  • melanoma
  • skin diseases
  • cell signalling
  • mitochondria
  • dermatoendocrinology
  • skin therapy

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Published Papers (2 papers)

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Research

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15 pages, 3239 KiB  
Article
Ultraviolet Radiation-Induced Mitochondrial Disturbances Are Attenuated by Metabolites of Melatonin in Human Epidermal Keratinocytes
by Chantal E. Holtkamp, Dawid Warmus, Klaudia Bonowicz, Maciej Gagat, Kinga Linowiecka, Agnieszka Wolnicka-Glubisz, Russel J. Reiter, Markus Böhm, Andrzej T. Slominski, Kerstin Steinbrink and Konrad Kleszczyński
Metabolites 2023, 13(7), 861; https://doi.org/10.3390/metabo13070861 - 20 Jul 2023
Cited by 7 | Viewed by 2008
Abstract
Melatonin (N-acetyl-5-methoxytryptamine) is recognized as an effective antioxidant produced by the pineal gland, brain and peripheral organs, which also has anti-inflammatory, immunomodulatory, and anti-tumour capacities. Melatonin has been reported as a substance that counteracts ultraviolet radiation B (UVB)-induced intracellular disturbances. Nevertheless, [...] Read more.
Melatonin (N-acetyl-5-methoxytryptamine) is recognized as an effective antioxidant produced by the pineal gland, brain and peripheral organs, which also has anti-inflammatory, immunomodulatory, and anti-tumour capacities. Melatonin has been reported as a substance that counteracts ultraviolet radiation B (UVB)-induced intracellular disturbances. Nevertheless, the mechanistic actions of related molecules including its kynurenic derivatives (N1-acetyl-N2-formyl-5-methoxykynurenine (AFMK)), its indolic derivatives (6-hydroxymelatonin (6(OH)MEL) and 5-methoxytryptamine (5-MT)) and its precursor N-acetylserotonin (NAS) are only poorly understood. Herein, we treated human epidermal keratinocytes with UVB and assessed the protective effect of the studied substances in terms of the maintenance of mitochondrial function or their radical scavenging capacity. Our results show that UVB caused the significant elevation of catalase (CAT) and superoxide dismutase (Mn-SOD), the dissipation of mitochondrial transmembrane potential (mtΔΨ), a reduction in ATP synthesis, and the enhanced release of cytochrome c into cytosol, leading subsequently to UVB-mediated activation of the caspases and apoptosis (appearance of sub-G1 population). Our findings, combined with data reported so far, indicate the counteracting and beneficial actions of melatonin and its molecular derivatives against these deleterious changes within mitochondria. Therefore, they define a path to the development of novel strategies delaying mitochondrial aging and promoting the well-being of human skin. Full article
(This article belongs to the Special Issue Melatonin and Vitamin: Perspectives for Diseases and Health)
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Review

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20 pages, 1181 KiB  
Review
Melatonin and TGF-β-Mediated Release of Extracellular Vesicles
by Klaudia Piekarska, Klaudia Bonowicz, Alina Grzanka, Łukasz M. Jaworski, Russel J. Reiter, Andrzej T. Slominski, Kerstin Steinbrink, Konrad Kleszczyński and Maciej Gagat
Metabolites 2023, 13(4), 575; https://doi.org/10.3390/metabo13040575 - 18 Apr 2023
Cited by 5 | Viewed by 2388
Abstract
The immune system, unlike other systems, must be flexible and able to “adapt” to fully cope with lurking dangers. The transition from intracorporeal balance to homeostasis disruption is associated with activation of inflammatory signaling pathways, which causes modulation of the immunology response. Chemotactic [...] Read more.
The immune system, unlike other systems, must be flexible and able to “adapt” to fully cope with lurking dangers. The transition from intracorporeal balance to homeostasis disruption is associated with activation of inflammatory signaling pathways, which causes modulation of the immunology response. Chemotactic cytokines, signaling molecules, and extracellular vesicles act as critical mediators of inflammation and participate in intercellular communication, conditioning the immune system’s proper response. Among the well-known cytokines allowing for the development and proper functioning of the immune system by mediating cell survival and cell-death-inducing signaling, the tumor necrosis factor α (TNF-α) and transforming growth factor β (TGF-β) are noteworthy. The high bloodstream concentration of those pleiotropic cytokines can be characterized by anti- and pro-inflammatory activity, considering the powerful anti-inflammatory and anti-oxidative stress capabilities of TGF-β known from the literature. Together with the chemokines, the immune system response is also influenced by biologically active chemicals, such as melatonin. The enhanced cellular communication shows the relationship between the TGF-β signaling pathway and the extracellular vesicles (EVs) secreted under the influence of melatonin. This review outlines the findings on melatonin activity on TGF-β-dependent inflammatory response regulation in cell-to-cell communication leading to secretion of the different EV populations. Full article
(This article belongs to the Special Issue Melatonin and Vitamin: Perspectives for Diseases and Health)
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