Metabolic Effects of Foregut Surgery in the Management of Obesity and Diabetes

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 988

Special Issue Editors


E-Mail Website
Guest Editor
Division of Foregut Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea
Interests: bariatric surgery; onco-metabolic surgery; gastric cancer

E-Mail Website
Guest Editor
Division of Foregut Surgery, Korea University College of Medicine, Seoul 02841, Republic of Korea
Interests: obesity; bariatric surgery; type 2 diabetes; onco-metabolic surgery

Special Issue Information

Dear Colleagues,

Metabolomic research has highlighted that foregut surgery (bariatric surgery or gastric cancer surgery) is responsible for metabolic effects and immediately alters various metabolic pathways. Investigations for discovering biomarkers predicting the outcome of foregut surgery are in the preliminary stages. Extensive research should be performed to identify significant metabolites and as well as to develop models and validate their predictive performance prior to clinical application. Preoperative prediction of metabolic effects induced by foregut surgery will enable better selection of surgical candidates and improve pre- and postoperative management of patients. Understanding short- and long-term systemic adaptations to foregut surgery may provide insights into the mechanisms underlying weight loss and comorbidities improvement and can lead to the discovery of new drug targets for obesity or diabetes treatment.

Prof. Dr. Sungsoo Park
Dr. Yeongkeun Kwon
Guest Editors

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Keywords

  • bariatric surgery
  • metabolic surgery
  • gastric cancer surgery
  • metabolomics
  • biomarker
  • obesity
  • type 2 diabetes

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Published Papers (1 paper)

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Research

10 pages, 933 KiB  
Article
Association Between Indole-3-Pyruvic Acid and Change in Fat-Free Mass Relative to Weight Loss in Patients Undergoing Sleeve Gastrectomy
by Eunhye Seo, Yeongkeun Kwon and Sungsoo Park
Metabolites 2024, 14(8), 444; https://doi.org/10.3390/metabo14080444 - 11 Aug 2024
Viewed by 680
Abstract
Sleeve gastrectomy typically leads to weight loss, including a reduction in fat-free mass (FFM). Studies have shown significant FFM loss within 1 year after the procedure but with individual variations. This study aimed to assess whether preoperative amino acid metabolite levels can predict [...] Read more.
Sleeve gastrectomy typically leads to weight loss, including a reduction in fat-free mass (FFM). Studies have shown significant FFM loss within 1 year after the procedure but with individual variations. This study aimed to assess whether preoperative amino acid metabolite levels can predict FFM changes following sleeve gastrectomy. This study involved 42 patients. Body weight, fat mass (FM), and FFM were measured preoperatively and 3, 6, and 12 months postoperatively. All participants experienced weight loss, FM reduction, and FFM decrease for up to 3 months after surgery. However, the following distinct groups emerged from 3 to 6 months postoperatively: one showed FFM gain relative to weight loss, whereas the other exhibited continued FFM reduction relative to weight loss. This trend persisted for up to 12 months postoperatively and became more pronounced. The group with FFM gain had lower preoperative BMI and higher levels of indole-3-pyruvic acid (IPyA). Logistic regression and ROC curve analyses confirmed IPyA’s ability to predict FFM gain between 3 and 6 months after sleeve gastrectomy, with a useful cutoff value of 20.205. Preoperative IPyA levels were associated with FFM gain relative to weight loss in the 3 to 6 months following sleeve gastrectomy. These findings suggest that IPyA may be a potential predictor for FFM changes during this period. Full article
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