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Metabolites
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Metabolomics Analysis of the Relationship between Intestinal Microorganisms and Human...
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Metabolomics Analysis of the Relationship between Intestinal Microorganisms and Human Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 10150

Special Issue Editors

Dr. Raja Ganesan

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Guest Editor
Research Professor, Institute for Liver and Digestive Diseases, College of Medicine, Hallym University, Chuncheon, Korea
Interests: metabolomics; metabolomics profiling; gut microbiome; immunology
Special Issues, Collections and Topics in MDPI journals
Dr. Abilash Valsala Gopalakrishnan

E-Mail Website
Guest Editor
Department Biomedical Sciences, School of Bio Sciences and Technology, VIT, Vellore, Tamil Nadu, India
Interests: human disease; genetics and molecular biology; toxicology; metabolomics; gut microbiome
Special Issues, Collections and Topics in MDPI journals
Dr. Arumugam Balasubramanian

E-Mail Website
Guest Editor
Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Interests: human disease; molecular biology; immunology; bone; metabolomics

Special Issue Information

Dear Colleagues,

We aim to provide unique phenotypic evidence on the human diseases such as alcoholic liver diseases, non- alcoholic liver diseases, cardiovascular disease, cancer, gut dysbiosis, metabolic inflammation, etc,. Metabolomics investigates the biological properties of metabolome profile in their pathways that have been routinely applied as tools for clinical therapeutics. The small molecules or metabolites can be discovered and underlie the key therapy to human cancers and avoid cancer burden. Metabolomics is a great tool for biomarker discovery and validation. The applications of micobial metabolomics have continually been growing which can refinement of methods for measurement, analysis, and understanding of complex data sets of human disease.

Metabolomic signatures provide a big scope of application in human health and disease. Metabolomics have been technologically advanced and act as a division of systems biology. Metabolomics profiling analysis has two different methods such as targeted profiling, and untargeted profiling. Physico-chemical processes and microbial metabolomics in various intestinal microorganisms and human diseases will be focus in this special issues. By focusing various analytical and molecular technologies on the human microorganisms and diseases can now increased.

Prof. Dr. Raja Ganesan
Dr. Abilash Valsala Gopalakrishnan
Dr. Arumugam Balasubramanian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • metabonomics
  • targeted profiling
  • untargeted profiling
  • gut intestine
  • microbiota
  • metabolites
  • biochemistry
  • cheminformatics
  • pattern recognition analysis

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Published Papers (2 papers)

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Review

20 pages, 1084 KiB  
Review
Role of Metabolism and Metabolic Pathways in Prostate Cancer
by Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Reshma Murali, Abhijit Dey, Balachandar Vellingiri and Raja Ganesan
Metabolites 2023, 13(2), 183; https://doi.org/10.3390/metabo13020183 - 25 Jan 2023
Cited by 6 | Viewed by 3232
Abstract
Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells modify their metabolism in response to an excessive [...] Read more.
Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells modify their metabolism in response to an excessive intake of nutrients to facilitate advancement. Metabolic syndrome (MetS) is inextricably linked to the carcinogenic progression of PCa, which heightens the severity of the disease. It is hypothesized that changes in the metabolism of the mitochondria contribute to the onset of PCa. The studies of particular alterations in the progress of PCa are best accomplished by examining the metabolome of prostate tissue. Due to the inconsistent findings written initially, additional epidemiological research is required to identify whether or not MetS is an aspect of PCa. There is a correlation between several risk factors and the progression of PCa, one of which is MetS. The metabolic symbiosis between PCa cells and the tumor milieu and how this type of crosstalk may aid in the development of PCa is portrayed in this work. This review focuses on in-depth analysis and evaluation of the metabolic changes that occur within PCa, and also aims to assess the effect of metabolic abnormalities on the aggressiveness status and metabolism of PCa. Full article
(This article belongs to the Special Issue Metabolomics Analysis of the Relationship between Intestinal Microorganisms and Human Diseases)
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33 pages, 1053 KiB  
Review
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
by Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Raja Ganesan, Abhijit Dey, Achsha Babu, Kaviyarasi Renu, Balachandar Vellingiri, Gnanasambandan Ramanathan, George Priya Doss C., Nehal Elsherbiny, Amira M. Elsherbini, Alsamman M. Alsamman, Hatem Zayed and Abilash Valsala Gopalakrishnan
Metabolites 2023, 13(1), 129; https://doi.org/10.3390/metabo13010129 - 14 Jan 2023
Cited by 15 | Viewed by 6044
Abstract
As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota [...] Read more.
As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it. Full article
(This article belongs to the Special Issue Metabolomics Analysis of the Relationship between Intestinal Microorganisms and Human Diseases)
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