Advances in Immunotherapeutic Approaches to Diabetes
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 528
Special Issue Editors
2. International Center for T1D, Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Science L. Sacco, University of Milan, 20157 Milan, Italy
3. Division of Endocrinology, ASST Sacco Fatebenefratelli-Sacco, 20157 Milan, Italy
Interests: new immune-based preventive and therapeutic strategies for autoimmune diseases; immunotherapy; type 1 diabetes; transplantation and stem cells to prevent and treat autoimmune diabetes and allograft reject ion
Interests: type 1 diabetes; immunological basis of autoimmune diabetes; stem cells based approach to treat/prevent diabetes and its complications; islet transplantation; immunotherapies; novel immunological pathways to be targeted in type 1 diabetes
Interests: stem cells in type 1 diabetes; autoimmunity and diabetes; regenerative approcahes to treat autoimmune diabetes; immunotherapeutic approaches in type 1 diabetes
Interests: type 1 diabetes and its clinical relevance; gestational diabetes; type 2 diabetes and cardiovascular disease; diabetes technology; clinical trials for diabetes
Special Issue Information
Dear Colleagues,
Immunotherapy represents a promising therapeutic approach in several disease conditions with increasing clinical applications. In autoimmune diabetes some of the strategies explored to reverse or halt beta-cells destruction are antigen-specific therapies, anti-inflammatory therapies, cell-depleting and stem cell-based therapies. A growing number of evidences suggests a role of innate immune system in triggering and sustaining generalized inflammation also in type 2 diabetes. Moreover, immunomodulation is of paramount importance in islet cell and pancreatic transplantation. Although numerous preclinical works suggested the immune system as a potential useful target in the treatment of diabetes, clinical studies have been only partially successful. This special issue of Metabolites is devoted to providing a complete overview of the rationale for the use of immunotherapy in diabetes and updates on preclinical and clinical studies in the field. We therefore invite review manuscripts as well as original manuscripts dealing with identification of novel immune-based approaches/strategies in diabetes, anti-inflammatory cytokines-based therapy, engineering of biomaterials, autoantigen modulation and other relevant issues.
Prof. Paolo Fiorina
Dr. Francesca D'Addio
Dr. Moufida Ben Nasr
Dr. Ida Pastore
Dr. Andrea Mario Bolla
Guest Editors
Manuscript Submission Information
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Keywords
- immunotherapy
- type 1 diabetes
- type 2 diabetes
- autoimmune diabetes
- stem cells therapy
- inflammation
- autoimmunity
- immunomodulation
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