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Metabolites
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Marine Metabolomics Volume 2
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Marine Metabolomics Volume 2

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: closed (15 April 2020) | Viewed by 8581

Special Issue Editor

Dr. RuAngelie Edrada-Ebel

E-Mail Website
Guest Editor
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Interests: marine natural products chemistry; secondary metabolomics; NMR- and MS-based metabolomics; marine biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I would like to invite you to publish your work in this Special Issue on Marine Metabolomics. Metabolomics is a growing branch of “omics” science, which has found its application in marine science.  Marine metabolomics has currently been applied to marine ecology, drug discovery, and marine biotechnology. Metabolomics has become an essential tool in analysing the environmental changes affecting marine macro- and microorganisms. On other hand, metabolomics has been used as a dereplication tool for functional biology to target the discovery of bioactive compounds as well as to optimise their production.  In the search for new potential drugs (e.g., antibiotics, anticancer drugs, drugs targeting metabolic diseases, and agrochemicals) and because of the increasing issues related to the current environmental changes in our oceans, researchers have been trying to develop new metabolomics tools to deal with larger datasets and to relate their metabolomics results to those of other omic tools, such as transcriptomics and genomics. This Special Issue will be a great opportunity to introduce such explorative methodology of data analysis. It intends to put together a compilation of research papers on the advancements on metabolomics in marine science.

Dr. RuAngelie Edrada-Ebel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine metabolomics
  • Marine ecology
  • Marine natural products
  • Drug discovery
  • Marine biotechnology

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Published Papers (2 papers)

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Research

17 pages, 2170 KiB  
Article
Integrative Metabolomics for Assessing the Effect of Insect (Hermetia illucens) Protein Extract on Rainbow Trout Metabolism
by Simon Roques, Catherine Deborde, Laurence Guimas, Yann Marchand, Nadège Richard, Daniel Jacob, Sandrine Skiba-Cassy, Annick Moing and Benoit Fauconneau
Metabolites 2020, 10(3), 83; https://doi.org/10.3390/metabo10030083 - 27 Feb 2020
Cited by 36 | Viewed by 4578
Abstract
Nutrition of high trophic species in aquaculture is faced with the development of sustainable plant-based diets. Insects seem particularly promising for supplementing plant-based diets. However, the complex effect of whole insect meal on fish metabolism is not well understood, and even less is [...] Read more.
Nutrition of high trophic species in aquaculture is faced with the development of sustainable plant-based diets. Insects seem particularly promising for supplementing plant-based diets. However, the complex effect of whole insect meal on fish metabolism is not well understood, and even less is known about insect meal extracts. The purpose of this work was to decipher the metabolic utilization of a plant-based diet supplemented with the gradual addition of an insect protein extract (insect hydrolysate at 0%, 5%, 10% and 15%). 1H-NMR profiling was used to assess metabolites in experimental diets and in fish plasma, liver and muscle. A significant dose-dependent increase in growth and feed efficiency with increasing insect extract amounts was observed. The incremental incorporation of the insect extract in diet had a significant and progressive impact on the profile of dietary soluble compounds and trout metabolome. The metabolites modulated by dietary insect extracts in plasma and tissues were involved in protein and energy metabolism. This was associated with the efficient metabolic use of dietary free amino acids toward protein synthesis through the concomitant supply of balanced free amino acids and energy substrates in muscle. The findings provide new insights into how the dietary food metabolome affects fish metabolism. Full article
(This article belongs to the Special Issue Marine Metabolomics Volume 2)
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15 pages, 2115 KiB  
Article
Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder, Paralichthys olivaceus
by Seonghye Kim, Ahran Kim, Seohee Ma, Wonho Lee, Sujin Lee, Dahye Yoon, Do-Hyung Kim and Suhkmann Kim
Metabolites 2020, 10(1), 3; https://doi.org/10.3390/metabo10010003 - 18 Dec 2019
Cited by 9 | Viewed by 3407
Abstract
Continuous increases in water temperature disturb homeostasis and increase oxidative stress in fish. Glutathione (GSH) is an intracellular antioxidant that helps to relieve stress in animals. In this study, we observed the effect of GSH on olive flounder exposed to high temperature using [...] Read more.
Continuous increases in water temperature disturb homeostasis and increase oxidative stress in fish. Glutathione (GSH) is an intracellular antioxidant that helps to relieve stress in animals. In this study, we observed the effect of GSH on olive flounder exposed to high temperature using serum parameters and NMR-based metabolomics. Based on the results from the first experiment, 20 mg of GSH was chosen as an effective dose with lower infection rates and mortality. Then, fish were divided into Control, Temp (PS injection), and GSH (glutathione injection) groups, and fish in Temp and GSH groups were exposed to temperature fluctuations (20 °C→24 °C→27 °C). In OPLS-DA score plots, Temp group was clearly distinguished from the other groups in the kidney. In the liver, the metabolic patterns of GSH group were close to the Temp group on day 4 and became similar to Control group from day 7. Serum parameters did not change significantly, but the deviation in Temp group was greater than that in GSH group. Metabolite levels that were significantly altered included GSH, lactate, O-phosphocholine, and betaine in the kidney and taurine, glucose, and several amino acids in the liver, which were related to antioxidant activity and energy system. Therefore, GSH supplements could relieve thermal stress influencing metabolic mechanisms in fish. Full article
(This article belongs to the Special Issue Marine Metabolomics Volume 2)
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