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Metabolites
Special Issues
Psoriasis and Its Related Metabolic Complications
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Psoriasis and Its Related Metabolic Complications

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 12420

Special Issue Editor

Prof. Anna Baran

E-Mail Website
Guest Editor
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland
Interests: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Psoriasis is a chronic autoimmune and inflammatory disease affecting 2–4% of the global population. In recent years the viewpoint on the pathogenesis of psoriasis has evolved significantly, but it has yet to be fully elucidated. To date, psoriasis has been regarded as systemic disease closely related to numerous cardiometabolic disorders. Persons with psoriasis have a shortened life expectancy, mainly due to cardiovascular diseases and increased relative risk of mortality in comparison to the general population, which correlates with the severity of the disease. The multidirectional relationship of psoriasis with numerous comorbidities is translated by common genetic or immunological pathways as well as oxidative stress, but also with systemic metabolically driven inflammation which is crucial in psoriasis pathogenesis and consequently leads to the development of atherosclerosis, insulin resistance and further cardiometabolic complications. There have been continuous research efforts searching for novel markers and metabolites to evaluate or screen for cardiometabolic risk in order to enable early detection, followed by more effective and timely lifestyle or more accurate and newer therapeutic interventions.

This Special Issue, “Psoriasis and Its Related Metabolic Complications”, will present the current knowledge on psoriasis and its metabolic comorbidities, with a special emphasis on novel contexts of the pathogenesis, treatment and validation of novel, innovative markers to give readers a deeper understanding of these complex interrelations.

Dr. Anna Baran
Guest Editor

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Keywords

  • psoriasis
  • psoriatic arthritis
  • metabolic diseases
  • genetic and epigenetic factors 
  • markers
  • therapy
  • immunology
  • pathogenesis

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Published Papers (6 papers)

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Research

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16 pages, 2620 KiB  
Article
A Solid-Phase Microextraction—Liquid Chromatography-Mass Spectrometry Method for Analyzing Serum Lipids in Psoriatic Disease
by John Koussiouris, Nikita Looby, Vathany Kulasingam and Vinod Chandran
Metabolites 2023, 13(8), 963; https://doi.org/10.3390/metabo13080963 - 20 Aug 2023
Cited by 4 | Viewed by 1404
Abstract
Approximately 25% of psoriasis patients have an inflammatory arthritis termed psoriatic arthritis (PsA). There is strong interest in identifying and validating biomarkers that can accurately and reliably predict conversion from psoriasis to PsA using novel technologies such as metabolomics. Lipids, in particular, are [...] Read more.
Approximately 25% of psoriasis patients have an inflammatory arthritis termed psoriatic arthritis (PsA). There is strong interest in identifying and validating biomarkers that can accurately and reliably predict conversion from psoriasis to PsA using novel technologies such as metabolomics. Lipids, in particular, are of key interest in psoriatic disease. We sought to develop a liquid chromatography-mass spectrometry (LC-MS) method to be used in conjunction with solid-phase microextraction (SPME) for analyzing fatty acids and similar molecules. A total of 25 chromatographic methods based on published lipid studies were tested on two LC columns. As a proof of concept, serum samples from psoriatic disease patients (n = 27 psoriasis and n = 26 PsA) were processed using SPME and run on the selected LC-MS method. The method that was best for analyzing fatty acids and fatty acid-like molecules was optimized and applied to serum samples. A total of 18 tentatively annotated features classified as fatty acids and other lipid compounds were statistically significant between psoriasis and PsA groups using both multivariate and univariate approaches. The SPME-LC-MS method developed and optimized was capable of detecting fatty acids and similar lipids that may aid in differentiating psoriasis and PsA patients. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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7 pages, 1114 KiB  
Communication
Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
by Julia Nowowiejska, Anna Baran, Justyna Magdalena Hermanowicz, Joanna Mikłosz, Karol Adam Kamiński, Marcin Kondraciuk, Marlena Dubatówka, Dariusz Pawlak and Iwona Flisiak
Metabolites 2022, 12(9), 877; https://doi.org/10.3390/metabo12090877 - 17 Sep 2022
Cited by 3 | Viewed by 1893
Abstract
Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardiometabolic [...] Read more.
Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardiometabolic complications, especially coronary artery disease (CAD). The study involved 56 patients with abovementioned dermatoses and 29 sex- and age-matched volunteers without dermatoses. ANGPTL4 serum concentration was measured by ELISA. ANGPTL4 concentration was statistically significantly higher in patients with LP compared to the control group (p < 0.01); moreover, it was significantly higher than in patients with psoriasis and vitiligo (p < 0.001, p < 0.01, respectively). There was no statistically significant difference in ANGPTL4 concentration between patients with psoriasis or vitiligo and controls. There was no correlation between ANGPTL4 concentration and age or BMI in all study groups. There was a positive correlation between ANGPTL4 concentration and fasting glucose (R = 0.43) and AST activity (R = 0.39) in psoriatic patients and ALT activity in patients with vitiligo (R = 0.44). ANGPTL4 could be a potential marker of metabolic complications in patients with LP, especially CAD. Perhaps patients with LP are more prone to CAD compared to the other two dermatoses, which requires further research. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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14 pages, 1559 KiB  
Article
Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome
by Drahomira Holmannova, Pavel Borsky, Ctirad Andrys, Kvetoslava Hamakova, Eva Cermakova, Gabriela Poctova, Zdenek Fiala, Jindra Smejkalova, Vladimir Blaha and Lenka Borska
Metabolites 2022, 12(8), 688; https://doi.org/10.3390/metabo12080688 - 26 Jul 2022
Cited by 2 | Viewed by 1798
Abstract
Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. [...] Read more.
Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. The main objective of our study was to show the genotoxic potential of chronic inflammation and determine whether the presence of both pathologies increases chromosomal damage compared to psoriasis alone and to evaluate whether there are correlations between selected parameters and chromosomal aberrations in patients with psoriasis and MetS psoriasis. Clinical examination (PASI score and MetS diagnostics according to National Cholesterol Education Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; NCE/ATPIII criteria), biochemical analysis of blood samples (fasting glucose, total cholesterol, low density and high density lipoproteins; LDL, HDL, non-HDL, and triglycerides;TAG), DNA/RNA oxidative damage, and chromosomal aberration test were performed in 41 participants (20 patients with psoriasis without MetS and 21 with MetS and psoriasis). Our results showed that patients with psoriasis without metabolic syndrome (nonMetS) and psoriasis and MetS had a higher rate of chromosomal aberrations than the healthy population for which the limit of spontaneous, natural aberration was <2%. No significant differences in the aberration rate were found between the groups. However, a higher aberration rate (higher than 10%) and four numerical aberrations were documented only in the MetS group. We found no correlations between the number of chromosomal aberrations and the parameters tested except for the correlation between aberrations and HDL levels in nonMetS patients (rho 0.44; p < 0.02). Interestingly, in the MetS group, a higher number of chromosomal aberrations was documented in non-smokers compared to smokers. Data from our current study revealed an increased number of chromosomal aberrations in patients with psoriasis and MetS compared to the healthy population, especially in psoriasis with MetS, which could increase the genotoxic effect of inflammation and the risk of genomic instability, thus increasing the risk of carcinogenesis. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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15 pages, 963 KiB  
Article
Potential Predictive Value of Serum Pentraxin 3 and Paraoxonase 1 for Cardiometabolic Disorders Development in Patients with Psoriasis—Preliminary Data
by Anna Baran, Anna Stepaniuk, Paulina Kiluk, Tomasz W. Kaminski, Magdalena Maciaszek and Iwona Flisiak
Metabolites 2022, 12(7), 580; https://doi.org/10.3390/metabo12070580 - 22 Jun 2022
Cited by 3 | Viewed by 1752
Abstract
Psoriasis is a systemic disease that is linked to cardiometabolic complications. Paraoxonase 1 (PON1) exerts anti-atherogenic properties. Pentraxin 3 (PTX3) is related to heart failure and atherosclerosis. We aimed to evaluate the protein levels in psoriatic patients and explore possible relations with disease [...] Read more.
Psoriasis is a systemic disease that is linked to cardiometabolic complications. Paraoxonase 1 (PON1) exerts anti-atherogenic properties. Pentraxin 3 (PTX3) is related to heart failure and atherosclerosis. We aimed to evaluate the protein levels in psoriatic patients and explore possible relations with disease activity, metaflammation parameters and systemic treatment. Thirty-three patients with plaque-type psoriasis and eleven healthy controls were enrolled in the study. Blood samples were collected before and after three months of therapy with acitretin or methotrexate. Serum proteins levels were evaluated using Bio-Plex 200 System. The mean serum pentraxin 3 level was significantly higher in patients with psoriasis, compared to controls (p < 0.01). Significant negative correlations between PTX3 with triglycerides in overweight patients, with glucose, cholesterol and triglycerides in obese patients, and with cholesterol and triglycerides in severe psoriatics were noted (all p < 0.05). After the treatment, PTX3 significantly decreased (p < 0.05). The mean serum PON1 in psoriatic patients did not differ, compared to the controls (p > 0.05). In psoriatics of normal weight, PON1 correlated negatively with liver enzymes activity (p < 0.05). PTX3 might exert a protective role in terms of cardiometabolic disorders development, especially in overweight and obese or most severe psoriatics. PON1 could serve as an indicator of the liver disorders in psoriasis. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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Review

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11 pages, 953 KiB  
Review
Fatty Acid-Binding Proteins in Psoriasis—A Review
by Julia Nowowiejska, Anna Baran and Iwona Flisiak
Metabolites 2022, 12(9), 833; https://doi.org/10.3390/metabo12090833 - 3 Sep 2022
Cited by 9 | Viewed by 2581
Abstract
Psoriasis is one of the most common skin diseases in dermatological practice. It affects about 1–3% of the general population and is associated with different comorbidities, especially metabolic syndrome. Fatty-acid-binding proteins (FABPs) are a family of cytosolic proteins which are an important link [...] Read more.
Psoriasis is one of the most common skin diseases in dermatological practice. It affects about 1–3% of the general population and is associated with different comorbidities, especially metabolic syndrome. Fatty-acid-binding proteins (FABPs) are a family of cytosolic proteins which are an important link in lipid metabolism and transport; moreover, they have different tissue specificity and properties. So far, ten FABPs have been discovered and seven have been investigated in psoriasis. In this review, we discuss the nature of all FABPs and their role in psoriasis. FABPs have different organ and tissue expression, and hence various functions, and may be markers of different disorders. Considering the concentration of a few of them tends to be elevated in psoriasis, it confirms the current perception of psoriasis as a multiorgan disorder associated with plenty of comorbidities. Some FABPs may be also further investigated as biomarkers of psoriasis organ complications. FABP-1 and FABP-5 may become potential markers of metabolic complications and inflammation in psoriasis. FABP-7 could perhaps be further investigated as an indicator of the neurodegenerative processes in psoriatic patients. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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Other

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8 pages, 1056 KiB  
Brief Report
New Markers for Cardiovascular Disease in Psoriatic Patients: Preliminary Study on Monocyte Phenotype, ADAMTS7, and mTOR Activity
by Khanty Loyola, Claudio Karsulovic, Raúl Cabrera, Claudio Perez and Lía Hojman
Metabolites 2023, 13(1), 116; https://doi.org/10.3390/metabo13010116 - 11 Jan 2023
Cited by 4 | Viewed by 1663
Abstract
Psoriasis is a skin disease with occasional involvement of non-cutaneous territories. Beyond the usual, cardiovascular events are more frequent in these patients and correlate only partially with disease activity, suggesting the presence of other unknown factors. We selected ten psoriatic patients without treatment [...] Read more.
Psoriasis is a skin disease with occasional involvement of non-cutaneous territories. Beyond the usual, cardiovascular events are more frequent in these patients and correlate only partially with disease activity, suggesting the presence of other unknown factors. We selected ten psoriatic patients without treatment in the last year and matched them for age and gender with eleven healthy subjects. Ficoll-extracted mononuclear cells were analyzed with flow cytometry for monocyte surface phenotype markers, intracellular NFκB/inflammasome-dependent interleukins, and chemotaxis receptor CXCR3. Using ELISA, patient serum was evaluated for ADAMTS7 and CXCL10. Inflammatory M1 monocytes showed higher levels of IL-1β and IL-6 in psoriatic patients. M2 monocytes also showed higher levels of intracellular inflammatory cytokines. Nevertheless, IL-6 values were higher compared to other monocytes and IL-1β. The mTORC activation markers ADAMTS7 and S6Rp were higher in psoriatic patients than in healthy controls. In psoriatic patients, serum levels of ADAMTS7 were elevated, and M2 monocytes showed a distinct inflammatory response with higher relative levels of NFκB-dependent IL-6 and less activity of the CXCR3–CXCL10 chemotactic pathway. These data suggest pathways with potential markers for prediction and early detection of cardiovascular risk in psoriatic patients. Full article
(This article belongs to the Special Issue Psoriasis and Its Related Metabolic Complications)
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