Metabolites and Thyroid

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1480

Special Issue Editors


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Guest Editor
Endocrinology and Diabetes Division, Medicine Department, Universidade Federal de São Paulo, Sao Paulo 04022-001, Brazil
Interests: thyroid disorders; thyroid cancer; thyroid eye disease; metabolomics; cardiovascular risk

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Guest Editor
Department of Biological Sciences, Federal University of Sao Paulo, Sao Paulo 05508-000, Brazil
Interests: thyroid physiology and pathology; endocrine disruptors; epigenetics
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Special Issue Information

Dear Colleagues,

As Guest Editors of Metabolites, it is our pleasure to introduce this Special Issue dedicated to the discussion about the connections of thyroid diseases and metabolites. Therefore, this thematic issue aims to delve into the intricacies of thyroid function, its disorders, and the pivotal role of metabolites in thyroid health and disease.

The thyroid gland plays a crucial role in regulating metabolism, growth, and development. Thyroid diseases, which encompass a range of disorders from hypothyroidism to thyroid cancer, affect millions of people worldwide, impacting their quality of life and posing significant health challenges. The intricate interplay between thyroid hormones and metabolites not only governs vital physiological functions but also offers a window into understanding systemic disorders.

Recent advances in the fields of endocrinology, biochemistry, and molecular biology have shed light on the complex mechanisms governing thyroid function and its disorders. These developments have opened new frontiers in the diagnosis, treatment, and management of thyroid diseases. However, despite these advancements, there are still significant gaps in our understanding of the etiology, progression, and management of these conditions.

We invite researchers, clinicians, and scholars to contribute their original research articles, reviews, case studies, and meta-analyses to this Special Issue. Submissions may focus on a wide range of topics, including, but not limited to, the molecular pathways of thyroid hormone synthesis and action, the impact of metabolites on thyroid function, novel diagnostic markers, therapeutic approaches for thyroid disorders, and the epidemiology of thyroid diseases.

Our aim with this Special Issue is to foster a comprehensive understanding of thyroid diseases, encourage interdisciplinary collaborations, and stimulate innovative research in this field. We are particularly interested in contributions that explore the emerging areas of thyroid research, such as the role of gut microbiota in thyroid function, the impact of environmental factors on thyroid health, and the advancements in thyroid imaging and therapeutics.

By bringing together the latest research and perspectives from leading experts in the field, this Special Issue will serve as a valuable resource for researchers, healthcare professionals, and policy makers. It will also provide a platform for discussing the challenges and opportunities in thyroid research and healthcare.

We look forward to receiving your contributions and to advancing our collective knowledge in the fascinating and vital field of thyroid diseases and metabolites.

Dr. Carolina Castro Porto Silva Janovsky
Dr. Caroline Serrano-Nascimento
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • hypothyroidism
  • hyperthyroidism
  • thyroid cancer
  • thyroid function
  • endocrine disruptors
  • lipidomics
  • proteomics

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Published Papers (1 paper)

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Research

11 pages, 875 KiB  
Article
Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil
by Carolina Castro Porto Silva Janovsky, Vandrize Meneghini, William Tebar, Joao Roberto Maciel Martins, José Augusto Sgarbi, Patrícia de Fatima dos Santos Teixeira, Steven R. Jones, Michael J. Blaha, Peter P. Toth, Paulo A. Lotufo, Marcio S. Bittencourt, Raul D. Santos, Itamar S. Santos, Layal Chaker and Isabela M. Bensenor
Metabolites 2024, 14(8), 437; https://doi.org/10.3390/metabo14080437 - 6 Aug 2024
Viewed by 1084
Abstract
The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain amino acids (BCAAs—leucine, isoleucine, and valine) and of alanine [...] Read more.
The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain amino acids (BCAAs—leucine, isoleucine, and valine) and of alanine in the general population. We utilized data from the São Paulo research center of ELSA-Brasil, a longitudinal population-based cohort study. Thyroid parameters included thyroid stimulating hormone (TSH), free T4 and free T3 levels, and the FT4:FT3 ratio. BCAAs and alanine were analyzed on a fully automated NMR platform. The current analysis included euthyroid participants and participants with subclinical hyperthyroidism and hypothyroidism. We used Pearson’s coefficient to quantify the correlation between thyroid-related parameters and amino acids. Linear regression models were performed to analyze whether thyroid parameters were associated with BCAAs and alanine levels. We included 4098 participants (51.3 ± 9.0 years old, 51.5% women) in this study. In the most adjusted model, higher levels of TSH were associated with higher levels of alanine, FT4 levels were inversely associated with isoleucine levels, FT3 levels were statistically significant and positively associated with valine and leucine, and the T3:T4 ratio was positively associated with all amino acids. We observed that subclinical hypothyroidism was positively associated with isoleucine and alanine levels in all models, even after full adjustment. Our findings highlight the association of subclinical hypothyroidism and thyroid-related parameters (including TSH, free T4, free T3, and FT4:FT3 ratio) with BCAAs and alanine. Further studies are needed to explore the mechanisms underlying this association. These insights contribute to our understanding of the influence of thyroid-related parameters on BCAA and alanine metabolism. Full article
(This article belongs to the Special Issue Metabolites and Thyroid)
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