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Metabolites
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Toxicity and Ecotoxicity Mechanisms of Heavy Metals on Human Health...
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Toxicity and Ecotoxicity Mechanisms of Heavy Metals on Human Health and Environment

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 3738

Special Issue Editors

Dr. Rashid Mir

E-Mail Website
Guest Editor
Department of Medical Laboratory Technology, Division of Molecular Biology, University of Tabuk, Tabuk 71491, Saudi Arabia
Interests: biochemistry; molecular biology; cancer research; oxidative stress; cancer therapy; gene expression
Prof. Dr. Marianne Graber

E-Mail Website
Guest Editor
La Rochelle, laboratoire LIENSs UMR CNRS 7266, Bâtiment Marie Curie, Avenue M. Crépeau, CEDEX 1, 17042 La Rochelle, France
Interests: metabolomics; pollution; marine organisms; heavy metals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many metals are essential for living organisms, but at higher doses, they may be toxic and carcinogenic. Metal exposure occurs mainly in occupational settings and through the environmental contamination of drinking water, air pollution and foods, which can result in serious health problems, such as cancer or many others deleterious impacts on metabolism. Arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr) and nickel (Ni) are classified as Group 1 carcinogens by the International Agency for Research on Cancer. Zinc (Zn), copper (Cu) and aluminium (Al) are also frequent costal contaminants, leading to health problems in marine organisms. This Special Issue will elucidate the molecular mechanisms of metal-induced carcinogenesis and other metabolic disorders and will focus on a variety of pathways, including genotoxicity, mutagenesis, oxidative stress, epigenetic modifications such as DNA methylation, histone post-translational modification and alterations in microRNA regulation, competition with essential metal ions, disorders of energy metabolism, amino acid metabolism, osmoregulation, and cancer-related signaling pathways. This Special Issue takes a broader perspective and aims to assist in guiding future research, with respect to the prevention and therapy of metal exposure in living organisms with diseases including cancer, neurotoxicity, cardiovascular disease, chronic disease, coronary artery disease and different metabolic disorders.

Dr. Rashid Mir
Prof. Dr. Marianne Graber
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-induced carcinogenesis
  • genotoxicity
  • mutagenesis
  • oxidative stress
  • epigenetic modifications
  • metabolomics
  • metabolic disorders
  • environmental impacts

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Published Papers (2 papers)

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Research

14 pages, 3268 KiB  
Article
Unveiling Metal Tolerance Mechanisms in Leersia hexandra Swartz under Cr/Ni Co-Pollution by Studying Endophytes and Plant Metabolites
by Mouyixing Chen, Guo Yu, Hui Qiu, Pingping Jiang, Xuemei Zhong and Jie Liu
Metabolites 2024, 14(4), 231; https://doi.org/10.3390/metabo14040231 - 18 Apr 2024
Viewed by 1367
Abstract
Heavy metal pollution poses significant environmental challenges, and understanding how plants and endophytic bacteria interact to mitigate these challenges is of utmost importance. In this study, we investigated the roles of endophytic bacteria, particularly Chryseobacterium and Comamonas, in Leersia hexandra Swartz ( [...] Read more.
Heavy metal pollution poses significant environmental challenges, and understanding how plants and endophytic bacteria interact to mitigate these challenges is of utmost importance. In this study, we investigated the roles of endophytic bacteria, particularly Chryseobacterium and Comamonas, in Leersia hexandra Swartz (L. hexandra) in response to chromium and nickel co-pollution. Our results demonstrated the remarkable tolerance of Chryseobacterium and Comamonas to heavy metals, and their potential to become dominant species in the presence of co-pollution. We observed a close relationship between these endophytic bacteria and the significant differences in metabolites, particularly carbohydrates, flavonoids, and amino acids in L. hexandra. These findings shed light on the potential of endophytic bacteria to promote the production of aspartic acid and other metabolites in plants as a response to abiotic stressors. Furthermore, our study presents a new direction for plant and bioremediation strategies in heavy metal pollution and enhances our understanding of L. hexandra’s mechanisms for heavy metal tolerance. Full article
(This article belongs to the Special Issue Toxicity and Ecotoxicity Mechanisms of Heavy Metals on Human Health and Environment)
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25 pages, 2858 KiB  
Article
Metabolomics-Based Investigation on the Metabolic Changes in Crassostrea gigas Experimentally Exposed to Galvanic Anodes
by Nathalie Imbert-Auvray, Denis Fichet, Pierre-Edouard Bodet, Pascaline Ory, René Sabot, Philippe Refait and Marianne Graber
Metabolites 2023, 13(7), 869; https://doi.org/10.3390/metabo13070869 - 20 Jul 2023
Cited by 1 | Viewed by 1289
Abstract
Cathodic protection is widely used to protect metal structures from corrosion in marine environments using sacrificial galvanic anodes. These anodes, either in Zinc, or preferentially nowadays in Al-Zn-In alloys, are expected to corrode instead of the metal structures. This leads to the release [...] Read more.
Cathodic protection is widely used to protect metal structures from corrosion in marine environments using sacrificial galvanic anodes. These anodes, either in Zinc, or preferentially nowadays in Al-Zn-In alloys, are expected to corrode instead of the metal structures. This leads to the release of dissolved species, Zn2+, Al3+, and In3+, and solid phases such as Al(OH)3. Few studies have been conducted on their effects on marine organisms, and they concluded that further investigations are needed. We therefore evaluated the effects of Zn and Al-Zn-In anodes on oysters stabulated in tanks, under controlled conditions defined through a comparison with those prevailing in a given commercial seaport used as reference. We analyzed the entire metabolome of gills with a non-targeted metabolomic approach HRMS. A modelling study of the chemical species, corresponding to the degradation products of the anodes, likely to be present near the exposed oysters, was also included. We identified 16 and two metabolites modulated by Zn- and Al-Zn-In-anodes, respectively, that were involved in energy metabolism, osmoregulation, oxidative stress, lipid, nucleotide nucleoside and amino acid metabolisms, defense and signaling pathways. The combination of chemical modelling and metabolomic approach, used here for the first time, enlightened the influence of Zn present in the Al-Zn-In anodes. Full article
(This article belongs to the Special Issue Toxicity and Ecotoxicity Mechanisms of Heavy Metals on Human Health and Environment)
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