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Metabolites
Special Issues
Urinary Metabolomic Profiling Analysis and Evaluation
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Urinary Metabolomic Profiling Analysis and Evaluation

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 19175

Special Issue Editor

Prof. Dr. Minoru Miyazato

E-Mail Website
Guest Editor
Department of Systems Physiology, University of the Ryukyus, Okinawa, Japan
Interests: voiding; neurourology; urinary sensing

Special Issue Information

Dear Colleagues,

Improving lifestyle habits is central to preventing lifestyle-related diseases (i.e., metabolic syndrome); however, implementing behavioral changes is challenging. Voiding is the most basic human behavior for maintaining homeostasis, and it can be altered by changes in physical activity, such as body weight, blood pressure, among others. Voiding itself is also a social activity seen in urinary scent marking in male rodents. We have recently reported that voiding problems, such as nocturia, are related to metabolic syndrome and are improved in the early phase of metabolic syndrome onset or improvement. Urine pH, electrolytes (e.g., sodium), and metabolites may be surrogate markers of metabolic syndrome or the related lower urinary tract symptoms, such as overactive bladder. If we can use this urinary metabolomic profiling analysis for personalized care of individuals, we can monitor urine by home-based IoT devices (e.g., smartphone) with feedback advice. In this specific issue, voiding itself or urinary sensing materials related to metabolic syndrome or its related overactive bladder are encouraged for publication.

Prof. Dr. Minoru Miyazato
Guest Editor

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Keywords

  • voiding
  • nocturia
  • metabolic syndrome
  • obesity
  • urine ph
  • urine electrolytes
  • urine sensing
  • social communication
  • behavior change
  • congnition

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Published Papers (5 papers)

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Research

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12 pages, 688 KiB  
Article
Relationship between Urinary Calcium Excretion and Lower Urinary Tract Symptoms
by Tomohiro Matsuo, Hidenori Ito, Kensuke Mitsunari, Kojiro Ohba and Yasuyoshi Miyata
Metabolites 2022, 12(3), 229; https://doi.org/10.3390/metabo12030229 - 5 Mar 2022
Cited by 4 | Viewed by 2954
Abstract
To date, few detailed studies have been conducted on the convenient and useful markers for the prevalence of lower urinary tract symptoms (LUTS), including overactive bladder (OAB) and nocturia. A high level of calcium (Ca) excretion (hypercalciuria) is indicative of lifestyle-related diseases such [...] Read more.
To date, few detailed studies have been conducted on the convenient and useful markers for the prevalence of lower urinary tract symptoms (LUTS), including overactive bladder (OAB) and nocturia. A high level of calcium (Ca) excretion (hypercalciuria) is indicative of lifestyle-related diseases such as hypertension, which are associated with the onset of LUTS. Hence, in this study we attempted to clarify the relationship between urinary Ca excretion and OAB, nocturia, and nocturnal polyuria in adults. The present study showed that patients with hypercalciuria frequently experienced OAB, nocturia, and nocturnal polyuria. In addition, this study revealed that the severity of LUTS is significantly associated with urinary Ca excretion and that hypercalciuria is an important risk factor for OAB, nocturia, and nocturnal polyuria. Full article
(This article belongs to the Special Issue Urinary Metabolomic Profiling Analysis and Evaluation)
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23 pages, 3091 KiB  
Article
1H-Nuclear Magnetic Resonance Analysis of Urine as Diagnostic Tool for Organic Acidemias and Aminoacidopathies
by Ninna Pulido, Johana M. Guevara-Morales, Alexander Rodriguez-López, Álvaro Pulido, Jhon Díaz, Ru Angelie Edrada-Ebel and Olga Y. Echeverri-Peña
Metabolites 2021, 11(12), 891; https://doi.org/10.3390/metabo11120891 - 20 Dec 2021
Cited by 7 | Viewed by 3639
Abstract
The utility of low-resolution 1H-NMR analysis for the identification of biomarkers provided evidence for rapid biochemical diagnoses of organic acidemia and aminoacidopathy. 1H-NMR, with a sensitivity expected for a field strength of 400 MHz at 64 scans was used to establish [...] Read more.
The utility of low-resolution 1H-NMR analysis for the identification of biomarkers provided evidence for rapid biochemical diagnoses of organic acidemia and aminoacidopathy. 1H-NMR, with a sensitivity expected for a field strength of 400 MHz at 64 scans was used to establish the metabolomic urine sample profiles of an infant population diagnosed with small molecule Inborn Errors of Metabolism (smIEM) compared to unaffected individuals. A qualitative differentiation of the 1H-NMR spectral profiles of urine samples obtained from individuals affected by different organic acidemias and aminoacidopathies was achieved in combination with GC–MS. The smIEM disorders investigated in this study included phenylalanine metabolism; isovaleric, propionic, 3-methylglutaconicm and glutaric type I acidemia; and deficiencies in medium chain acyl-coenzyme and holocarboxylase synthase. The observed metabolites were comparable and similar to those reported in the literature, as well as to those detected with higher-resolution NMR. In this study, diagnostic marker metabolites were identified for the smIEM disorders. In some cases, changes in metabolite profiles differentiated post-treatments and follow-ups while allowing for the establishment of different clinical states of a biochemical disorder. In addition, for the first time, a 1H-NMR-based biomarker profile was established for holocarboxylase synthase deficiency spectrum. Full article
(This article belongs to the Special Issue Urinary Metabolomic Profiling Analysis and Evaluation)
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13 pages, 3722 KiB  
Article
l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
by Kanako Matsuoka, Hidenori Akaihata, Junya Hata, Ryo Tanji, Ruriko Honda-Takinami, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Masao Kataoka, Soichiro Ogawa and Yoshiyuki Kojima
Metabolites 2021, 11(11), 778; https://doi.org/10.3390/metabo11110778 - 14 Nov 2021
Cited by 4 | Viewed by 3616
Abstract
Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary [...] Read more.
Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility. Full article
(This article belongs to the Special Issue Urinary Metabolomic Profiling Analysis and Evaluation)
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Review

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39 pages, 3036 KiB  
Review
Therapeutic and Toxic Effects of Valproic Acid Metabolites
by Natalia A. Shnayder, Violetta V. Grechkina, Aiperi K. Khasanova, Elena N. Bochanova, Evgenia A. Dontceva, Marina M. Petrova, Azat R. Asadullin, German A. Shipulin, Kuanysh S. Altynbekov, Mustafa Al-Zamil and Regina F. Nasyrova
Metabolites 2023, 13(1), 134; https://doi.org/10.3390/metabo13010134 - 16 Jan 2023
Cited by 29 | Viewed by 5409
Abstract
Valproic acid (VPA) and its salts are psychotropic drugs that are widely used in neurological diseases (epilepsy, neuropathic pain, migraine, etc.) and psychiatric disorders (schizophrenia, bipolar affective disorder, addiction diseases, etc.). In addition, the indications for the appointment of valproate have been expanding [...] Read more.
Valproic acid (VPA) and its salts are psychotropic drugs that are widely used in neurological diseases (epilepsy, neuropathic pain, migraine, etc.) and psychiatric disorders (schizophrenia, bipolar affective disorder, addiction diseases, etc.). In addition, the indications for the appointment of valproate have been expanding in recent years in connection with the study of new mechanisms of action of therapeutic and toxic metabolites of VPA in the human body. Thus, VPA is considered a component of disease-modifying therapy for multiple tumors, neurodegenerative diseases (Huntington’s disease, Parkinson’s disease, Duchenne progressive dystrophy, etc.), and human immunodeficiency syndrome. The metabolism of VPA is complex and continues to be studied. Known pathways of VPA metabolism include: β-oxidation in the tricarboxylic acid cycle (acetylation); oxidation with the participation of cytochrome P-450 isoenzymes (P-oxidation); and glucuronidation. The complex metabolism of VPA explains the diversity of its active and inactive metabolites, which have therapeutic, neutral, or toxic effects. It is known that some active metabolites of VPA may have a stronger clinical effect than VPA itself. These reasons explain the relevance of this narrative review, which summarizes the results of studies of blood (serum, plasma) and urinary metabolites of VPA from the standpoint of the pharmacogenomics and pharmacometabolomics. In addition, a new personalized approach to assessing the cumulative risk of developing VPA-induced adverse reactions is presented and ways for their correction are proposed depending on the patient’s pharmacogenetic profile and the level of therapeutic and toxic VPA metabolites in the human body fluids (blood, urine). Full article
(This article belongs to the Special Issue Urinary Metabolomic Profiling Analysis and Evaluation)
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Other

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8 pages, 238 KiB  
Project Report
Obesity and Voiding Parameters in a Community-Based Population of Okinawa, Japan: Kumejima Digital Health Project (KDHP)
by Asuka Ashikari, Minoru Miyazato, Koshi Nakamura, Kiyoto Yamashiro, Takehiro Nakamura, Tsugumi Uema, Moriyuki Uehara, Hiroaki Masuzaki, Seiichi Saito, Shiro Maeda, Hajime Ishida and Masayuki Matsushita
Metabolites 2022, 12(5), 468; https://doi.org/10.3390/metabo12050468 - 23 May 2022
Viewed by 2467
Abstract
(1) Background: Evidence has accumulated regarding the etiology of lower urinary tract symptoms associated with obesity and metabolic syndrome. Therefore, the present study aimed to identify which subjectively and objectively measured voiding parameters were associated with obesity in a community-based population. (2) Methods: [...] Read more.
(1) Background: Evidence has accumulated regarding the etiology of lower urinary tract symptoms associated with obesity and metabolic syndrome. Therefore, the present study aimed to identify which subjectively and objectively measured voiding parameters were associated with obesity in a community-based population. (2) Methods: Voiding parameters on a self-administered questionnaire and a digital self-health monitoring system for urine excretion (s-HMSU) were compared between participants with and without obesity, defined as a body mass index ≥ 25 kg/m2 (n = 30 and 29, respectively), from a community in Okinawa, Japan. Logistic regression analysis was employed to calculate the odds ratios of abnormalities in voiding parameters for the obese group, with the non-obese group serving as a reference. (3) Results: The obese group had odds ratios of 5.17 (95% confidence interval: 1.33–20.0) for shortened hours of undisturbed sleep (<302 min) by s-HMSU and 7.65 (1.88–31.1) for nighttime urinary frequency by a questionnaire after adjusting for age and sex. In addition, the obese group had an adjusted odds ratio of 2.27 (0.76–6.78) for decreased maximum bladder capacity (<212 mL) by s-HMSU. (4) Conclusion: the results of the present study suggest that nocturia and shortened hours of undisturbed sleep are signs of obesity. Full article
(This article belongs to the Special Issue Urinary Metabolomic Profiling Analysis and Evaluation)
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