Microfluidics for Biological and Medical Analysis, Detection and Diagnosis

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 856

Special Issue Editors


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Guest Editor
Department of Engineering Science, National Cheng Kung University, Tainan 70101, Taiwan
Interests: microfluidic systems; microfluidic paper-based devices; MEMS fabrication technologies; micro-sensor and computational fluid dynamics simulations
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Guest Editor
Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Interests: MEMS fabrication technologies; bio-MEMS; microfluidic paper-based devices; microfluidic reaction system; application of atmospheric plasma

Special Issue Information

Dear Colleagues,

Microfluidic technology platforms enable the miniaturization and integration of various laboratory functions, offering significant advantages such as reduced sample consumption, enhanced sensitivity, rapid analysis, and portability. The unique phenomena at the small scale of microfluidic technology have generated exciting research and enabled the development of practical applications in recent years. Thus, the use of microfluidic components in biological and medical research has increased, becoming a widely adopted tool. In this Special Issue, we seek research and review articles that highlight recent advances in the application of microfluidic technology, demonstrating its potential impact on detection and diagnostics in biology and medicine. Microfluidic-based devices may also include microfluidic chips, microfluidic paper-based devices, and lab-on-a-chip, lab-on-paper, paper-strips, point-of-care devices. In addition, practical microfluidic technology platforms that exhibit the ability to solve real-world problems are of particular interest.

Prof. Dr. Lung-Ming Fu
Prof. Dr. Che-Hsin Lin
Guest Editors

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Keywords

  • microfluidics
  • microsystems
  • lab-on-a-chip
  • lab-on-paper
  • organ-on-a-chip
  • point-of-care devices
  • biological and medical analysis
  • diagnosis

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Published Papers (1 paper)

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Research

11 pages, 6119 KiB  
Article
Euler Force-Driven Siphon Valve Control for Precise Sequential Release in Centrifugal Microfluidic Chips
by Yu Lu, Hao Shen, Guangyao Chen, Kaichao Yang, Jing Zhang, Liwei Xue, Jianzhen Ou and Liguo Chen
Micromachines 2024, 15(10), 1200; https://doi.org/10.3390/mi15101200 - 27 Sep 2024
Viewed by 657
Abstract
Controlling the fluids in centrifugal microfluidic chips for precise sequential release is critical for multi-step reactions and immunoassays. Currently, the traditional methods of liquid sequential release mainly rely on various types of microvalves, which face the problems of complex operation and high costs. [...] Read more.
Controlling the fluids in centrifugal microfluidic chips for precise sequential release is critical for multi-step reactions and immunoassays. Currently, the traditional methods of liquid sequential release mainly rely on various types of microvalves, which face the problems of complex operation and high costs. Here, this work presents a method for driving liquid release using the Euler force. Under continuous acceleration and deceleration, the centrifugal and Euler forces can transfer the liquid from the sample chamber to the collection chamber. The liquid sequential release mechanism based on the Euler force was analyzed, which showed that the angular acceleration is key to the liquid release. Then, the geometrical parameters affecting the angular acceleration of complete release were investigated and simulated. Finally, based on the relationship between the geometrical parameters of the connecting channels and the angular acceleration of complete release, a simple and precise sequential release structure was designed, which allowed for a sequential and stable transfer of the liquid into the reaction chamber. The results showed that the proposed method is capable of transferring liquid, and its simple structure, low manufacturing cost, and ease of operation enable precise sequential liquid release in centrifugal microfluidic platforms. Full article
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