Nanomechanical Biosensors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (20 December 2018) | Viewed by 6040

Special Issue Editors


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Guest Editor
IMM-CSIC Isaac Newton 8, PTM-28760 Tres Cantos, Madrid, Spain
Interests: bionanomechanics; cell mechanics; nanomechanical mass spectrometry; optomechanics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
IMM-CSIC Isaac Newton 8, PTM-28760 Tres Cantos, Madrid, Spain
Interests: ultra high sensitivity biosensors; plasmonics; nanomechanics; cancer diagnostics; HIV diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many fundamental biological processes, such as cellular signaling, biomolecular interactions, biomolecular machinery, and disease manifest as or arise from mechanical responses such as piconewton scale forces, subnanometer-scale displacements, elasticity changes, and mass variations.  Advances in micro- and nanofabrication technologies enable us to achieve increasingly smaller mechanical transducers with micro- and nanosized moving parts, in which deformation and vibration are sensitively modified upon molecular adsorption. Nanomechanical biosensor are mechanical transducers with micron- or nanosized moving parts in which deformation and vibration at nanometer-scale are modified by tiny external and internal forces and added mass. In addition, since the size of the biomolecules are comparable to those of the dimensions of a mechanical system, mainly the thickness, the mechanical response is also highly sensitive to the mechanical properties of the adsorbed biomolecules, making this tool unique.  Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles. Our aim is to encourage scientists to publish their experimental and theoretical results in the field of nanomechanical biosensors and nanomechanical spectrometry.

We look forward to receiving your submissions.

Prof. Dr. Javier Tamayo
Dr. Priscila M. Kosaka
Guest Editors

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Keywords

  • biological sensors
  • instrumentation
  • transduction concepts
  • micro-/nanofabrication

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Published Papers (1 paper)

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Review

19 pages, 3853 KiB  
Review
Nano and Microsensors for Mammalian Cell Studies
by Ioana Voiculescu, Masaya Toda, Naoki Inomata, Takahito Ono and Fang Li
Micromachines 2018, 9(9), 439; https://doi.org/10.3390/mi9090439 - 31 Aug 2018
Cited by 11 | Viewed by 5668
Abstract
This review presents several sensors with dimensions at the nano- and micro-scale used for biological applications. Two types of cantilever beams employed as highly sensitive temperature sensors with biological applications will be presented. One type of cantilever beam is fabricated from composite materials [...] Read more.
This review presents several sensors with dimensions at the nano- and micro-scale used for biological applications. Two types of cantilever beams employed as highly sensitive temperature sensors with biological applications will be presented. One type of cantilever beam is fabricated from composite materials and is operated in the deflection mode. In order to achieve the high sensitivity required for detection of heat generated by a single mammalian cell, the cantilever beam temperature sensor presented in this review was microprocessed with a length at the microscale and a thickness in the nanoscale dimension. The second type of cantilever beam presented in this review was operated in the resonant frequency regime. The working principle of the vibrating cantilever beam temperature sensor is based on shifts in resonant frequency in response to temperature variations generated by mammalian cells. Besides the cantilever beam biosensors, two biosensors based on the electric cell-substrate impedance sensing (ECIS) used to monitor mammalian cells attachment and viability will be presented in this review. These ECIS sensors have dimensions at the microscale, with the gold films used for electrodes having thickness at the nanoscale. These micro/nano biosensors and their mammalian cell applications presented in the review demonstrates the diversity of the biosensor technology and applications. Full article
(This article belongs to the Special Issue Nanomechanical Biosensors)
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