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Micromachines
Special Issues
Recent Advances in Acoustofluidics
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Recent Advances in Acoustofluidics

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 8167

Special Issue Editor

Dr. David J. Collins

E-Mail Website
Guest Editor
Biomedical Engineering Department, University of Melbourne, Melbourne 3010, Australia
Interests: acoustofluidics; lab-on-a-chip; bioprinting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acoustic fields are finding increasing use in fluidic systems, including microfluidic ones, where their advantages of biocompatibility, rapid actuation, and wavelengths down to the scale of cells make this a very flexible approach. Acoustofluidic interactions include the generation of particle manipulation, fluid flow, and even modification of cellular activity. Acoustofluidic principles have thus been flexibly applied to a wide range of applications as varied as cell sorting, wastewater treatment, and additive manufacturing. A range of different actuation modalities can further be utilized, including resonant cavities and surface acoustic waves (SAW). This is a highly exciting and evolving discipline, where recent work has demonstrated new concepts and approaches (e.g., acoustic holography, phononics, nanoacoustics, hydrogel patterning, waveguides) that continue to enhance the flexibility and range of acoustofluidic applications. This Special Issue accordingly seeks to showcase research papers, short communications, and review articles that focus on acoustofluidic principles and applications, whether in the context of microfluidic devices or otherwise.

We look forward to receiving your submissions on Recent Advances in Acoustofluidics.

Dr. David J. Collins
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acoustofluidics
  • acoustic hologram
  • phononic crystal
  • diffraction
  • acoustic streaming
  • superstrate
  • waveguide
  • surface acoustic wave
  • patterning
  • sorting
  • microfluidics
  • waveguide
  • piezoelectric

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Published Papers (3 papers)

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Research

12 pages, 3973 KiB  
Article
A Bi-Directional Acoustic Micropump Driven by Oscillating Sharp-Edge Structures
by Bendong Liu, Meimei Qiao, Shaohua Zhang and Jiahui Yang
Micromachines 2023, 14(4), 860; https://doi.org/10.3390/mi14040860 - 15 Apr 2023
Cited by 3 | Viewed by 1976
Abstract
This paper proposes a bi-directional acoustic micropump driven by two groups of oscillating sharp-edge structures: one group of sharp-edge structures with inclined angles of 60° and a width of 40 μm, and another group with inclined angles of 45° and a width of [...] Read more.
This paper proposes a bi-directional acoustic micropump driven by two groups of oscillating sharp-edge structures: one group of sharp-edge structures with inclined angles of 60° and a width of 40 μm, and another group with inclined angles of 45° and a width of 25 μm. One of the groups of sharp-edge structures will vibrate under the excitation of the acoustic wave generated with a piezoelectric transducer at its corresponding resonant frequency. When one group of sharp-edge structures vibrates, the microfluid flows from left to right. When the other group of sharp-edge structures vibrates, the microfluid flows in the opposite direction. Some gaps are designed between the sharp-edge structures and the upper surface and the bottom surface of the microchannels, which can reduce the damping between the sharp-edge structures and the microchannels. Actuated with an acoustic wave of a different frequency, the microfluid in the microchannel can be driven bidirectionally by the inclined sharp-edge structures. The experiments show that the acoustic micropump, driven by oscillating sharp-edge structures, can produce a stable flow rate of up to 125 μm/s from left to right, when the transducer was activated at 20.0 kHz. When the transducer was activated at 12.8 kHz, the acoustic micropump can produce a stable flow rate of up to 85 μm/s from right to left. This bi-directional acoustic micropump, driven by oscillating sharp-edge structures, is easy to operate and shows great potential in various applications. Full article
(This article belongs to the Special Issue Recent Advances in Acoustofluidics)
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16 pages, 2173 KiB  
Article
Constant-Power versus Constant-Voltage Actuation in Frequency Sweeps for Acoustofluidic Applications
by Fabian Lickert, Henrik Bruus and Massimiliano Rossi
Micromachines 2022, 13(11), 1886; https://doi.org/10.3390/mi13111886 - 1 Nov 2022
Cited by 1 | Viewed by 1682
Abstract
Supplying a piezoelectric transducer with constant voltage or constant power during a frequency sweep can lead to different results in the determination of the acoustofluidic resonance frequencies, which are observed when studying the acoustophoretic displacements and velocities of particles suspended in a liquid-filled [...] Read more.
Supplying a piezoelectric transducer with constant voltage or constant power during a frequency sweep can lead to different results in the determination of the acoustofluidic resonance frequencies, which are observed when studying the acoustophoretic displacements and velocities of particles suspended in a liquid-filled microchannel. In this work, three cases are considered: (1) Constant input voltage into the power amplifier, (2) constant voltage across the piezoelectric transducer, and (3) constant average power dissipation in the transducer. For each case, the measured and the simulated responses are compared, and good agreement is obtained. It is shown that Case 1, the simplest and most frequently used approach, is largely affected by the impedance of the used amplifier and wiring, so it is therefore not suitable for a reproducible characterization of the intrinsic properties of the acoustofluidic device. Case 2 strongly favors resonances at frequencies yielding the lowest impedance of the piezoelectric transducer, so small details in the acoustic response at frequencies far from the transducer resonance can easily be missed. Case 3 provides the most reliable approach, revealing both the resonant frequency, where the power-efficiency is the highest, as well as other secondary resonances across the spectrum. Full article
(This article belongs to the Special Issue Recent Advances in Acoustofluidics)
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13 pages, 2696 KiB  
Article
Acoustic Manipulation of Intraocular Particles
by Ari Leshno, Avraham Kenigsberg, Heli Peleg-Levy, Silvia Piperno, Alon Skaat and Hagay Shpaisman
Micromachines 2022, 13(8), 1362; https://doi.org/10.3390/mi13081362 - 21 Aug 2022
Cited by 3 | Viewed by 2992
Abstract
Various conditions cause dispersions of particulate matter to circulate inside the anterior chamber of a human eye. These dispersed particles might reduce visual acuity or promote elevation of intraocular pressure (IOP), causing secondary complications such as particle related glaucoma, which is a major [...] Read more.
Various conditions cause dispersions of particulate matter to circulate inside the anterior chamber of a human eye. These dispersed particles might reduce visual acuity or promote elevation of intraocular pressure (IOP), causing secondary complications such as particle related glaucoma, which is a major cause of blindness. Medical and surgical treatment options are available to manage these complications, yet preventive measures are not currently available. Conceptually, manipulating these dispersed particles in a way that reduces their negative impact could prevent these complications. However, as the eye is a closed system, manipulating dispersed particles in it is challenging. Standing acoustic waves have been previously shown to be a versatile tool for manipulation of bioparticles from nano-sized extracellular vesicles up to millimeter-sized organisms. Here we introduce for the first time a novel method utilizing standing acoustic waves to noninvasively manipulate intraocular particles inside the anterior chamber. Using a cylindrical acoustic resonator, we show ex vivo manipulation of pigmentary particles inside porcine eyes. We study the effect of wave intensity over time and rule out temperature changes that could damage tissues. Optical coherence tomography and histologic evaluations show no signs of damage or any other side effect that could be attributed to acoustic manipulation. Finally, we lay out a clear pathway to how this technique can be used as a non-invasive tool for preventing secondary glaucoma. This concept has the potential to control and arrange intraocular particles in specific locations without causing any damage to ocular tissue and allow aqueous humor normal outflow which is crucial for maintaining proper IOP levels. Full article
(This article belongs to the Special Issue Recent Advances in Acoustofluidics)
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