Optofluidic Devices and Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "A:Physics".

Deadline for manuscript submissions: closed (1 December 2019) | Viewed by 36906

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Special Issue Editors


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Guest Editor
Departamento de Física, Universidad de La Laguna, Santa Cruz de Tenerife, Spain
Interests: optical sensors; optofluidics; microresonators; biosensing; fluorescence; rare-earth ions; glasses; semiconducting polymers

Special Issue Information

Dear Colleagues,

Optofluidic devices are of high scientific and industrial interest in chemistry, biology, material science, pharmacy, and medicine. In recent years, they have experienced strong development because of impressive achievements in the synergistic combination of photonics and micro/nanofluidics. Sensing and/or lasing platforms showing unprecedented sensitivities in extremely small analyte volumes, and allowing real time analysis within a lab-on-a-chip approach, have been developed. They are based on the interaction of fluids with evanescent waves induced at the surface of metallic or photonic structures, on the implementation of microcavities to induce optical resonances in the fluid medium or on other interactions of the microfluidic systems with light. In this context, a large variety of optofluidic devices has emerged, covering topics such as cell manipulation, microfabrication, water purification, energy production, catalytic reactions, microparticle sorting, micro-imaging, or bio-sensing. Moreover, the integration of these optofluidic devices in larger electro-optic platforms represents a highly valuable improvement towards advanced applications, such as those based on surface plasmon resonances that are already on the market.

In this Special Issue, we invite the scientific community working in this rapidly evolving field to publish recent research and/or review papers on these optofluidic devices and their applications.

Prof. Francisco Yubero
Prof. Fernando Lahoz
Guest Editors

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Keywords

  • Microfluidics
  • Nanofluidics
  • Optofluidic optical fibers
  • Lab-on-a-chip
  • Optical bio-sensing
  • Optical manipulation
  • Surface plasmon resonance
  • Evanescent wave physics

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Related Special Issue

Published Papers (11 papers)

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Editorial

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2 pages, 161 KiB  
Editorial
Editorial for the Special Issue on Optofluidic Devices and Applications
by Francisco Yubero and Fernando Lahoz
Micromachines 2020, 11(10), 884; https://doi.org/10.3390/mi11100884 - 23 Sep 2020
Viewed by 1543
Abstract
Optofluidic devices are of high scientific and industrial interest in chemistry, biology, material science, pharmacy, and medicine [...] Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)

Research

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14 pages, 16746 KiB  
Article
Silver Nanoprism Enhanced Colorimetry for Precise Detection of Dissolved Oxygen
by Yunfeng Zuo, Longfei Chen, Xuejia Hu, Fang Wang and Yi Yang
Micromachines 2020, 11(4), 383; https://doi.org/10.3390/mi11040383 - 4 Apr 2020
Cited by 9 | Viewed by 3436
Abstract
Dissolved oxygen (DO) content is an essential indicator for evaluating the quality of the water body and the main parameter for water quality monitoring. The development of high-precision DO detection methods is of great significance. This paper reports an integrated optofluidic device for [...] Read more.
Dissolved oxygen (DO) content is an essential indicator for evaluating the quality of the water body and the main parameter for water quality monitoring. The development of high-precision DO detection methods is of great significance. This paper reports an integrated optofluidic device for the high precision measurement of dissolved oxygen based on the characteristics of silver nanoprisms. Metal nanoparticles, especially silver nanoprisms, are extremely sensitive to their surroundings. In glucose and glucose oxidase systems, dissolved oxygen will be transformed into H2O2, which affects the oxidation and erosion process of nanoprisms, then influences the optical properties of nanoparticles. By detecting the shift in the plasma resonance peak of the silver nanoparticles, the dissolved oxygen (DO) content can be determined accurately. Great reconfigurability is one of the most significant advantages of the optofluidic device. By simply adjusting the flow rate ratio between the silver nanoprisms flow and the water sample flow, real-time continuous adjustment of the detection ranges of DO from 0 to 16 mg/L can be realized dynamically. The detection limit of this device is as low as 0.11 µM (3.52 µg/L) for DO measurement. Thus, the present optofluidic system has a wide range of potential applications in fields of biomedical analyses and water sensing. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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10 pages, 1667 KiB  
Article
Structural Stability of Optofluidic Nanostructures in Flow-Through Operation
by Yazan Bdour, Juan Gomez-Cruz and Carlos Escobedo
Micromachines 2020, 11(4), 373; https://doi.org/10.3390/mi11040373 - 2 Apr 2020
Cited by 3 | Viewed by 2915
Abstract
Optofluidic sensors based on periodic arrays of subwavelength apertures that support surface plasmon resonance can be employed as both optical sensors and nanofluidic structures. In flow-through operation, the nanoapertures experience pressure differences across the substrate in which they are fabricated, which imposes the [...] Read more.
Optofluidic sensors based on periodic arrays of subwavelength apertures that support surface plasmon resonance can be employed as both optical sensors and nanofluidic structures. In flow-through operation, the nanoapertures experience pressure differences across the substrate in which they are fabricated, which imposes the risk for structural failure. This work presents an investigation of the deflection and structural stability of nanohole array-based optofluidic sensors operating in flow-through mode. The analysis was approached using experiments, simulations via finite element method, and established theoretical models. The results depict that certain areas of the sensor deflect under pressure, with some regions suffering high mechanical stress. The offset in the deflection values between theoretical models and actual experimental values is overturned when only the effective area of the substrate, of 450 µm, is considered. Experimental, theoretical, and simulation results suggest that the periodic nanostructures can safely operate under trans-membrane pressures of up to 20 psi, which induce deflections of up to ~20 μm. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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16 pages, 3768 KiB  
Article
3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer
by Erik S. Hamilton, Vahid Ganjalizadeh, Joel G. Wright, Holger Schmidt and Aaron R. Hawkins
Micromachines 2020, 11(4), 349; https://doi.org/10.3390/mi11040349 - 27 Mar 2020
Cited by 13 | Viewed by 4267
Abstract
Optofluidic devices are capable of detecting single molecules, but greater sensitivity and specificity is desired through hydrodynamic focusing (HDF). Three-dimensional (3D) hydrodynamic focusing was implemented in 10-μm scale microchannel cross-sections made with a single sacrificial layer. HDF is achieved using buffer fluid to [...] Read more.
Optofluidic devices are capable of detecting single molecules, but greater sensitivity and specificity is desired through hydrodynamic focusing (HDF). Three-dimensional (3D) hydrodynamic focusing was implemented in 10-μm scale microchannel cross-sections made with a single sacrificial layer. HDF is achieved using buffer fluid to sheath the sample fluid, requiring four fluid ports to operate by pressure driven flow. A low-pressure chamber, or pit, formed by etching into a substrate, enables volumetric flow ratio-induced focusing at a low flow velocity. The single layer design simplifies surface micromachining and improves device yield by 1.56 times over previous work. The focusing design was integrated with optical waveguides and used in order to analyze fluorescent signals from beads in fluid flow. The implementation of the focusing scheme was found to narrow the distribution of bead velocity and fluorescent signal, giving rise to 33% more consistent signal. Reservoir effects were observed at low operational vacuum pressures and a balance between optofluidic signal variance and intensity was achieved. The implementation of the design in optofluidic sensors will enable higher detection sensitivity and sample specificity. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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7 pages, 3134 KiB  
Communication
Paper-based Photocatalysts Immobilization without Coffee Ring Effect for Photocatalytic Water Purification
by Qingwei Li, Huichao Lin, Xiaowen Huang, Maocui Lyu, Hongxia Zhang, Xiaoning Zhang and Ruiming Wang
Micromachines 2020, 11(3), 244; https://doi.org/10.3390/mi11030244 - 26 Feb 2020
Cited by 16 | Viewed by 2959
Abstract
Photocatalytic water purification is important for the degradation of organic pollutants, attracting intensive interests. Photocatalysts are preferred to be immobilized on a substrate in order to reduce the laborious separation and recycling steps. To get uniform irradiation, the photocatalysts are preferred to be [...] Read more.
Photocatalytic water purification is important for the degradation of organic pollutants, attracting intensive interests. Photocatalysts are preferred to be immobilized on a substrate in order to reduce the laborious separation and recycling steps. To get uniform irradiation, the photocatalysts are preferred to be even/uniform on the substrate without aggregation. Generally, the “coffee ring effect” occurs on the substrate during solvent evaporation, unfortunately resulting in the aggregation of the photocatalysts. This aggregation inevitably blocks the exposure of active sites, reactant exchange, and light absorption. Here, we reported a paper-based photocatalyst immobilization method to solve the “coffee ring” problem. We also used a “drop reactor” to achieve good photocatalytic efficiency with the advantages of large surface area, short diffusion lengths, simple operation, and uniform light absorption. Compared with the coffee ring type, the paper-based method showed higher water purification efficiency, indicating its potential application value in the future. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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14 pages, 6880 KiB  
Article
Dye-Doped ZnO Microcapsules for High Throughput and Sensitive Optofluidic Micro-Thermometry
by Najla Ghifari, Sara Rassouk, Zain Hayat, Abdelhafed Taleb, Adil Chahboun and Abdel I. El Abed
Micromachines 2020, 11(1), 100; https://doi.org/10.3390/mi11010100 - 17 Jan 2020
Cited by 8 | Viewed by 3461
Abstract
The main objective of this work is to show the proof of concept of a new optofluidic method for high throughput fluorescence-based thermometry, which enables the measure of temperature inside optofluidic microsystems at the millisecond (ms) time scale (high throughput). We used droplet [...] Read more.
The main objective of this work is to show the proof of concept of a new optofluidic method for high throughput fluorescence-based thermometry, which enables the measure of temperature inside optofluidic microsystems at the millisecond (ms) time scale (high throughput). We used droplet microfluidics to produce highly monodisperse microspheres from dispersed zinc oxide (ZnO) nanocrystals and doped them with rhodamine B (RhB) or/and rhodamine 6G (Rh6G). The fluorescence intensities of these two dyes are known to depend linearly on temperature but in two opposite manner. Their mixture enables for the construction of reference probe whose fluorescence does not depend practically on temperature. The use of zinc oxide microparticles as temperature probes in microfluidic channels has two main advantages: (i) avoid the diffusion and the adsorption of the dyes inside the walls of the microfluidic channels and (ii) enhance dissipation of the heat generated by the focused incident laser beam thanks to the high thermal conductivity of this material. Our results show that the fluorescence intensity of RhB decreases linearly with increasing temperature at a rate of about −2.2%/°C, in a very good agreement with the literature. In contrast, we observed for the first time a nonlinear change of the fluorescence intensity of Rh6G in ZnO microparticles with a minimum intensity at a temperature equal to 40 °C. This behaviour is reproducible and was observed only with ZnO microparticles doped with Rh6G. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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11 pages, 2847 KiB  
Article
Synthesis and a Photo-Stability Study of Organic Dyes for Electro-Fluidic Display
by Yong Deng, Shi Li, Dechao Ye, Hongwei Jiang, Biao Tang and Guofu Zhou
Micromachines 2020, 11(1), 81; https://doi.org/10.3390/mi11010081 - 11 Jan 2020
Cited by 12 | Viewed by 2870
Abstract
Electro-fluidic display (EFD) is one of the most promising reflective displays because of its full color and video speed. Colored EFD oil, which normally consists of soluble organic dyes and non-polar solvent, plays a critical role in color, electro-optical behavior, and the reliability [...] Read more.
Electro-fluidic display (EFD) is one of the most promising reflective displays because of its full color and video speed. Colored EFD oil, which normally consists of soluble organic dyes and non-polar solvent, plays a critical role in color, electro-optical behavior, and the reliability of the EFD devices. In this paper, we report our research on two kinds of electro-fluidic dyes based on anthraquinone and azo pyrazolone, including their synthesis, structure characterization, and application properties. Changes of absorbance curves, color coordinates of oils, and photoelectric responses of devices were studied in detail under accelerated irradiation to investigate the photo-stability and reliability properties of synthesized oil materials and devices. Photoelectric responses and photo stability of dyes are highly varied depending on their structures. We found that 1,4-dlialkylamino anthraqinone and mono azo pyrazolone dyes are much more stable than 1,8-dlialkylamino anthraqinone and corresponding bisazo pyrazolone dyes. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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12 pages, 4268 KiB  
Article
Aperture Ratio Improvement by Optimizing the Voltage Slope and Reverse Pulse in the Driving Waveform for Electrowetting Displays
by Zichuan Yi, Wenyong Feng, Li Wang, Liming Liu, Yue Lin, Wenyao He, Lingling Shui, Chongfu Zhang, Zhi Zhang and Guofu Zhou
Micromachines 2019, 10(12), 862; https://doi.org/10.3390/mi10120862 - 7 Dec 2019
Cited by 27 | Viewed by 3305
Abstract
Electrowetting display (EWD) performance is severely affected by ink distribution and charge trapping in pixel cells. Therefore, a multi structural driving waveform is proposed for improving the aperture ratio of EWDs. In this paper, the hysteresis characteristic (capacitance–voltage, C-V) curve of the EWD [...] Read more.
Electrowetting display (EWD) performance is severely affected by ink distribution and charge trapping in pixel cells. Therefore, a multi structural driving waveform is proposed for improving the aperture ratio of EWDs. In this paper, the hysteresis characteristic (capacitance–voltage, C-V) curve of the EWD pixel is tested and analyzed for obtaining the driving voltage value at the inflection point of the driving waveform. In the composition of driving waveform, a voltage slope is designed for preventing ink dispersion and a reverse pulse is designed for releasing the trapped charge which is caused by hysteresis characteristic. Finally, the frequency and the duty cycle of the driving waveform are optimized for the max aperture ratio by a series of testing. The experimental results show that the proposed driving waveform can improve the ink dispersion behavior, and the aperture ratio of the EWD is about 8% higher than the conventional driving waveform. At the same time, the response speed of the driving waveform can satisfy the dynamic display in EWDs, which provides a new idea for the design of the EWD driving scheme. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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11 pages, 3065 KiB  
Article
Different Regimes of Opto-fluidics for Biological Manipulation
by John T. Winskas, Hao Wang, Arsenii Zhdanov, Surya Cheemalapati, Andrew Deonarine, Sandy Westerheide and Anna Pyayt
Micromachines 2019, 10(12), 802; https://doi.org/10.3390/mi10120802 - 21 Nov 2019
Cited by 7 | Viewed by 3107
Abstract
Metallic structures can be used for the localized heating of fluid and the controlled generation of microfluidic currents. Carefully designed currents can move and trap small particles and cells. Here we demonstrate a new bi-metallic substrate that allows much more powerful micro-scale manipulation. [...] Read more.
Metallic structures can be used for the localized heating of fluid and the controlled generation of microfluidic currents. Carefully designed currents can move and trap small particles and cells. Here we demonstrate a new bi-metallic substrate that allows much more powerful micro-scale manipulation. We show that there are multiple regimes of opto-fluidic manipulation that can be controlled by an external laser power. While the lowest power does not affect even small objects, medium power can be used for efficiently capturing and trapping particles and cells. Finally, the high-power regime can be used for 3D levitation that, for the first time, has been demonstrated in this paper. Additionally, we demonstrate opto-fluidic manipulation for an extraordinarily dynamic range of masses extending eight orders of magnitude: from 80 fg nano-wires to 5.4 µg live worms. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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Review

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20 pages, 5637 KiB  
Review
A Review on Optoelectrokinetics-Based Manipulation and Fabrication of Micro/Nanomaterials
by Wenfeng Liang, Lianqing Liu, Junhai Wang, Xieliu Yang, Yuechao Wang, Wen Jung Li and Wenguang Yang
Micromachines 2020, 11(1), 78; https://doi.org/10.3390/mi11010078 - 10 Jan 2020
Cited by 11 | Viewed by 4071
Abstract
Optoelectrokinetics (OEK), a fusion of optics, electrokinetics, and microfluidics, has been demonstrated to offer a series of extraordinary advantages in the manipulation and fabrication of micro/nanomaterials, such as requiring no mask, programmability, flexibility, and rapidness. In this paper, we summarize a variety of [...] Read more.
Optoelectrokinetics (OEK), a fusion of optics, electrokinetics, and microfluidics, has been demonstrated to offer a series of extraordinary advantages in the manipulation and fabrication of micro/nanomaterials, such as requiring no mask, programmability, flexibility, and rapidness. In this paper, we summarize a variety of differently structured OEK chips, followed by a discussion on how they are fabricated and the ways in which they work. We also review how three differently sized polystyrene beads can be separated simultaneously, how a variety of nanoparticles can be assembled, and how micro/nanomaterials can be fabricated into functional devices. Another focus of our paper is on mask-free fabrication and assembly of hydrogel-based micro/nanostructures and its possible applications in biological fields. We provide a summary of the current challenges facing the OEK technique and its future prospects at the end of this paper. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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17 pages, 34507 KiB  
Review
Autonomous and In Situ Ocean Environmental Monitoring on Optofluidic Platform
by Fang Wang, Jiaomeng Zhu, Longfei Chen, Yunfeng Zuo, Xuejia Hu and Yi Yang
Micromachines 2020, 11(1), 69; https://doi.org/10.3390/mi11010069 - 8 Jan 2020
Cited by 18 | Viewed by 4208
Abstract
Determining the distributions and variations of chemical elements in oceans has significant meanings for understanding the biogeochemical cycles, evaluating seawater pollution, and forecasting the occurrence of marine disasters. The primary chemical parameters of ocean monitoring include nutrients, pH, dissolved oxygen (DO), and heavy [...] Read more.
Determining the distributions and variations of chemical elements in oceans has significant meanings for understanding the biogeochemical cycles, evaluating seawater pollution, and forecasting the occurrence of marine disasters. The primary chemical parameters of ocean monitoring include nutrients, pH, dissolved oxygen (DO), and heavy metals. At present, ocean monitoring mainly relies on laboratory analysis, which is hindered in applications due to its large size, high power consumption, and low representative and time-sensitive detection results. By integrating photonics and microfluidics into one chip, optofluidics brings new opportunities to develop portable microsystems for ocean monitoring. Optofluidic platforms have advantages in respect of size, cost, timeliness, and parallel processing of samples compared with traditional instruments. This review describes the applications of optofluidic platforms on autonomous and in situ ocean environmental monitoring, with an emphasis on their principles, sensing properties, advantages, and disadvantages. Predictably, autonomous and in situ systems based on optofluidic platforms will have important applications in ocean environmental monitoring. Full article
(This article belongs to the Special Issue Optofluidic Devices and Applications)
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