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Targeted Functional Probe: Current Research Trends and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3186

Special Issue Editors


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Guest Editor
School of Life Sciences, Central China Normal University, Wuhan 430079, China
Interests: targeted functional probe; luminescent materials; tumor theranostics; peptide chemistry; analyte-responsive imaging; targeted therapy

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Guest Editor
College of Physical Science and Technology, Central China Normal University, Wuhan 430079, China
Interests: computer-aided drug design; biomolecular interactions; molecular dynamics simulation; biophysics; bioinformatics

Special Issue Information

Dear Colleagues,

Targeted functional probes have been deemed as essential for accurate diagnostic imaging. These probes can be conjugated with different types of ligands, for example organic molecules, peptides, and proteins, to target specific biological sites. During the last few decades, many targeted probes based on small molecules, polymers, and nanomaterials have been synthesized to detect different types of analytes with outstanding performance.

The development of targeted functional probes is promising for the study of diseases. They can selectively visualize tumor cells and invisible organelles. With the use of different real-time imaging techniques, such as fluorescence imaging (FI), magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), scientists can directly measure the signals provided by the probe to explore the location and function of different targets, and even monitor the changes in the condition and disorder of the target.

The purpose of this Special Issue is to collect the latest advances in the design and development of targeted functional probes. We welcome all original research works, including research articles, communications, and reviews on new targeting strategies or sensing mechanisms, the design of multi-functional targeted probes, and the widespread application of targeted functional probes.

Dr. Lijun Jiang
Dr. Yunhui Peng
Guest Editors

Manuscript Submission Information

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Keywords

  • new design strategies
  • new sensing mechanisms
  • computer-aided design
  • selective targeting among multiple analytes
  • multi-functionality
  • targeted imaging/therapy against cancer

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Published Papers (1 paper)

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Review

23 pages, 6315 KiB  
Review
Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy
by Shaozhen Jing, Xiaolei Wu, Dou Niu, Jing Wang, Chung-Hang Leung and Wanhe Wang
Molecules 2024, 29(1), 256; https://doi.org/10.3390/molecules29010256 - 3 Jan 2024
Cited by 6 | Viewed by 2697
Abstract
Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop [...] Read more.
Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop novel near-infrared (NIR) iridium(III) complexes to improve signal-to-noise ratio and enhance tissue penetration. In this review, we summarize different classes of organometallic NIR iridium(III) complexes for detection and therapy, including cyclometalated ligand-enabled NIR iridium(III) complexes and NIR-dye-conjugated iridium(III) complexes. Moreover, the prospects and challenges for organometallic NIR iridium(III) complexes for targeted detection and therapy are discussed. Full article
(This article belongs to the Special Issue Targeted Functional Probe: Current Research Trends and Applications)
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