Recent Progress in the Preparation of Novel Heterocyclic Compounds and Their Therapeutic Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 2798
Special Issue Editors
Interests: green synthesis; heterocyclic scaffolds; medicinal chemistry; sustainable synthesis; heterogeneous catalysts
Special Issues, Collections and Topics in MDPI journals
Interests: heterocyclic moieties; biological activity; organic synthesis; cascade reactions; microwaves; sonochemistry; grinding chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocyclic compounds with pyrazole, pyridine, pyrimidine, pyrans, triazole, indole and isoxazole scaffolds offer distinct pharmacological benefits. These heterocyclic compounds control auto-immune disorders with their anti-rheumatoid, anti-inflammatory, antioxidant, anti-diabetic and anti-sclerotic activities. They also contribute to treatments of cancer, helminthic and other microbial diseases. Further, some fused heterocyclic rings append their microbial inhibitory properties and are also known to relax and calm the central nervous system by acting as depressants.
One pot synthesis of heterocyclic compounds is an efficient approach to avoid the separation of the reaction intermediates. This method conserves resources, offering better yields in a shorter time in a green environment. The one-pot synthesis in water, and eco-friendly solvents with the highest specific heat capacity, allow better reaction conditions. To further assure clean reactions, solvent-free systems have been explored using non-conventional techniques such as grinding, ultra-sonication and microwave irradiation. Grindstone reactions have received significant attention owing to their high yields with less expensive tools such as mortar and a pestle. These reactions offer cheaper and economic reaction conditions, contributing to authorizable reaction mechanisms. The chemistry and biology of nitrogen and oxygen-containing heterocyclic compounds will be the key theme of this issue, comprising both original research and review articles. It will focus on novel developments in the synthesis and reactivity of new heterocyclic moieties and their promising biological activities.
Prof. Dr. Sreekantha B. Jonnalagadda
Dr. Suresh Maddila
Guest Editors
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Keywords
- green synthesis
- one-pot reactions
- N-heterocycles
- O-heterocycles
- MCRs
- biological applications
- heterogeneous catalysis
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