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New Insights into Antimicrobial Drug Discovery

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 3777

Special Issue Editors


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Guest Editor
Centro de Investigação em Química da Universidade do Porto (CIQUP), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169–007 Porto, Portugal
Interests: drug discovery; nanomedicine; ADME-Tox; neurodegenerative; infectious diseases; antioxidants
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Guest Editor
Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal
Interests: medicinal chemistry; drug discovery; new chemical entities; analytical methods; in vitro screening assays
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
Interests: medicinal chemistry; organic chemistry; neurodegenerative diseases; infectious diseases

Special Issue Information

Dear Colleagues,

It is undeniable that antimicrobial resistance (AMR) is an emergent health problem so dire that it can potentially lead to a ‘post-antibiotic’ era, marked by the end of effective antibiotics. The World Health Organization (WHO) has already defined AMR as a serious threat to global public health, with estimates that AMR is responsible for over 700,000 deaths annually around the world. Despite the increased awareness, the clinical antibacterial pipeline remains insufficient, and there is a pressing and unmet need for innovative antimicrobial drugs.

New chemical entities to tackle AMR are limited, and exploring new scaffolds to achieve new and better outcomes is urgently needed. This proposed Special Issue will provide a platform for researchers to publish their recent findings and perspectives in the design, synthesis, and identification of new antimicrobial agents. High-quality reviews in the field will also be accepted.

Prof. Dr. Fernanda Borges
Dr. Alexandra Gaspar
Dr. Fernando Cagide Fagin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobials
  • antimicrobial resistance
  • drug discovery
  • antimicrobial mechanism of action
  • innovative scaffolds
  • cinnamic acids and derivatives
  • benzoic acids and derivatives
  • chromones and analogues
  • coumarins and analogues
  • quinones and analogues
  • quinolones and analogues
  • oxazolidinones and analogues
  • ionic liquids and analogues
  • nanosystems/nanomaterials
  • peptides/glycopeptides
  • phytochemicals
  • miscellaneous

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Published Papers (1 paper)

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Research

10 pages, 1220 KiB  
Article
Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
by Melissa M. Cadelis, Soeren Geese, Benedict B. Uy, Daniel R. Mulholland, Shara J. van de Pas, Alex Grey, Bevan S. Weir, Brent R. Copp and Siouxsie Wiles
Molecules 2021, 26(4), 1094; https://doi.org/10.3390/molecules26041094 - 19 Feb 2021
Cited by 10 | Viewed by 3051
Abstract
Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (25). Structure elucidation was conducted by nuclear magnetic resonance [...] Read more.
Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (25). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Drug Discovery)
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