Synthesis of Heterocyclic Compounds via Cycloadditions: Applications in Medicinal Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 6666
Special Issue Editors
Interests: flow chemistry; organic synthesis; total synthesis; cycloadditions; heterocyclics; carbohydrates; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: synthetic methodology; computational chemistry and molecular modelling; pharmacophore design; medicinal Chemistry; ligand–protein interactions; peptide folding; docking
Special Issues, Collections and Topics in MDPI journals
Interests: organic synthesis; heterocycles; dipyridothiazines; structural analysis; lipophylicity; SAR
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocyclic compounds, also known as heterocycles, are the most common constituents of many pharmaceutical drugs. They are the major class of organic chemical compounds characterized by the notion that some or all of the atoms are joined in rings containing at least one atom other than carbon. Heterocyclic compounds are used in agrochemicals and pharmaceutical industries. They are used as starting materials in the synthesis of organic compounds and used in corrosion inhibitors, sanitizers, antiordinates, developers, pesticides, dyes and plastics.
The hybridization of two heterocyclic scaffolds forms a single compound, with the potential to have antibacterial, antimalarial, antitubercular and anticancer activity. Active functional groups like hydroxyl, methyl, carbonyl, carboxyl, amino, phosphate, etc., are often used in the synthetic strategy to join the two scaffolds together. Further, heterocycles including beta-lactams, pyrimidinones, 1,3,4-thiadiazoles and their molecular hybrids with different pharmacophoric assemblies following the hetero Diels–Alder methodology are known for their biological activities under in vitro conditions. Understanding how the rings of this class of antibiotics are formed is crucial to developing new treatments to combat antibiotic resistance using cycloadditions.
Cycloaddition reactions are considered among the most powerful bond-forming reactions in organic synthesis because of their ability to form many bonds in one step and the potential to generate several stereogenic centers at the same time with predictable stereochemical outcomes. Cycloaddition reactions are applied to the synthesis of anticancer compounds by making use of classical Diels–Alder and their hetero version for the design and synthesis of compounds that were tested for their antiproliferative activities as well as apoptosis. 1,3-dipolar cycloaddition reactions of selected 1,3-dipoles, such as azides, nitrones, nitrile oxides, nitrile imines and azomethine ylides, also have a major application in the preparation of key intermediates for anticancer synthesis. In addition, the products obtained from the pericyclic reaction approaches are important for anticancer activities and the relevant biological data are highlighted.
Medicinal chemistry remains the most valuable science and plays the most critical role in the drug-development process. It acts as the backbone of the drug-discovery framework that provides a comprehensive understanding of the underlying principles of drug action and behavior within the body, which is fundamental to today's pharmaceutical care and patient counseling.
This Special Issue targets the public understanding of the chemistry behind heterocycles for pharmaceutical applications. Preference will be given to articles, which focus on target-based design strategies, organic synthesis, in vitro assays, enzymatic assays that confirm the target, in vivo experiments, SAR, and docking that improves the understanding of drug design and action. The targets are including but are not limited to: Kinases, DNA topoisomerases, Tubulin, and HDAC.
Dr. Lalitha Gummidi
Dr. Parvesh Singh
Prof. Dr. Beata Morak-Młodawska
Guest Editors
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Keywords
- heterocycles
- synthesis
- anticancer
- in vitro
- cycloadditions
- drug
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