MCRs and Related One-Pot Organic Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (15 July 2016) | Viewed by 50926
Special Issue Editor
Interests: synthetic methodology; multi component reactions; biocatalysis; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organic Synthesis is the science of making new, unexplored molecules. From simple building blocks to complex products. This is exactly what is at the heart of this Special Issue of “Molecules”.
Currently, Synthetic Organic chemists are able to design a multistep synthesis for almost any conceivable chemical structure by a rational approach based on the large toolbox of synthetic methods available and a retrosynthetic analysis. Traditionally, the reagents and conditions for each of the reaction steps need to be optimized to give a good yield and a pure product, with as little work as possible. To be useful in organic synthesis, methods must be reliable for a broad range of substrates. For complex organic molecules, however, executing such a “total” synthesis is still far from trivial, and is often neither simple nor elegant. The routes are often lengthy, with many reaction steps, employing a multitude of different, sometimes highly creative, protective group strategies, and/or using “metal-based”-catalysis. Truly sustainable production of complex, highly functionalized molecules for advanced application as (fine) chemicals and pharmaceuticals or in food, in materials, or in catalysis is still beyond any state of maturity. Thus, there is a clear need for the discovery and development of clean, atom- and step-efficient one-pot syntheses for the sustainable production of molecularly diverse and structurally complex organic molecules with high-added-values.
Mulicomponent reactions (MCRs) are increasingly appreciated as efficient synthesis tools to rapidly access complex products. With MCRs, molecules can be assembled from three or more starting materials in a one-pot process. MCRs involve the inherent formation of several bonds in a single operation, without isolating the intermediates, changing the reaction conditions, and often without adding further reagents. Therefore, MCRs address sustainability by atom-, step-, and, thus, eco-efficiency, reducing the number of intermediate steps and functional group manipulations and avoiding protective group strategies. Syntheses involving MCRs save time and energy (step efficiency) and proceed with high convergency (process efficiency). In addition, MCRs are ideally suited for combinatorial chemistry and library design, and are of great utility in medicinal chemistry, material science, recognition (host-guest) chemistry, and catalyst design. Notably, MCRs are believed to be crucial in exploiting the full potential of “diversity-oriented synthesis” (DOS) and “biology-oriented synthesis” (BIOS) design strategies for effective and functional library synthesis uncovering virgin areas of biologically relevant chemical space.
In this Special Issue of Molecules, research articles covering all areas of MCR-chemistry and related one-pot syntheses are welcomed to provide an interesting “snap-shot” of the current state-of-the-art in this exciting organic chemistry research field.
Prof. Romano V. A. Orru
Guest Editor
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Keywords
- organic synthesis
- multicomponent reaction
- diversity oriented synthesis
- atom- and step efficiency
- one-pot reactions
- cascade reactions
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