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Plant Associated Microbes as Source of New Pharmacophores and Bioactive...
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Plant Associated Microbes as Source of New Pharmacophores and Bioactive Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 13554

Special Issue Editors

Dr. Harinantenaina Liva Rakotondraibe

E-Mail Website
Guest Editor
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
Interests: natural products; structure elucidation; anticancer; antimalarial; antibacterial; vector control; new natural product sources; endophytes; lichens and mycobionts; soil and marine microbes
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shugeng Cao

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Hawaii at Hilo, Hilo, HI 96720-4091, USA
Interests: natural products; isolation and structure elucidation; anticancer; cancer prevention; antibacterial; antifungal; endophytic fungi; marine microorganisms; herbal medicine; small molecules and their biological functions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbes have been known to contribute to the discovery of many FDA approved drugs that help to fight against deadly diseases, including cancer, malaria, viral infections, and chemoresistance. Many natural product researchers explore unique source of microbes in order to discover new pharmacophore for probing new pharacological challenges. Plant-associated microbes are sources of many bioactive metabolites that can be synthetically developed or can used as chemical probe for many chemical and pharmacological studies. This Special Issue will focus on plant (higher plants and liverworts) associated microbes as source of new pharmacophore and bioactive compounds.

Dr. Harinantenaina Liva Rakotondraibe
Prof. Dr. Shugeng Cao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural Products
  • Microbes
  • Epiphytes
  • Endophytes
  • Bioactive
  • Secondary Metabolites
  • Plant-microbe Symbiosis

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Published Papers (3 papers)

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8 pages, 882 KiB  
Article
Biofilm Inhibitory Abscisic Acid Derivatives from the Plant-Associated Dothideomycete Fungus, Roussoella sp.
by Chayanard Phukhamsakda, Allan Patrick G. Macabeo, Kamila Tomoko Yuyama, Kevin David Hyde and Marc Stadler
Molecules 2018, 23(9), 2190; https://doi.org/10.3390/molecules23092190 - 30 Aug 2018
Cited by 24 | Viewed by 4701
Abstract
Roussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp. (MFLUCC 17-2059), which represents an undescribed species, was isolated from Clematis subumbellata Kurz, [...] Read more.
Roussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp. (MFLUCC 17-2059), which represents an undescribed species, was isolated from Clematis subumbellata Kurz, fermented in yeast-malt medium and explored for its secondary metabolite production. Bioassay-guided fractionation of the crude extract yielded the new abscisic acid derivative, roussoellenic acid (1), along with pestabacillin B (2), a related congener, and the cyclodipeptide, cyclo(S-Pro-S-Ile) (3). The structure of 1 was determined by 2D NMR spectroscopy and HR-ESIMS data analysis. Compounds 1 and 2 showed inhibitory activity on biofilm formation by Staphylococcus aureus. The biofilm formation of S. aureus was reduced to 34% at 16 µg/mL by roussoellenic acid (1), while pestabacillin B (2) only showed 36% inhibition at 256 µg/mL. In addition, compound 1 also had weak cytotoxic effects on L929 murine fibroblasts and human KB3-1 cancer cells. Full article
(This article belongs to the Special Issue Plant Associated Microbes as Source of New Pharmacophores and Bioactive Compounds)
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11 pages, 985 KiB  
Article
An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
by Chunshun Li, Ariel M. Sarotti, Xiaohua Wu, Baojun Yang, James Turkson, Yongfei Chen, Qingsong Liu and Shugeng Cao
Molecules 2019, 24(1), 196; https://doi.org/10.3390/molecules24010196 - 7 Jan 2019
Cited by 12 | Viewed by 4686
Abstract
A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus [...] Read more.
A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 μM. Full article
(This article belongs to the Special Issue Plant Associated Microbes as Source of New Pharmacophores and Bioactive Compounds)
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8 pages, 773 KiB  
Article
Ent-homocyclopiamine B, a Prenylated Indole Alkaloid of Biogenetic Interest from the Endophytic Fungus Penicillium concentricum
by Tehane Ali, Tiffany M. Pham, Kou-San Ju and Harinantenaina L. Rakotondraibe
Molecules 2019, 24(2), 218; https://doi.org/10.3390/molecules24020218 - 9 Jan 2019
Cited by 10 | Viewed by 3468
Abstract
Ent-homocyclopiamine B (1), a new prenylated indole alkaloid bearing an alicyclic nitro group along with 2-methylbutane-1,2,4-triol (2) were isolated from an endophytic fungus Penicillium concentricum of the liverwort Trichocolea tomentella (Trichocoleaceae). The structure of 1 was elucidated through [...] Read more.
Ent-homocyclopiamine B (1), a new prenylated indole alkaloid bearing an alicyclic nitro group along with 2-methylbutane-1,2,4-triol (2) were isolated from an endophytic fungus Penicillium concentricum of the liverwort Trichocolea tomentella (Trichocoleaceae). The structure of 1 was elucidated through extensive spectroscopic analyses and comparison with data reported for a structurally related nitro-bearing Penicillium metabolite, clopiamine C (3), which contain an indolizidine ring instead of the quinolizine ring in 1. The new compound, ent-homocyclopiamine B, exhibited slight growth inhibition against Gram-positive bacteria. Based on the reported biosynthesis of related compounds and the isolation of the mevalonic acid derived compound 2-methyl-1,2,4-butanetriol (2), we proposed that ent-homocylopiamine B (1) was biosynthesized from lysine and prenyl group-producing mevalonic pathway. Full article
(This article belongs to the Special Issue Plant Associated Microbes as Source of New Pharmacophores and Bioactive Compounds)
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