Current and Novel Therapeutic Molecules for Treatment of Neuroinflammation-Mediated Neurodegenerative Disorders
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2979
Special Issue Editor
Interests: inflammation; microglia; astrocytes; neurodegeneration; Parkinson's disease; neuroinflammation; immune system; brain; inflammatory bowel diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is a defense mechanism that initially can have beneficial effects for the central nervous system (CNS), by removing or inhibiting diverse pathogens or cellular debris and promoting tissue repair. Sustained inflammatory responses, however, are detrimental, and they inhibit regeneration. Interestingly, neuroinflammation is emerging as a common feature to target in most CNS pathologies. Neuroinflammation is associated with various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and others. The lack of effective treatments for most neurodegenerative diseases has prompted the search for novel therapeutic options.
Recent studies suggest the effectiveness of targeted delivery of small molecules to reduce neuroinflammation. A factor limiting the effectiveness of many pharmacological treatments is represented by the blood brain barrier which can lead to the suboptimal action of drugs in the CNS because the neurotherapeutic compounds are currently administered systemically without spatial or temporal control. Emerging technologies of new molecules, such as nanomaterials or small molecules, are providing promising tools to effectively access the brain in a targeted and controlled manner.
This special issue aims to collect current therapeutic options that have a significant impact in the treatment of inflammatory-based neurodegenerative diseases. A further goal is to review emerging therapies in clinical development, including agents that interfere with pathological processes deemed important for neurodegeneration or that aim to enhance reparative and neuroprotective responses. Finally, attention is paid to those studies aimed at identifying therapeutic drugs, small molecules and biological products that can modulate and control neuroinflammation.
Prof. Dr. Maria Antonietta Panaro
Guest Editor
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Keywords
- brain
- neuroinflammation
- neurodegeneration
- small-molecule therapeutics
- bioactive compounds
- natural products
- drug development
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