Sugar Substitutes and Obesity, Diabetes and Metabolic Syndrome
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 March 2018) | Viewed by 64906
Special Issue Editors
Interests: seaweeds; sulfated polysaccharides; fucoidans; carrageenan; laminarin; fucoxanthin; alginates; ulvans; polyphenols; carotenoids; obesity; type 2 diabetes; cardiovascular; metabolic disorders; hypertension
Special Issues, Collections and Topics in MDPI journals
Interests: Gastroenterology; Diabetes; Obesity; Metabolic Syndrome; Pharmacology; Toxicology; Clinical trials
Special Issue Information
Dear Collagues,
Diabetes is one of the major global public health problems and its prevalent is increasing at an alarming rate in all over the world. Diabetic patients are usually choosing sugar substitutes as a sweetening agent mainly due to their no or lower calorific values (0.0–3.0 kcal/g vs 4.0 kcal/g in sucrose) and more sweetening power compared to sucrose. Additionally, chronic or over consumption of refined sugar or sucrose may cause severe physiological and clinical problems, such as overweight, obesity, diabetes and many other diseases related to metabolic syndrome. Hence, sugar substitute or non-sugar sweeteners are getting more and more popularity among people with above-mentioned diseases. Several sugar substitutes are available in the market, such as fructose, saccharin, aspartame, sugar alcohols or combination of these which many of them have been found to have mild to severe side effects.
Some recent studies have demonstrated links between the consumption of artificial sweeteners and increased body weight, fasting blood glucose and decreased insulin sensitivity in neonatal mice and increased insulin resistance, advance glycation end products, non-alcoholic fatty liver diseases in normal individual and these factors are closely linked to the development type 2 diabetes. Although no significant effects of the consumption of artificial sweeteners have been observed in diabetics in case of acute or short-term study but the effects chronic consumption of most of the artificial sweeteners either in normal or diabetic individuals are still unknown. Up to the present, there are controversial issues among the scientists on various experimental investigations involving both humans and animals on the consumption of artificial sweeteners. In all over the world there is a paucity of scientific information on the use of artificial sweeteners in diabetic subjects considering the environmental and genetic factors as well.
We invite investigators to contribute original research and review articles focusing the effects of various sugar substitutes/sweeteners (including natural and artificial) particularly in diabetic condition to understand more about their beneficial and detrimental effects on health particularly in diabetic condition. Articles from both clinical and non-clinical (experimental, e.g., animal studies) studies will be considered for publications in this special issue.
Prof. Dr. Md. Shahidul Islam
Dr. Bettina Karin Wölnerhanssen
Guest Editor
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Keywords
- Artificial sweeteners
- Sugar substitute
- Diabetes
- Obesity
- Metabolic syndrome
- Aspartame
- Saccharin
- Sucralose
- Sugar alcohols
- Stevia
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