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Metal-Based Nanoparticles Synthesis and Antimicrobial Applications
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Metal-Based Nanoparticles Synthesis and Antimicrobial Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 11186

Special Issue Editor

Dr. Luca Scotti

E-Mail Website1 Website2
Guest Editor
Department of Medical, Oral and Biotechnological Sciences, University “G. d'Annunzio” of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy
Interests: green synthesis; metal nanoclusters; microbiological application; biochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The continued rise of antimicrobial resistance (AMR) in fungi and bacteria, which are not treatable with existing drugs, is a cause for global alarm. In recent years, there has been a fast spread of multi- and pan-drug-resistant bacteria (also known as “superbugs”) which are responsible for infections not treatable with existing antibiotics. Moreover, the rise of multi-drug resistance in fungi is also a cause for alarm. The consequences of this increasing antimicrobial resistance (AMR) could be devastating. According to estimates, by the year 2050, human deaths attributable to AMR could reach 10 million. In addition to this, the economic consequences due to the continuous increase in healthcare costs should be considered. Thus, there is an urgent need to develop new antimicrobial agents to overcome AMR. Metals nanoparticles (MNPs) have attracted the attention of many researchers for their antibacterial and antifungal properties, varying between 10 and 100 ppm. The plethora of MNP synthesis protocols can be grouped into physical, chemical, and biological green methods. However, to achieve successful nanoparticle-based therapies, some important issues still need to be solved. Syntheses are very different and often conducted in the presence of reducing agents, stabilizers, and contaminants that may interfere in terms of the effectiveness and toxicity of the nanoparticle formulations themselves. Structural characterizations are often incomplete so that, in many cases, comparison of results is not possible. This is probably due to the fact that metal nanoparticles are a new tool for use against antimicrobial resistance.

Dr. Luca Scotti
Guest Editor

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Keywords

  • metals
  • nanoclusters
  • organic synthesis
  • green synthesis

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Published Papers (5 papers)

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Research

13 pages, 2412 KiB  
Article
The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
by Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach and Gabriel-Alejandro Martínez-Castañón
Molecules 2024, 29(18), 4422; https://doi.org/10.3390/molecules29184422 - 18 Sep 2024
Cited by 1 | Viewed by 928
Abstract
This study evaluated push-out bond test (POBT), surface roughness, and antimicrobial properties against Enterococcus faecalis of bioceramic sealers supplemented with silver nanoparticles (AgNPs). The sealers tested were CeraSeal®, EndoSequence® BC SealerTM, and Bio-C® Sealer. The POBT was [...] Read more.
This study evaluated push-out bond test (POBT), surface roughness, and antimicrobial properties against Enterococcus faecalis of bioceramic sealers supplemented with silver nanoparticles (AgNPs). The sealers tested were CeraSeal®, EndoSequence® BC SealerTM, and Bio-C® Sealer. The POBT was measured with a Universal Testing Machine, and the type of failure was evaluated with a stereomicroscope. The roughness average (Sa) and peak–valley height (Sy) values were evaluated by atomic force microscopy. The bacterial growth inhibition was evaluated using a disk diffusion test, and antimicrobial activity was determined with the plate microdilution method. The POBT showed no significant difference between sealers with and those without NPs in cervical and apical thirds (p > 0.05). In the middle third, the adhesion force was significant for Endosequence BC Sealer® (p < 0.05). The results showed that the Sa and Sy parameters, when AgNPs were added, did not show a statistically significant difference compared to the groups without nanoparticles (p > 0.05). All tested sealers showed bacterial growth inhibition, but no significant difference was found. Their efficacy, in descending order of antibacterial activity when AgNPs were added, is as follows: EndoSequence® BC SealerTM > Bio-C® Sealer > CeraSeal®. The incorporation of AgNPs into bioceramics improves antimicrobial activity without affecting mechanical properties. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles Synthesis and Antimicrobial Applications)
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17 pages, 4914 KiB  
Article
Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using Dendrobium anosmum and Its Effect on Acne Vulgaris
by Yu Yang Tan, Ling Shing Wong, Kar Lin Nyam, Kitiyaporn Wittayanarakul, Nurliyana Ahmad Zawawi, Kavitha Rajendran, Sinovassane Djearamane and Anto Cordelia Tanislaus Antony Dhanapal
Molecules 2023, 28(19), 6749; https://doi.org/10.3390/molecules28196749 - 22 Sep 2023
Cited by 2 | Viewed by 3364
Abstract
Zinc oxide nanoparticles have high levels of biocompatibility, a low impact on environmental contamination, and suitable to be used as an ingredient for environmentally friendly skincare products. In this study, biogenically synthesized zinc oxide nanoparticles using Dendrobium anosum are used as a reducing [...] Read more.
Zinc oxide nanoparticles have high levels of biocompatibility, a low impact on environmental contamination, and suitable to be used as an ingredient for environmentally friendly skincare products. In this study, biogenically synthesized zinc oxide nanoparticles using Dendrobium anosum are used as a reducing and capping agent for topical anti-acne nanogels, and the antimicrobial effect of the nanogel is assessed on Cutibacterium acne and Staphylococcus aureus. Dendrobium anosmum leaf extract was examined for the presence of secondary metabolites and its total amount of phenolic and flavonoid content was determined. Both the biogenically and chemogenic-synthesized zinc oxide nanoparticles were compared using UV-Visible spectrophotometer, FE-SEM, XRD, and FTIR. To produce the topical nanogel, the biogenic and chemogenic zinc oxide nanoparticles were mixed with a carbomer and hydroxypropyl-methyl cellulose (HPMC) polymer. The mixtures were then tested for physical and chemical characteristics. To assess their anti-acne effectiveness, the mixtures were tested against C. acne and S. aureus. The biogenic zinc oxide nanoparticles have particle sizes of 20 nm and a high-phase purity. In comparison to chemogenic nanoparticles, the hydrogels with biogenically synthesized nanoparticles was more effective against Gram-positive bacteria. Through this study, the hybrid nanogels was proven to be effective against the microbes that cause acne and to be potentially used as a green product against skin infections. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles Synthesis and Antimicrobial Applications)
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25 pages, 12439 KiB  
Article
Limoniastrum monopetalum–Mediated Nanoparticles and Biomedicines: In Silico Study and Molecular Prediction of Biomolecules
by Afrah E. Mohammed, Sahar S. Alghamdi, Nada K. Alharbi, Fatma Alshehri, Rasha Saad Suliman, Fahad Al-Dhabaan and Maha Alharbi
Molecules 2022, 27(22), 8014; https://doi.org/10.3390/molecules27228014 - 18 Nov 2022
Cited by 4 | Viewed by 1805
Abstract
An in silico approach applying computer-simulated models helps enhance biomedicines by sightseeing the pharmacology of potential therapeutics. Currently, an in silico study combined with in vitro assays investigated the antimicrobial ability of Limoniastrum monopetalum and silver nanoparticles (AgNPs) fabricated by its aid. AgNPs [...] Read more.
An in silico approach applying computer-simulated models helps enhance biomedicines by sightseeing the pharmacology of potential therapeutics. Currently, an in silico study combined with in vitro assays investigated the antimicrobial ability of Limoniastrum monopetalum and silver nanoparticles (AgNPs) fabricated by its aid. AgNPs mediated by L. monopetalum were characterized using FTIR, TEM, SEM, and DLS. L. monopetalum metabolites were detected by QTOF–LCMS and assessed using an in silico study for pharmacological properties. The antibacterial ability of an L. monopetalum extract and AgNPs was investigated. PASS Online predictions and the swissADME web server were used for antibacterial activity and potential molecular target metabolites, respectively. Spherical AgNPs with a 68.79 nm average size diameter were obtained. Twelve biomolecules (ferulic acid, trihydroxy-octadecenoic acid, catechin, pinoresinol, gallic acid, myricetin, 6-hydroxyluteolin, 6,7-dihydroxy-5-methoxy 7-O-β-d-glucopyranoside, methyl gallate, isorhamnetin, chlorogenic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-l-mannopyranosyl)-β-d-glucopyranoside) were identified. The L. monopetalum extract and AgNPs displayed antibacterial effects. The computational study suggested that L. Monopetalum metabolites could hold promising antibacterial activity with minimal toxicity and an acceptable pharmaceutical profile. The in silico approach indicated that metabolites 8 and 12 have the highest antibacterial activity, and swissADME web server results suggested the CA II enzyme as a potential molecular target for both metabolites. Novel therapeutic agents could be discovered using in silico molecular target prediction combined with in vitro studies. Among L. Monopetalum metabolites, metabolite 12 could serve as a starting point for potential antibacterial treatment for several human bacterial infections. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles Synthesis and Antimicrobial Applications)
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10 pages, 1217 KiB  
Article
PMMA/ABS/CoCl2 Composites for Pharmaceutical Applications: Thermal, Antimicrobial, Antibiofilm, and Antioxidant Studies
by Muhammad Abid Zia, Muhammad Kaleem Khosa, Awal Noor, Sadaf Qayyum and Muhammad Shabbir Shakir
Molecules 2022, 27(22), 7669; https://doi.org/10.3390/molecules27227669 - 8 Nov 2022
Cited by 5 | Viewed by 1907
Abstract
In this study, PMMA/ABS/CoCl2 ternary composite films were fabricated by the solution casting technique. The different weight ratios of cobalt chloride (≤10 wt) were incorporated into the PMMA/ABS blend (80:20). The chemical structure and thermal properties of the synthesized composites were assessed [...] Read more.
In this study, PMMA/ABS/CoCl2 ternary composite films were fabricated by the solution casting technique. The different weight ratios of cobalt chloride (≤10 wt) were incorporated into the PMMA/ABS blend (80:20). The chemical structure and thermal properties of the synthesized composites were assessed by FT-IR, TGA, and XRD. The biological properties of ternary composites, such as in vitro antibacterial activity and antioxidant capacity, were investigated. The enhanced thermal stability and promising antibacterial, selective antibiofilm, and potential antioxidant properties of PMMA/ABS/cobalt chloride composites demonstrated that they can be used for high-quality plastics and in many pharmaceutical applications. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles Synthesis and Antimicrobial Applications)
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Graphical abstract

10 pages, 2122 KiB  
Article
Biogenic Silver Nanoparticles from Two Varieties of Agaricus bisporus and Their Antibacterial Activity
by Abeer M. Al-Dbass, Sooad Al Daihan, Aisha A. Al-Nasser, Leenah Saleh Al-Suhaibani, Jamilah Almusallam, Bushra Ibrahem Alnwisser, Sarah Saloum, Razan Sajdi Alotaibi, Laila Abdullah Alessa and Ramesa Shafi Bhat
Molecules 2022, 27(21), 7656; https://doi.org/10.3390/molecules27217656 - 7 Nov 2022
Cited by 13 | Viewed by 2136
Abstract
Agaricus bisporus, the most widely cultivated mushroom, is safe to eat and enriched with protein and secondary metabolites. We prepared silver nanoparticles (AgNPs) from two varieties of A. bisporus and tested their antibacterial activity The synthesized AgNPs were initially confirmed by UV-Vis [...] Read more.
Agaricus bisporus, the most widely cultivated mushroom, is safe to eat and enriched with protein and secondary metabolites. We prepared silver nanoparticles (AgNPs) from two varieties of A. bisporus and tested their antibacterial activity The synthesized AgNPs were initially confirmed by UV-Vis spectroscopy peaks at 420 and 430 nm for white and brown mushrooms AgNPs, respectively. AgNPs were further characterized by zeta sizer, transmission electronic microscopy (TEM), Fourier transform infrared (FTIR), and energy-dispersive X-ray spectroscopy (EDX) prior to antibacterial activity by the well diffusion method against six bacterial strains which include Staphylococcus aureus, Staphylococcus epidermis, Bacillus subtilis, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. TEM results revealed a spherical shape with an average diameter of about 11 nm in the white mushroom extract and 5 nm in the brown mushroom extract. The presence of elemental silver in the prepared AgNPs was confirmed by EDS. The IR spectrum of the extract confirmed the presence of phenols, flavonoids, carboxylic, or amide groups which aided in the reduction and capping of synthesized AgNPs. The AgNPs from both extracts showed almost the same results; however, nanoparticles prepared from brown mushrooms were smaller in size with strong antibacterial activity. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles Synthesis and Antimicrobial Applications)
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