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Ionic Liquids and Deep Eutectic Solvents in Catalysis: Current Status and Future Outlook

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 874

Special Issue Editors


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Guest Editor
Department of Organic and Inorganic Chemistry, School of Technology, Universidad de Extremadura, 10003 Cáceres, Spain
Interests: green chemistry; organic synthesis; catalysis ionic liquids; natural deep eutectic solvents; polymer modification; removal of organic pollutants
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Theoretical and Applied Catalysis Cluster, School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, Northern Ireland, UK
Interests: ionic liquids; deep eutectic solvents catalysis; green chemistry; organic synthesis

Special Issue Information

Dear Colleagues,

Organic synthesis is fundamental to societal progress, providing access to a wide range of essential compounds across various fields. In line with the principles of Green Chemistry, contemporary chemical research seeks to minimise its environmental impact.

One of the most promising and eco-friendly approaches involves using ionic liquids and deep eutectic solvents in catalysis. With their unique properties, such as negligible vapour pressure, thermal stability, and the ability to dissolve a wide range of compounds, these solvents have become versatile and efficient mediums in organic synthesis. They promote high yields and selectivities, significantly enhancing the sustainability of chemical processes.

The catalytic applications of ionic liquids and deep eutectic solvents span homogeneous, heterogeneous, and enzymatic catalysis, addressing specific challenges in synthetic processes. These applications improve reaction efficiency and reduce the reliance on harmful solvents. Furthermore, these solvents have demonstrated considerable potential in non-conventional energy activation methods, such as microwave and ultrasonic waves, optimising synthesis reactions by minimising by-products and waste.

This Special Issue aims to provide an open-access platform to present recent research advancements in applying ionic liquids and deep eutectic solvents in catalysis. It underscores their role in enhancing the efficiency and sustainability of organic synthesis reactions, emphasising their current status and future outlook in the field.

In this Special Issue, original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  1. Development of New Ionic Liquids (ILs) and Deep Eutectic Solvents (DESs) tailored for specific catalytic applications.
  2. Homogeneous Catalysis: Investigating ILs and DESs as solvents or co-solvents in homogeneous catalytic reactions.
  3. Heterogeneous Catalysis: Exploring the immobilisation of catalysts in ILs and DESs for heterogeneous catalytic processes.
  4. Enzymatic Catalysis: Application of ILs and DESs in enzymatic reactions to improve enzyme stability and activity.
  5. Green Chemistry and Sustainability: Evaluating the environmental impact and sustainability benefits of using ILs and DESs in catalytic processes.
  6. Non-Conventional Energy Activation: Use of ILs and DESs in catalysis under microwave, ultrasonic, or other non-conventional energy inputs to enhance reaction rates and selectivities.
  7. Reaction Mechanisms and Kinetics: Studying the mechanisms and kinetics of catalytic reactions in ILs and DESs.
  8. Industrial Applications: Case studies and applications of ILs and DESs in large-scale industrial catalytic processes.
  9. Recycling and Reusability: Research on ILs and DESs' recovery, recycling, and reuse in catalytic cycles.
  10. Comparative Studies: Comparing the efficiency of ILs and DESs with traditional solvents in various catalytic applications.
  11. Catalyst Design and Optimisation: Designing and optimising catalysts for use in ILs and DESs.
  12. Electrocatalysis and Photocatalysis: Application of ILs and DESs in electrochemical and photochemical catalytic processes.

We look forward to receiving your contributions.

Prof. Dr. Ignacio López-Coca
Dr. Peter A. Goodrich
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ionic liquids
  • deep eutectic solvents
  • green chemistry
  • catalysis
  • sustainable synthesis
  • homogeneous catalysis
  • heterogeneous catalysis
  • enzymatic catalysis
  • microwave irradiation
  • ultrasonic activation

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Published Papers (1 paper)

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Research

19 pages, 2924 KiB  
Article
Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids
by Susana Nieto, Inmaculada Lozano, Francisco J. Ruiz, Jose F. Costa, Rocio Villa and Pedro Lozano
Molecules 2024, 29(21), 5057; https://doi.org/10.3390/molecules29215057 - 26 Oct 2024
Viewed by 745
Abstract
Hydroxytyrosol (HT) is a nutraceutical compound, mainly found in the fruit, leaves and waste from the olive oil industry, known for exhibiting one of the highest antioxidant activities among molecules of natural origin. To harness this bioactivity in cosmetics, pharmaceuticals and the food [...] Read more.
Hydroxytyrosol (HT) is a nutraceutical compound, mainly found in the fruit, leaves and waste from the olive oil industry, known for exhibiting one of the highest antioxidant activities among molecules of natural origin. To harness this bioactivity in cosmetics, pharmaceuticals and the food industry, it is essential to modify the hydrophilicity of HT to enhance its compatibility with lipid-based mixtures. This chemical modification must be carried out with high selectivity to avoid compromising its radical scavenging activity. This work presents a highly efficient and selective approach to perform the biocatalytic esterification of free fatty acids (FFAs) of different alkyl chain lengths with HT in a reaction medium based on the SLIL [C12mim][NTf2]. By using a 1:2 (mol/mol) HT:FFA mixture of substrates, the HT-monoester derivative was obtained up to 77% yield after 2 h at 80 °C. The optimized molar ratio of substrates, combined with the ability to recover the SLIL for further reuse, significantly reduces waste accumulation compared to other reported strategies and results in a more sustainable approach as demonstrated by different green metrics. The antioxidant activity of HT-monoester products was fully maintained with respect to that presented by the natural HT, being stable for at least 3 months at 4 °C, as demonstrated by the DPPH and FRAP antioxidant analysis. Full article
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