State-of-the-Art Analytical Technologies for Metabolomics Analysis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Cross-Field Chemistry".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5105
Special Issue Editor
Special Issue Information
Dear Colleagues,
The term metabolome was first introduced in 1998. It refers to law-molecular-weight compounds crucial for biochemical changes occurring in living organisms. They can be produced directly by the organism or microorganisms inhabiting the host organism or delivered to the organism via different non-invasive or invasive methods. The rapid development of research in this area has proven that the pool of metabolites is much richer than initially anticipated and requires complex instrumental techniques to ensure high selectivity and sensitivity. Metabolites therefore present a distinct analytical challenge in which several issues must be taken into consideration to obtain adequately reliable results for both qualitative and quantitative analysis. These include thermal lability and chemical reactivity of metabolites leading to transformation of metabolites during subsequent steps of the analytical process (isolation from biological material, purification or even detection itself). The low molecular weights and high structural diversity of metabolites often require the use of high-performance separation techniques and molecule-specific spectrometers by analytical biochemists experienced in spectral interpretation and statistical analysis who must additionally overcome a shortage of standards for majority of metabolites. Over 20 years of practice in metabolomics allow us to define its limitations, strengths, and set directions for future development.
Therefore, this Special Issue aims to call for original research and review articles on overcoming analytical problems encountered in targeted and untargeted metabolomics, with an emphasis on the development of strategies required for qualitative and quantitative analysis.
Potential topics include but are not limited to:
- New methods for sample preparation, purification, and enrichment of metabolites;
- Development of un-targeted, semi-, and targeted strategies in metabolomics (analytical platforms);
- Identification and characterization of metabolites based on NMR and/or mass spectra analysis;
- Different approaches applied for quantitative analysis with the aim to improve accuracy or precision of the method or to solve the problem of standards deficiency.
I look forward to receiving your contributions.
Dr. Katarzyna Pawlak
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- targeted metabolomics
- untargeted metabolomics
- sample preparation
- isotopically labeled compounds
- mass spectrometry
- separation techniques
- NMR
- statistical analysis
- data visualization
- computational chemistry
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
