Antiproliferative and Anti-inflammatory Drugs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (23 September 2022) | Viewed by 9804
Special Issue Editors
Interests: drug design; small molecules; natural compounds; protein targeting; anticancer; antiviral; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Interests: drug stability; photodegradation; light-stable formulations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is a physiological response of the immune system to damaging stimuli, including pathogens, toxic compounds, irradiation, or altered cells. Uncontrolled inflammation may turn into a variety of more severe diseases involving several mediators of regulatory pathways. Several studies suggest that inflammation conditions could predispose individuals to develop cancer by promoting key stages of tumorigenesis.
Despite the recent progress in cancer research, there are still many concerns that need to be addressed in order to develop new and efficient therapeutics overcoming the side effects caused by conventional antineoplastic drugs.
New active molecules and handy drug-releasing devices are currently compelling research goals in medicinal chemistry. The definition of innovative and stable pharmaceutical formulations, able of optimize pharmacokinetic properties and protect drugs from degradation, represent new aspects being widely investigated. The monitoring system is nowadays regulated by the international guidelines from ICH (International Conference on Harmonization), which arranges the stability study of both a drug and its pharmaceutical forms.
This Special Issue aims to highlight current efforts in pharmaceutical chemistry and pharmacology towards innovative strategies against cancer and inflammation. Its content will focus on advanced drug discovery approaches by in silico identification of alternative natural and synthetic therapeutic agents, structure–activity relationships definition, and design of convenient synthetic strategies of new effective agents. Reports on the application of nanotechnologies and the biological and computational evaluation of newly synthesized or current drugs will be considered as well.
Dr. Fedora Grande
Dr. Giuseppina Ioele
Guest Editors
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Keywords
- natural and synthetic compounds
- drug design and synthesis
- pharmacophore modelling and dynamic simulations
- structure–activity relationships
- target validation
- biological evaluation
- drug Stability
- protective systems
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