Chitin and Chitosan Derivatives: Biological Activities and Application 2020
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 15976
Special Issue Editors
Interests: chitosan derivatives; chitosan conjugates; antimicrobials; drug delivery; nanoparticles; mathematical modeling
Special Issues, Collections and Topics in MDPI journals
2. Biomedical Engineering Department, Reykjavik University, 101 Reykjavík, Iceland
Interests: platelet lysates in biomaterial use; bone tissue engineering; bioreactors for bone tissue engineering
Special Issues, Collections and Topics in MDPI journals
Interests: new antimicrobial compounds as a solution for emerging diseases; chitosan and natural biopolymers with properties against human pathogenic filamentous fungi and yeast
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chitosan is a unique biopolymer that is derived from chitin. It can be polycationic under somewhat acidic conditions, and this separates it from other common polysaccharides that are either neutral or have a negative net charge in aqueous solutions. It is also biocompatible and has significant biological activity, most notably an antimicrobial effect, and has also been shown to stimulate tissue regeneration. Chitosan and chitooligosaccharides have been marked as neutraceuticals and used in wound treatment and in scaffolds for bone tissue engineering. There is also much interest in applications in drug delivery, including the use of chitosan as an absorption enhancer, in nanoparticles and non-viral gene delivery. Chemical modification of the chitin and chitosan backbone can be used to further expand the applicability and bioactivity of these biopolymers. Polar moieties can be introduced to improve solubility and biological activity under certain conditions, and conjugates with novel activities can created by covalent linking to other biomolecules. The derivatization of chitin and chitosan is now a very active research field, where new derivatives have been created using different approaches, including conventional synthesized chemical procedures, sometimes also involving the use of protection groups via ‘‘click chemistry“ or enzymatic grafting or by crosslinking to make biocompatible polymer networks.
The aim this Special Issue is to highlight these developments and bring toghether new findings related to biologically active chitin and chitosan derivatives. Reporting of new approaches for chemical modification and charactierization, including detailed structural characterization by NMR or other methods as well as exciting new findings with regard to biological activity and the application of chitin and chitosan derivatives, will be included in this Special Issue.
Dr. Már Másson
Prof. Ólafur Sigurjónsson
Guest Editors
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Keywords
- chitin
- chitosan
- chitooligosaccharides
- derivatives
- conjugates
- synthesis
- protection groups
- grafting
- click chemistry
- structure
- molecular weight
- NMR
- FT-IR
- X-ray
- SEC
- Mw
- antimicrobial
- regeneration
- cell growth
- tight-junction
- anti-cancer
- drug-delivery
- gene-delivery
- absorption
- wound healing
- bone growth
- nanoparticles
- hydrogels
- films
- membranes
- coatings
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