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Deep Eutectic Solvents in Organic Synthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 April 2019) | Viewed by 9076

Special Issue Editor


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Guest Editor
Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, USA
Interests: natural product synthesis; aurones; natural product dyes; deep eutectic solvents

Special Issue Information

Dear Colleagues, 

Deep Eutectic Solvents (DES) are an interesting family of solvents that have attracted attention as a less expensive and often less toxic alternative to room temperature ionic liquids. While many applications of DES have been explored, particularly their use in electroplating and metal recovery as well as natural product extraction, attention to their use as solvent replacements for conventional organic solvents in the area of synthesis has found less attention. This situation is unfortunate as earlier work demonstrated significant promise as DES are generally inexpensive and pose fewer hazards (low volatility and reduced risk of exposure), as well as some interesting opportunities for DES recycling and DES-based catalytic features that eliminate the need for other stoichiometric reagents. They could have particular benefit in many metal-catalyzed reactions as well as the reemerging area of electrosynthesis.

This Special Issue will provide an opportunity to publish research in the area of organic synthesis in DES, including catalyzed and solvent-catalyzed reactions, new and unusual reactions, and aspects related to recycling of the solvents and/or catalysts with the goal of promoting further research in this area.

Prof. Dr. Scott Handy
Guest Editor

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Keywords

  • Catalysis
  • Organic synthesis
  • Green synthesis
  • Organocatalysis
  • Transition metal catalysis
  • Solvent recycling

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Published Papers (1 paper)

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Research

14 pages, 4730 KiB  
Article
Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent
by Maria Luisa Di Gioia, Roberta Cassano, Paola Costanzo, Natividad Herrera Cano, Loredana Maiuolo, Monica Nardi, Fiore Pasquale Nicoletta, Manuela Oliverio and Antonio Procopio
Molecules 2019, 24(16), 2885; https://doi.org/10.3390/molecules24162885 - 8 Aug 2019
Cited by 48 | Viewed by 7853
Abstract
The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus [...] Read more.
The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction. Full article
(This article belongs to the Special Issue Deep Eutectic Solvents in Organic Synthesis)
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