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Nucleic Acids Chemistry: A Special Issue Celebrating the 75th Birthday of Prof. Makoto Komiyama

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 3713

Special Issue Editors


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Guest Editor
1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
2. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China
Interests: Z-DNA; Z-RNA; metabolism of nucleic acids; nutrition of nucleic acids; structure of nucleic acids; nucleic acids detection; circular nucleic acids; nucleic acids (nas); nanomaterials; chitosan
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Organization for Research and Development of Innovative Science and Technology (ORDIST), Kansai University, Suita 564-8680, Osaka, Japan
Interests: nucleic acid chemistry; DNA nanotechnology; supramolecular chemistry; molecular machines; molecular robotics; molecular technology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, China
Interests: nanostructures; self-assembly; molecular interface; sensors
Special Issues, Collections and Topics in MDPI journals
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
Interests: Z-DNA; Z-RNA; nucleic acid (NA) detection; structure of NA; circular DNA and RNA; NA circularization; DNAzyme; NA depurination

Special Issue Information

Dear Colleagues,

Nucleic acid (NA) chemistry has been well developed and has contributed greatly to the fields of life-science, biotechnology, and gene therapy. Many great discoveries have been closely related to NA chemistry, such as CRISPR-Cas9, NA vaccine, circular RNA, eccDNA, etc. To truly understand these interesting phenomena and develop their new applications, the corresponding chemistry will play a significant role in clarifying the corresponding molecular structures and working mechanisms in the future. Many excellent scientists are taking on these important and laborious tasks for the sake of science and technology, as well as the public. We are looking forward to summarizing the latest research to show the beauty and omnipotent function of nucleic acid molecules. The journal is pleased to announce that this issue is published as an honorary Special Issue in honor of Professor Makoto Komiyama for his outstanding contributions on nucleic acid chemistry on the occasion of his 75th birthday in 2022.

Professor Makoto Komiyama (born in 1947) is a world-famous nucleic acid chemist who is known for using artificial approaches to edit huge genome DNA, chemical modification of DNA and RNA, and DNA nanotechnology. He received his Ph.D. from The University of Tokyo in 1975. After spending four years at Northwestern University (Illinois, USA) as a postdoctoral fellow, he became an assistant professor at The University of Tokyo and then an associate professor at the University of Tsukuba. In 1991, he became a professor at The University of Tokyo. After retiring from The University of Tokyo in 2012, he spent four years at the University of Tsukuba, and two years at the National Institute for Materials Science, Tsukuba. From 2016–2020, he worked as a visiting professor in the Ocean University of China.

The journal is pleased to be publishing an honorary Special Issue in honor of Professor Makoto Komiyama for his outstanding contributions on nucleic acid chemistry on the occasion of his 75th birthday in 2022. This Special Issue of Molecules welcomes the submission of original, unpublished manuscripts on studies or reviews on the subject of nucleic acids and their derivatives.

Prof. Dr. Xingguo Liang
Prof. Dr. Akinori Kuzuya
Prof. Dr. Guoqing Wang
Dr. Ran An
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gene therapy
  • structure and function
  • chemical modification
  • biochemistry
  • molecular biology
  • medicine
  • gene expression
  • regulation

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Published Papers (1 paper)

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Review

25 pages, 4199 KiB  
Review
Mechanistic Aspects for the Modulation of Enzyme Reactions on the DNA Scaffold
by Peng Lin, Hui Yang, Eiji Nakata and Takashi Morii
Molecules 2022, 27(19), 6309; https://doi.org/10.3390/molecules27196309 - 24 Sep 2022
Cited by 8 | Viewed by 2651
Abstract
Cells have developed intelligent systems to implement the complex and efficient enzyme cascade reactions via the strategies of organelles, bacterial microcompartments and enzyme complexes. The scaffolds such as the membrane or protein in the cell are believed to assist the co-localization of enzymes [...] Read more.
Cells have developed intelligent systems to implement the complex and efficient enzyme cascade reactions via the strategies of organelles, bacterial microcompartments and enzyme complexes. The scaffolds such as the membrane or protein in the cell are believed to assist the co-localization of enzymes and enhance the enzymatic reactions. Inspired by nature, enzymes have been located on a wide variety of carriers, among which DNA scaffolds attract great interest for their programmability and addressability. Integrating these properties with the versatile DNA–protein conjugation methods enables the spatial arrangement of enzymes on the DNA scaffold with precise control over the interenzyme distance and enzyme stoichiometry. In this review, we survey the reactions of a single type of enzyme on the DNA scaffold and discuss the proposed mechanisms for the catalytic enhancement of DNA-scaffolded enzymes. We also review the current progress of enzyme cascade reactions on the DNA scaffold and discuss the factors enhancing the enzyme cascade reaction efficiency. This review highlights the mechanistic aspects for the modulation of enzymatic reactions on the DNA scaffold. Full article
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