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Plasma Technology and Biomedical Applications
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Plasma Technology and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 11561

Special Issue Editors

Dr. Dehui Xu

E-Mail Website
Guest Editor
Centre for Plasma Biomedicine, Xi’an Jiaotong University, Xi’an 710049, China
Interests: cold atmospheric plasma; cancer treatment; wound healing; clinical applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Wei Han

E-Mail Website
Guest Editor
Institute of Health and Medical Technology, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Hefei, China
Interests: non-thermal plasma; free radicals; cell death; anti-tumor immunity; radiotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the emerging technology of cold atmospheric plasma (CAP) has grown rapidly due to its many applications in biomedical fields such as wound healing, disinfection, hemostasis, dermatological treatment, and cancer treatment. Various kinds of reactive oxygen and nitrogen species generated by CAPs are considered important to their interactions with biological tissues. Therefore, it is pivotal to understand the generation and transformation of these reactive species by plasma discharging, as well as the relevant biological effects and clinical applications, particularly the corresponding molecular mechanisms and cell signal pathways involved in these biological processes.

We look forward to collecting research articles and review papers on the abovementioned topics for a Special Issue of Molecules entitled Plasma Technology and Biomedical Applications. We hope the papers in this Special Issue will be of high value to scientists working in the field of plasma medicine. We thank you for your efforts and contributions and look forward to receiving your valuable papers in the upcoming months.

Prof. Dr. Dehui Xu
Prof. Dr. Wei Han
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cold atmospheric plasma
  • non-thermal plasma
  • reactive species
  • wound healing
  • disinfection
  • hemostasis
  • dermatological treatment
  • cancer treatment
  • molecular mechanism
  • clinical trial

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Published Papers (6 papers)

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Research

15 pages, 3244 KiB  
Article
Helium Cold Atmospheric Plasma Causes Morphological and Biochemical Alterations in Candida albicans Cells
by Sabrina de Moura Rovetta-Nogueira, Aline Chiodi Borges, Maurício de Oliveira Filho, Thalita Mayumi Castaldelli Nishime, Luis Rogerio de Oliveira Hein, Konstantin Georgiev Kostov and Cristiane Yumi Koga-Ito
Molecules 2023, 28(23), 7919; https://doi.org/10.3390/molecules28237919 - 3 Dec 2023
Cited by 2 | Viewed by 1363
Abstract
(1) Background: Previous studies reported the promising inhibitory effect of cold atmospheric plasma (CAP) on Candida albicans. However, the exact mechanisms of CAP’s action on the fungal cell are still poorly understood. This study aims to elucidate the CAP effect on C. [...] Read more.
(1) Background: Previous studies reported the promising inhibitory effect of cold atmospheric plasma (CAP) on Candida albicans. However, the exact mechanisms of CAP’s action on the fungal cell are still poorly understood. This study aims to elucidate the CAP effect on C. albicans cell wall, by evaluating the alterations on its structure and biochemical composition; (2) Methods: C. albicans cells treated with Helium-CAP were analyzed by atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) in order to detect morphological, topographic and biochemical changes in the fungal cell wall. Cells treated with caspofungin were also analyzed for comparative purposes; (3) Results: Expressive morphological and topographic changes, such as increased roughness and shape modification, were observed in the cells after CAP exposure. The alterations detected were similar to those observed after the treatment with caspofungin. The main biochemical changes occurred in polysaccharides content, and an overall decrease in glucans and an increase in chitin synthesis were detected; (4) Conclusions: Helium-CAP caused morphological and topographic alterations in C. albicans cells and affected the cell wall polysaccharide content. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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14 pages, 4759 KiB  
Article
Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis
by Yuanyuan Zhou, Yan Zhang, Jie Bao, Jinwu Chen and Wencheng Song
Molecules 2022, 27(18), 5934; https://doi.org/10.3390/molecules27185934 - 13 Sep 2022
Cited by 5 | Viewed by 1958
Abstract
Low temperature plasma (LTP) is a promising cancer therapy in clinical practice. In this study, dielectric barrier discharge plasma with helium gas was used to generate LTP. Significant increases in extracellular and intracellular reactive species were found in lung cancer cells (CALU-1 and [...] Read more.
Low temperature plasma (LTP) is a promising cancer therapy in clinical practice. In this study, dielectric barrier discharge plasma with helium gas was used to generate LTP. Significant increases in extracellular and intracellular reactive species were found in lung cancer cells (CALU-1 and SPC-A1) after LTP treatments. Cells viability and apoptosis assays demonstrated that LTP inhibited cells viability and induced cells death, respectively. Moreover, Western blotting revealed that the growth of CALU-1 cells was suppressed by LTP via the VEGF/VEGFR2/RAS/ERK axis for the first time. The results showed that LTP-induced ROS and RNS could inhibit the growth of lung cancer cells via VEGF/VEGFR2/RAS/ERK axis. These findings advance our understanding of the inhibitory mechanism of LTP on lung cancer and will facilitate its clinical application. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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15 pages, 2233 KiB  
Article
Uncertainty Quantification and Sensitivity Analysis for the Electrical Impedance Spectroscopy of Changes to Intercellular Junctions Induced by Cold Atmospheric Plasma
by Jie Zhuang, Cheng Zhu, Rui Han, Anna Steuer, Juergen F. Kolb and Fukun Shi
Molecules 2022, 27(18), 5861; https://doi.org/10.3390/molecules27185861 - 9 Sep 2022
Cited by 2 | Viewed by 1565
Abstract
The influence of pertinent parameters of a Cole-Cole model in the impedimetric assessment of cell-monolayers was investigated with respect to the significance of their individual contribution. The analysis enables conclusions on characteristics, such as intercellular junctions. Especially cold atmospheric plasma (CAP) has been [...] Read more.
The influence of pertinent parameters of a Cole-Cole model in the impedimetric assessment of cell-monolayers was investigated with respect to the significance of their individual contribution. The analysis enables conclusions on characteristics, such as intercellular junctions. Especially cold atmospheric plasma (CAP) has been proven to influence intercellular junctions which may become a key factor in CAP-related biological effects. Therefore, the response of rat liver epithelial cells (WB-F344) and their malignant counterpart (WB-ras) was studied by electrical impedance spectroscopy (EIS). Cell monolayers before and after CAP treatment were analyzed. An uncertainty quantification (UQ) of Cole parameters revealed the frequency cut-off point between low and high frequency resistances. A sensitivity analysis (SA) showed that the Cole parameters, R0 and α were the most sensitive, while Rinf and τ were the least sensitive. The temporal development of major Cole parameters indicates that CAP induced reversible changes in intercellular junctions, but not significant changes in membrane permeability. Sustained changes of τ suggested that long-lived ROS, such as H2O2, might play an important role. The proposed analysis confirms that an inherent advantage of EIS is the real time observation for CAP-induced changes on intercellular junctions, with a label-free and in situ method manner. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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12 pages, 2174 KiB  
Article
Cold Atmospheric Plasma Suppressed MM In Vivo Engraftment by Increasing ROS and Inhibiting the Notch Signaling Pathway
by Miao Qi, Xinyi Zhao, Runze Fan, Xinying Zhang, Sansan Peng, Dehui Xu and Yanjie Yang
Molecules 2022, 27(18), 5832; https://doi.org/10.3390/molecules27185832 - 8 Sep 2022
Cited by 4 | Viewed by 1694
Abstract
Multiple myeloma (MM) is the second most common hematologic malignancy. MM stem cells (MMSCs) are thought to be the main causes of in vivo engraftment and eventual recurrence. As a notable new technology, cold atmospheric plasmas (CAPs) show a promising anti-tumor effect, due [...] Read more.
Multiple myeloma (MM) is the second most common hematologic malignancy. MM stem cells (MMSCs) are thought to be the main causes of in vivo engraftment and eventual recurrence. As a notable new technology, cold atmospheric plasmas (CAPs) show a promising anti-tumor effect, due to their production of various ROS. In this study, we found that different types of plasma could inhibit MM’s ability to form cell colonies, suppress MM in vivo engraftment, and extend survival times. We demonstrated that NAC (a ROS scavenger) could block ROS increases and reverse the inhibition of MM’s cell-colony-formation ability, which was induced by the plasma treatment. By using a stem cell signaling array, we found that the Notch pathway was inhibited by the plasma treatment; this was further confirmed by conducting real-time PCRs of three MM cell lines. Together, these results constitute the first report of plasma treatment inhibiting MM in vivo engraftment and prolonging survival time by suppressing the Notch pathway via ROS regulation. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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16 pages, 19021 KiB  
Article
Biological Risk Assessment of Three Dental Composite Materials following Gas Plasma Exposure
by Sander Bekeschus, Lea Miebach, Jonas Pommerening, Ramona Clemen and Katharina Witzke
Molecules 2022, 27(14), 4519; https://doi.org/10.3390/molecules27144519 - 15 Jul 2022
Cited by 2 | Viewed by 1976
Abstract
Gas plasma is an approved technology that generates a plethora of reactive oxygen species, which are actively applied for chronic wound healing. Its particular antimicrobial action has spurred interest in other medical fields, such as periodontitis in dentistry. Recent work has indicated the [...] Read more.
Gas plasma is an approved technology that generates a plethora of reactive oxygen species, which are actively applied for chronic wound healing. Its particular antimicrobial action has spurred interest in other medical fields, such as periodontitis in dentistry. Recent work has indicated the possibility of performing gas plasma-mediated biofilm removal on teeth. Teeth frequently contain restoration materials for filling cavities, e.g., resin-based composites. However, it is unknown if such materials are altered upon gas plasma exposure. To this end, we generated a new in-house workflow for three commonly used resin-based composites following gas plasma treatment and incubated the material with human HaCaT keratinocytes in vitro. Cytotoxicity was investigated by metabolic activity analysis, flow cytometry, and quantitative high-content fluorescence imaging. The inflammatory consequences were assessed using quantitative analysis of 13 different chemokines and cytokines in the culture supernatants. Hydrogen peroxide served as the control condition. A modest but significant cytotoxic effect was observed in the metabolic activity and viability after plasma treatment for all three composites. This was only partially treatment time-dependent and the composites alone affected the cells to some extent, as evident by differential secretion profiles of VEGF, for example. Gas plasma composite modification markedly elevated the secretion of IL6, IL8, IL18, and CCL2, with the latter showing the highest correlation with treatment time (Pearson’s r > 0.95). Cell culture media incubated with gas plasma-treated composite chips and added to cells thereafter could not replicate the effects, pointing to the potential that surface modifications elicited the findings. In conclusion, our data suggest that gas plasma treatment modifies composite material surfaces to a certain extent, leading to measurable but overall modest biological effects. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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11 pages, 1718 KiB  
Article
Canady Cold Helios Plasma Reduces Soft Tissue Sarcoma Viability by Inhibiting Proliferation, Disrupting Cell Cycle, and Inducing Apoptosis: A Preliminary Report
by Lawan Ly, Xiaoqian Cheng, Saravana R. K. Murthy, Olivia Z. Jones, Taisen Zhuang, Steven Gitelis, Alan T. Blank, Aviram Nissan, Mohammad Adileh, Matthew Colman, Michael Keidar, Giacomo Basadonna and Jerome Canady
Molecules 2022, 27(13), 4168; https://doi.org/10.3390/molecules27134168 - 29 Jun 2022
Cited by 4 | Viewed by 2110
Abstract
Soft tissue sarcomas (STS) are a rare and highly heterogeneous group of solid tumors, originating from various types of connective tissue. Complete removal of STS by surgery is challenging due to the anatomical location of the tumor, which results in tumor recurrence. Additionally, [...] Read more.
Soft tissue sarcomas (STS) are a rare and highly heterogeneous group of solid tumors, originating from various types of connective tissue. Complete removal of STS by surgery is challenging due to the anatomical location of the tumor, which results in tumor recurrence. Additionally, current polychemotherapeutic regimens are highly toxic with no rational survival benefit. Cold atmospheric plasma (CAP) is a novel technology that has demonstrated immense cancer therapeutic potential. Canady Cold Helios Plasma (CHCP) is a device that sprays CAP along the surgical margins to eradicate residual cancer cells after tumor resection. This preliminary study was conducted in vitro prior to in vivo testing in a humanitarian compassionate use case study and an FDA-approved phase 1 clinical trial (IDE G190165). In this study, the authors evaluate the efficacy of CHCP across multiple STS cell lines. CHCP treatment reduced the viability of four different STS cell lines (i.e., fibrosarcoma, synovial sarcoma, rhabdomyosarcoma, and liposarcoma) in a dose-dependent manner by inhibiting proliferation, disrupting cell cycle, and inducing apoptosis-like cell death. Full article
(This article belongs to the Special Issue Plasma Technology and Biomedical Applications)
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