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New Insights in Organic Radicals

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7586

Special Issue Editor


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Guest Editor
Department of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, Hubei, China
Interests: photoredox catalysis; nitrogen radical chemistry; asymmetric catalysis; cycloaddition; cross-coupling; heterocycle synthesis

Special Issue Information

Dear Colleagues,

Reactive free radicals and radical ions are some of the most important classes of reactive intermediates in the chemical, polymer, and biological sciences. Novel radical-mediated procedures, including cyclizations, cascades, radical-to-nucleophile couplings, and cyclizations, and radical-regulated catalytic systems with one or two electron donors are both equally exciting. They each have contributed to a notable flowering of innovative synthetic methodologies.

Molecules will join in and sponsor the third National Conference on Organic Radical Chemistry (http://www.orgradical3.cn/#1F). We also express our early congratulations regarding the great success of this conference.

Not only scientists who attend this symposium but also other radical chemists in China are cordially invited to contribute original research papers or reviews to this Special Issue titled “New Insights in Organic Radicals” of Molecules, which covers all areas of free radical chemistry, such as synthetic advances and applications; mechanistic insights; spectroscopic, structural, computational, and kinetic studies; as well as biochemical and electrochemical applications, among other topics.

Prof. Dr. Jia-Rong Chen
Guest Editor

Manuscript Submission Information

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Keywords

  • asymmetric synthesis
  • free radical chemistry
  • mechanism and application of free radical reaction

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Published Papers (2 papers)

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Research

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18 pages, 1821 KiB  
Article
Radical-Induced Cascade Annulation/Hydrocarbonylation for Construction of 2-Aryl-4H-chromen-4-ones
by Xinwei He, Keke Xu, Yanan Liu, Demao Wang, Qiang Tang, Wenjie Hui, Haoyu Chen and Yongjia Shang
Molecules 2022, 27(21), 7412; https://doi.org/10.3390/molecules27217412 - 1 Nov 2022
Cited by 4 | Viewed by 1777
Abstract
A robust metal- and solvent-free cascade radical-induced C-N cleavage/intramolecular 6-endo-dig annulation/hydrocarbonylation for the synthesis of the valuable 2-aryl-4H-chromen-4-ones is described. This practical synthesis strategy utilizes propargylamines and air as the oxygen source and green carbonylation reagent, in which propargylamines are [...] Read more.
A robust metal- and solvent-free cascade radical-induced C-N cleavage/intramolecular 6-endo-dig annulation/hydrocarbonylation for the synthesis of the valuable 2-aryl-4H-chromen-4-ones is described. This practical synthesis strategy utilizes propargylamines and air as the oxygen source and green carbonylation reagent, in which propargylamines are activated by the inexpensive and available dimethyl 2,2′-azobis(2-methylpropionate) (AIBME) and (PhSe)2 as the radical initiators. This simple and green protocol features wide substrate adaptability, good functional group tolerance, and amenability to scaling up and derivatizations. Full article
(This article belongs to the Special Issue New Insights in Organic Radicals)
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Review

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22 pages, 4930 KiB  
Review
Electroreductively Induced Radicals for Organic Synthesis
by Huaming Xiang, Jinyu He, Weifeng Qian, Mingqiang Qiu, Hao Xu, Wenxi Duan, Yanyan Ouyang, Yanzhao Wang and Cuiju Zhu
Molecules 2023, 28(2), 857; https://doi.org/10.3390/molecules28020857 - 15 Jan 2023
Cited by 17 | Viewed by 5279
Abstract
Organic electrochemistry has attracted tremendous interest within the novel sustainable methodologies that have not only reduced the undesired byproducts, but also utilized cleaner and renewable energy sources. Particularly, oxidative electrochemistry has gained major attention. On the contrary, reductive electrolysis remains an underexplored research [...] Read more.
Organic electrochemistry has attracted tremendous interest within the novel sustainable methodologies that have not only reduced the undesired byproducts, but also utilized cleaner and renewable energy sources. Particularly, oxidative electrochemistry has gained major attention. On the contrary, reductive electrolysis remains an underexplored research direction. In this context, we discuss advances in transition-metal-free cathodically generated radicals for selective organic transformations since 2016. We highlight the electroreductive reaction of alkyl radicals, aryl radicals, acyl radicals, silyl radicals, fluorosulfonyl radicals and trifluoromethoxyl radicals. Full article
(This article belongs to the Special Issue New Insights in Organic Radicals)
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