Structural Characterization of Marine-Derived Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2109
Special Issue Editors
Interests: configuration; chiral; chromatography; molecular computerize
Special Issues, Collections and Topics in MDPI journals
Interests: marine; microorganism; natural products; antibacterial; drug development
Special Issues, Collections and Topics in MDPI journals
Interests: marine natural products; synthetic biology; structural identification; natural pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organic molecules with chiral centers are commonly found in natural products research. Therefore, stereochemical elucidation of natural products is an important prerequisite for novel drug research and development. To date, many methods including general nuclear magnetic resonance parameters (NMR) spectroscopic experiment, chemical reactions, quantum chemical calculations, X-ray diffraction, and others or various combinations of these have been used to assign configurations of natural products. However, the configurations are still a challenge due to unstable conformations. Some compounds were not identified correctly. For example, some NOESY data could give a confused relationship because of the complex multiring system or more than one stable confirmation. Otherwise, there is a strong need for improving the configuration determination methods.
On the other hand, the configurations of the flexible structure are very difficult to achieve because of the special skeletons in which free rotation of the linear fragment due to C-C single bond generates much conformations and ultimately result in the difficulty of molecular configuration assignation. There are many trials to determine flexible structure configurations. However, except for chemical reactions and X-ray diffraction, these techniques are difficult to use for flexible molecules because they generate numerous complex and unpredictable conformations. Therefore, it is still a great challenge to accurately determine stereochemistry of flexible molecules, especially in the molecules with multiple chiral centers.
A correct configuration assignment of the right compound is crucial for the structure determination and related research. Additionally, it is an intriguing and state-of-the-art research topic.
Dr. Pinglin Li
Dr. Xiuli Xu
Dr. Faliang An
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- marine
- natural products
- bioassay
- dereplication
- structure characterization
- drug development
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
