Target-Specific Delivery of Gold and Ruthenium Complex to Cancer Cells: Where Are We?
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 414
Special Issue Editors
Interests: organometallic/inorganic chemistry; peptide chemistry; metal–peptide conjugates; interaction studies with biomolecules; anticancer drug design and development; drug delivery; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: molecular imaging; nuclear chemistry; radiopharmaceutical chemistry; theranostics; metallodrugs; peptides; targeted radionuclide therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is the second leading cause of death worldwide, and it is expected that in 20 years, there will be ~26 million new cancer cases. Despite the progress made in the last few years, cancer treatment, mainly focused on radiation therapy and chemotherapy, presents low therapeutic indices and a wide spectrum of severe side-effects, in part due to the little or no selectivity of drugs for cancer cells over nontumoral cells. Therefore, the need for alternative therapeutic options with improved selectivity is critical.
Following the clinical success achieved with platinum complexes, the search for metallodrugs with improved therapeutic properties has been extremely active within the bioinorganic/organometallic chemistry community. Among the large number of metal complexes with considerable anticancer properties, gold and ruthenium complexes are amongst the most promising alternatives. Nevertheless, this topic still remains a challenge to all scientists, especially those involved in the design of innovative metal-based target specific agents.
This Special Issue of Molecules welcomes original research articles, communications, and review articles dealing with major advancements and challenges of metallodrug discovery for cancer treatment. It will focus on design, identification, and evaluation of novel gold and ruthenium anticancer agents, biological targets, and targeting approaches.
Dr. Tânia S. Morais
Dr. João D. G. Correia
Guest Editors
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Keywords
- drug discovery
- drug design
- anticancer
- metallodrugs
- ruthenium
- gold
- targeting
- selectivity
- biological targets
- therapeutic approaches
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