Ultimate Insight into the COX Inhibition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (5 September 2021) | Viewed by 6609
Special Issue Editors
Interests: drug design; small molecules; natural compounds; protein targeting; anticancer; antiviral; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Non-steroidal analgetics find a wide range of applications due to their high efficacy and largely manageable unwanted effects. The identification and functional definition of COX-1 and COX-2 isozymes, the main targets of these drugs, have contributed to stimulate research in this field. The search of new active molecules and the study of handy drug-releasing devices are currently compelling goals in this area, while addressing the action of a drug by the attribution of peculiar pharmacokinetic properties and the design of innovative light-protected pharmaceutical forms represent two new aspects widely investigated.
This Special Issue aims to highlight the current efforts in pharmaceutical chemistry and pharmacology towards innovative strategies against inflammation. It welcomes works on advanced drug discovery approaches by in silico identification of alternative natural and synthetic COX ligands and on the study of structure–activity relationships and the design of convenient methods for the synthesis of effective agents. Nanotechnology applications and biological evaluation of anti-inflammatory therapies will be considered as well.
Dr. Fedora Grande
Prof. Dr. Antonio Garofalo
Guest Editors
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Keywords
- Natural and synthetic compounds
- Drug design
- Drug synthesis
- Pharmacophore modelling and dynamic simulations
- Structure–activity relationships
- Target validation
- Metabolic activation
- Hit discovery
- Hit-to-lead optimization
- Analytical techniques and methodologies
- Supramolecular chemistry
- Biological evaluation
- Photo-protective systems
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