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Nanomaterials
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Nanomaterials: Tools for Translational Applications
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Nanomaterials: Tools for Translational Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 26927

Special Issue Editors

Prof. Dr. Jose Luis Capelo

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Guest Editor
BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University Lisbon, Caparica, Portugal
Interests: antibiotic resistance; MALDI-TOF mass spectrometry; analytical proteomics; biomarker discovery; analytical chemistry; biochemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Javier Fernandez Lodeiro

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Guest Editor
LAQV-REQUIMTE—Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, Caparica, Portugal
Interests: chalcogenide materials; green methodologies; iron and nobel nanoparticles; rods and quantum dots
Special Issues, Collections and Topics in MDPI journals
Dr. Elisabete Oliveira

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Guest Editor
BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
Interests: bio-inspired chemosensors; luminescence; dye-doped polymers; antibiotic resistance; mesoporous silica nanoparticles; drug delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carlos Lodeiro

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Guest Editor
Chemistry Department, LAQV-REQUIMTE, NOVA Science and Technology School, NOVA University Lisbon, Lisbon, Portugal
Interests: environmental detection of pollutant toxic ions, cations, and molecules using chemosensors and sensors; development of new functionalized nanoparticles and nanomaterials; toxicological and bactericidal studies; personalized medicine; proteomics, especially studies involving the effect of the environment in health and wellbeing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are proud to announce a Special Issue, “Nanomaterials for Translational Applications”, in Nanomaterials (MDPI; IF 4.034) (https://www.mdpi.com/journal/nanomaterials) devoted to the 4th International Symposium on Nanoparticles, Nanomaterials and Applications (4thISN2A-2020) (http://www.isn2a2020.com/).

This Special Issue will select excellent papers from the oral (plenary, keynotes, and regular talks) and selected poster participations, and covers a very wide range of fields in nanomaterials applied in translational research, focusing on environmental, toxicological, imaging, drug delivery, new sustainable synthetic methods, and biomedical applications. We invite all the researchers to contribute original research articles, as well as review articles, to this Special Issue.

Prof. Carlos Lodeiro
Prof. Jose Luis Capelo
Dr. Javier Fernandez Lodeiro
Dr. Elisabete Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

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13 pages, 2981 KiB  
Article
Triboelectric Characterization of Colloidal TiO2 for Energy Harvesting Applications
by Erik Garofalo, Luca Cecchini, Matteo Bevione and Alessandro Chiolerio
Nanomaterials 2020, 10(6), 1181; https://doi.org/10.3390/nano10061181 - 17 Jun 2020
Cited by 13 | Viewed by 3240
Abstract
Nowadays, energy-related issues are of paramount importance. Every energy transformation process results in the production of waste heat that can be harvested and reused, representing an ecological and economic opportunity. Waste heat to power (WHP) is the process of converting the waste heat [...] Read more.
Nowadays, energy-related issues are of paramount importance. Every energy transformation process results in the production of waste heat that can be harvested and reused, representing an ecological and economic opportunity. Waste heat to power (WHP) is the process of converting the waste heat into electricity. A novel approach is proposed based on the employment of liquid nano colloids. In this work, the triboelectric characterization of TiO2 nanoparticles dispersed in pure water and flowing in a fluorinated ethylene propylene (FEP) pipe was conducted. The idea is to exploit the waste heat to generate the motion of colloidal TiO2 through a FEP pipe. By placing an Al ring electrode in contact with the pipe, it was possible to accumulate electrostatic charges due to the triboelectric effect between the fluid and the inner pipe walls. A peristaltic pump was used to drive and control the flow in order to evaluate the performances in a broad fluid dynamic spectrum. The system generated as output relatively high voltages and low currents, resulting in extracted power ranging between 0.4 and 0.6 nW. By comparing the power of pressure loss due to friction with the extracted power, the electro-kinetic efficiency was estimated to be 20%. Full article
(This article belongs to the Special Issue Nanomaterials: Tools for Translational Applications)
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11 pages, 12843 KiB  
Article
Fast Degradation of Bisphenol A in Water by Nanostructured CuNPs@CALB Biohybrid Catalysts
by Noelia Losada-Garcia, Alba Rodriguez-Otero and Jose M. Palomo
Nanomaterials 2020, 10(1), 7; https://doi.org/10.3390/nano10010007 - 18 Dec 2019
Cited by 9 | Viewed by 3306
Abstract
Copper nanoparticles–enzyme biohybrid is a promising material for the remediation of contaminated waters, but its function is influenced by its effect on degradation organic pollutants. This study is the first investigation into the fast degradation of a high amount of Bisphenol A (BPA) [...] Read more.
Copper nanoparticles–enzyme biohybrid is a promising material for the remediation of contaminated waters, but its function is influenced by its effect on degradation organic pollutants. This study is the first investigation into the fast degradation of a high amount of Bisphenol A (BPA) in water at neutral pH and room temperature. Four different CuNPs biohybrids with different cu species and nanoparticle sizes were used as catalysts. The biohybrid CuNPs@CALB-3, which contained Cu2O nanoparticles of around 10 nm size, showed excellent catalytic performance removing >95% BPA content (45 ppm) in an aqueous solution in 20 min in the presence of hydrogen peroxide at pH 8 using 1.5 g/L of a catalyst. The catalyst showed excellent stability and recyclability at these conditions. Full article
(This article belongs to the Special Issue Nanomaterials: Tools for Translational Applications)
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Review

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57 pages, 6402 KiB  
Review
Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics
by Alexandra Mavridi-Printezi, Moreno Guernelli, Arianna Menichetti and Marco Montalti
Nanomaterials 2020, 10(11), 2276; https://doi.org/10.3390/nano10112276 - 17 Nov 2020
Cited by 54 | Viewed by 7374
Abstract
Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical [...] Read more.
Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology. Full article
(This article belongs to the Special Issue Nanomaterials: Tools for Translational Applications)
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30 pages, 3511 KiB  
Review
From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research
by Indra Van Zundert, Beatrice Fortuni and Susana Rocha
Nanomaterials 2020, 10(11), 2236; https://doi.org/10.3390/nano10112236 - 11 Nov 2020
Cited by 61 | Viewed by 12214
Abstract
Over the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant advances, well-designed nanoparticles rarely reach the clinical stage. Promising results obtained [...] Read more.
Over the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant advances, well-designed nanoparticles rarely reach the clinical stage. Promising results obtained in standard 2D cell culture systems often turn into disappointing outcomes in in vivo models. Although the overall majority of in vitro nanoparticle research is still performed on 2D monolayer cultures, more and more researchers started acknowledging the importance of using 3D cell culture systems, as better models for mimicking the in vivo tumor physiology. In this review, we provide a comprehensive overview of the 3D cancer cell models currently available. We highlight their potential as a platform for drug delivery studies and pinpoint the challenges associated with their use. We discuss in which way each 3D model mimics the in vivo tumor physiology, how they can or have been used in nanomedicine research and to what extent the results obtained so far affect the progress of nanomedicine development. It is of note that the global scientific output associated with 3D models is limited, showing that the use of these systems in nanomedicine investigation is still highly challenging. Full article
(This article belongs to the Special Issue Nanomaterials: Tools for Translational Applications)
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