Emergent Applications of Peptide and Protein Nanotechnology

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3043

Special Issue Editor


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Guest Editor
Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
Interests: peptide and protein nanotechnology; peptide materials; spectroscopy of biomolecules; peptide self-assembly; porphyrin aggregation and nanostructures
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Special Issue Information

Dear Colleagues,

Peptides and proteins are fundamental components of the cellular machinery. With the idea of mimicking the functional properties of these versatile biological engines, the last decade has witnessed an explosion of interest in nanotechnological applications of peptides and proteins as smart biomaterials. The advancement of knowledge has been impressive on both the fundamental side (mechanisms of growth of peptide nanostructures, controlled self-assembly of proteins, rational design of multi-component systems) and in applications (nanocatalysis, biosensing, biohybrid devices, nanomedicine). It is now time for a comprehensive survey of the applications springing from this exciting field, and I am grateful to Nanomaterials for the opportunity to be guest editor for a Special Issue dedicated to ‘Emergent Applications of Peptide and Protein Nanotechnology’.

This Special Issue is open to contributions on: (a) biomedical applications of peptide and protein nanostructures for therapy, prevention, and diagnostics; (b) peptides and proteins as functional components of nanostructured materials (nanotubes, nanoparticles, ultrathin films, nanofibers); (c) the rational design, properties, and applications  of peptide- and protein-based materials;  (d) peptide and protein hybrid materials; (e) peptide and protein networks, interfaces, and supramolecular complexes; and (f) computational approaches to the design of peptide and protein nanostructures. Our contributors are leading scientists from the bionanoworld, i.e., nanomedicine, biomaterials science, bionanoengineering, and bionanotechnology.

Prof. Dr. Mariano Venanzi
Guest Editor

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Keywords

  • peptide and protein nanotechnology
  • peptide and protein-based materials
  • peptide and protein nanostructures
  • bioinspired nanotechnology

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Published Papers (1 paper)

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Research

21 pages, 3515 KiB  
Article
Effectiveness of Direct Laser Interference Patterning and Peptide Immobilization on Endothelial Cell Migration for Cardio-Vascular Applications: An In Vitro Study
by Romain Schieber, Carlos Mas-Moruno, Federico Lasserre, Joan Josep Roa, Maria-Pau Ginebra, Frank Mücklich and Marta Pegueroles
Nanomaterials 2022, 12(7), 1217; https://doi.org/10.3390/nano12071217 - 5 Apr 2022
Cited by 5 | Viewed by 2509
Abstract
Endothelial coverage of an exposed cardiovascular stent surface leads to the occurrence of restenosis and late-stent thrombosis several months after implantation. To overcome this difficulty, modification of stent surfaces with topographical or biochemical features may be performed to increase endothelial cells’ (ECs) adhesion [...] Read more.
Endothelial coverage of an exposed cardiovascular stent surface leads to the occurrence of restenosis and late-stent thrombosis several months after implantation. To overcome this difficulty, modification of stent surfaces with topographical or biochemical features may be performed to increase endothelial cells’ (ECs) adhesion and/or migration. This work combines both strategies on cobalt-chromium (CoCr) alloy and studies the potential synergistic effect of linear patterned surfaces that are obtained by direct laser interference patterning (DLIP), coupled with the use of Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) peptides. An extensive characterization of the modified surfaces was performed by using AFM, XPS, surface charge, electrochemical analysis and fluorescent methods. The biological response was studied in terms of EC adhesion, migration and proliferation assays. CoCr surfaces were successfully patterned with a periodicity of 10 µm and two different depths, D (≈79 and 762 nm). RGD and YIGSR were immobilized on the surfaces by CPTES silanization. Early EC adhesion was increased on the peptide-functionalized surfaces, especially for YIGSR compared to RGD. High-depth patterns generated 80% of ECs’ alignment within the topographical lines and enhanced EC migration. It is noteworthy that the combined use of the two strategies synergistically accelerated the ECs’ migration and proliferation, proving the potential of this strategy to enhance stent endothelialization. Full article
(This article belongs to the Special Issue Emergent Applications of Peptide and Protein Nanotechnology)
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