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Nutrients
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Featured Reviews on Infant Nutrition and Allergic Disease
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Featured Reviews on Infant Nutrition and Allergic Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 4129

Special Issue Editors

Prof. Dr. Antonella Muraro

E-Mail Website
Guest Editor
Food Allergy Referral Centre, Padua University Hospital, 35128 Padua, Italy
Interests: food allergy; food immunotherapy; anaphyaxis; atopic dermatitis; allergies in pediatric age
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carina Venter

E-Mail Website
Guest Editor
Section of Allergy & Immunology, School of Medicine, University of Colorado Denver, Children’s Hospital Colorado, Anschutz Medical Campus, 13123 East 16th Avenue, Aurora, CO 80045, USA
Interests: food allergy; food immunotherapy; anaphyaxis; nutrients; allergic disease

Special Issue Information

Dear Colleagues,

The prevalence of asthma and allergic diseases has increased dramatically over the past few decades with the highest incidence occurring in children. Most asthma and related atopic disorders have their origins in early life. Thus, it is imperative to understand the early life origins of the disease in order to identify targets for its prevention and early intervention. Food allergy is often one of the earliest manifestations of atopy, and the sensitization to food is a risk factor for the subsequent appearance of respiratory allergy and asthma. 

A nutritional approach represents an important step in food allergy management, with the aim of satisfying the needs of macro- and micronutrients, while maintaining a well-balanced diet. Besides the traditional approach, which involves avoiding the harmful foods, a novel paradigm shift is currently under way with the spread of oral tolerance induction as a concept in allergy therapy. In recent years, the dietary management of allergic diseases has thus moved from a passive approach, consisting of an elimination diet to relieve symptoms, to a “proactive” one, with the possibility of actively modulating the immune system by dietary intervention.

The purpose of this Special Issue of Nutrients is to provide an overview of how nutrition may impact allergic diseases. More specifically, this Special Issue addresses how dietary factors, a varied diet, and dietary patterns may affect allergic outcomes. The importance of supplying adequate dietary intake in managing food allergies is also highlighted. Furthermore, the recent developments in actively managing and treating food allergies are summarized.

Prof. Dr. Antonella Muraro
Prof. Dr. Carina Venter
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • infant nutrition
  • pediatric nutrition
  • immune nutrition
  • dietary intake

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Published Papers (2 papers)

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Review

22 pages, 1688 KiB  
Review
Transplant-Acquired Food Allergy in Children
by Cristiana Indolfi, Angela Klain, Giulio Dinardo, Carolina Grella, Alessandra Perrotta, Simone Colosimo, Fabio Decimo and Michele Miraglia del Giudice
Nutrients 2024, 16(18), 3201; https://doi.org/10.3390/nu16183201 - 22 Sep 2024
Viewed by 1233
Abstract
Background: Organ transplantation in children is a vital procedure for those with end-stage organ failure, but it has been linked to the development of post-transplant allergies, especially food allergies. This phenomenon, known as transplant-acquired food allergy (TAFA), is becoming increasingly recognized, though its [...] Read more.
Background: Organ transplantation in children is a vital procedure for those with end-stage organ failure, but it has been linked to the development of post-transplant allergies, especially food allergies. This phenomenon, known as transplant-acquired food allergy (TAFA), is becoming increasingly recognized, though its mechanisms remain under investigation. Pediatric transplant recipients often require lifelong immunosuppressive therapy to prevent graft rejection, which can alter immune function and heighten the risk of allergic reactions. Our review aimed to gather the latest evidence on TAFA. Methods: We conducted a PubMed search from 25 June to 5 July 2024, using specific search terms, identifying 143 articles. After screening, 36 studies were included: 24 retrospective studies, 1 prospective study, 2 cross-sectional researches, and 9 case reports/series. Results: Most studies focused on liver transplants in children. The prevalence of food allergies ranged from 3.3% to 54.3%. Tacrolimus, alongside corticosteroids, was the most commonly used immunosuppressive therapy. In addition to food allergies, some patients developed atopic dermatitis, asthma, and rhinitis. Allergic symptoms typically emerged within a year post-transplant, with common allergens including milk, eggs, fish, nuts, soy, wheat, and shellfish. Both IgE-mediated and non-IgE-mediated reactions were observed, with treatment often involving the removal of offending foods and the use of adrenaline when necessary. Conclusions: Consistent immunological monitoring, such as skin prick tests and IgE level assessments, is essential for early detection and management of allergies in these patients. Understanding the link between transplantation and allergy development is crucial for improving long-term outcomes for pediatric transplant recipients. Full article
(This article belongs to the Special Issue Featured Reviews on Infant Nutrition and Allergic Disease)
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18 pages, 1024 KiB  
Review
Redefining the Role of Nutrition in Infant Food Allergy Prevention: A Narrative Review
by Michael Brandwein, Roni Enten Vissoker, Helen Jackson, Tavierney Rogan, Jana Pitcock, Esther Krinkin and Carina Venter
Nutrients 2024, 16(6), 838; https://doi.org/10.3390/nu16060838 - 14 Mar 2024
Cited by 2 | Viewed by 2491
Abstract
Pediatric food allergy remains commonplace, despite the advancement in our understanding of risk factors and prevention modalities for the condition. Early allergen introduction, a dietary intervention, has been endorsed by professional societies globally as an effective primary preventive measure, yet awareness among medical [...] Read more.
Pediatric food allergy remains commonplace, despite the advancement in our understanding of risk factors and prevention modalities for the condition. Early allergen introduction, a dietary intervention, has been endorsed by professional societies globally as an effective primary preventive measure, yet awareness among medical professionals and parents is lacking. Alongside food allergen introduction, overall nutrition, such as diet diversity, also plays an important role in allergy prevention. To address both food allergen introduction and overall nutrition, dietitians play a pivotal role in the dissemination and education of current guidelines to caregivers. This review addresses the particular role of the dietitian in food allergy prevention consultations, providing up-to-date information on food allergies, their development and prevalence, risk factors, dietary factors and an overview of the current guidelines in the United States. This has not been addressed in any of the current food allergy or nutrition guidelines. Full article
(This article belongs to the Special Issue Featured Reviews on Infant Nutrition and Allergic Disease)
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