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Nutraceuticals, Bioactive Compounds and Functional Foods: Their Role in Chronic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 April 2025 | Viewed by 2403

Special Issue Editors


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Guest Editor
Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Centre, University of Granada, 18016 Armilla, Spain
Interests: aging; natural products; neurodegenerative diseases; nutrition; redox biology

E-Mail Website
Guest Editor
Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Centre, University of Granada, 18016 Armilla, Spain
Interests: aging; mitochondria; redox biology; foods; nutrition; age-related diseases; oral health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the intersection of nutrition, health, and disease prevention has garnered increasing attention from scholars and practitioners. As life expectancy increases globally, so does the burden of noncommunicable diseases, also known as chronic diseases. This underscores the urgent need to implement strategies to reduce their occurrence and negative impacts. Among the primary chronic diseases are cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases.

The advent of nutraceuticals, bioactive compounds, and functional foods represents a promising frontier in combating chronic diseases. Nutraceuticals, characterized by their therapeutic properties, offer a novel approach to complementing traditional healthcare practices. Similarly, bioactive compounds found abundantly in various natural sources possess remarkable potential in modulating biological processes implicated in chronic diseases. Moreover, functional foods fortified with specific nutrients or bioactive ingredients present a convenient and accessible means of promoting health and wellbeing.

The Special Issue “Nutraceuticals, Bioactive Compounds and Functional Foods: Their Role in Chronic Diseases” of Nutrients aims to explore the multifaceted roles of bioactive compounds and foods in addressing a spectrum of chronic ailments, ranging from cardiovascular diseases and diabetes to cancer and neurodegenerative disorders. Contributions to this Special Issue, in the form of original research, both in vitro and in vivo, as well as review or meta-analysis articles are welcome.

Dr. María D. Navarro-Hortal
Dr. Alfonso Varela-López
Guest Editors

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Keywords

  • bioactive compounds
  • polyphenols
  • nutraceuticals
  • nutrition
  • foods
  • diet
  • chronic diseases
  • cardiovascular diseases
  • pulmonary disease chronic obstructive
  • autoimmune diseases
  • inflammatory bowel diseases
  • chronic kidney disease
  • fatty liver
  • neoplasms
  • neurodegenerative diseases
  • diabetes mellitus
  • chronic periodontitis

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Published Papers (1 paper)

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Review

35 pages, 848 KiB  
Review
Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights
by Kajita Piriyaprasath, Yoshito Kakihara, Mana Hasegawa, Yuya Iwamoto, Yoko Hasegawa, Noritaka Fujii, Kensuke Yamamura and Keiichiro Okamoto
Nutrients 2024, 16(17), 2868; https://doi.org/10.3390/nu16172868 - 27 Aug 2024
Viewed by 1854
Abstract
This narrative review provides an overview of current knowledge on the impact of nutritional strategies on chronic craniofacial pain associated with temporomandibular disorders (TMDs). Individuals experiencing painful TMDs alter their dietary habits, avoiding certain foods, possibly due to chewing difficulties, which might lead [...] Read more.
This narrative review provides an overview of current knowledge on the impact of nutritional strategies on chronic craniofacial pain associated with temporomandibular disorders (TMDs). Individuals experiencing painful TMDs alter their dietary habits, avoiding certain foods, possibly due to chewing difficulties, which might lead to nutrient deficiencies. Our literature investigation revealed that the causal links between nutritional changes and craniofacial pain remain unclear. However, clinical and preclinical studies suggest that nutraceuticals, including vitamins, minerals, polyphenols, omega-3 fatty acids, isoprenoids, carotenoids, lectins, polysaccharides, glucosamines, and palmitoylethanolamides, could have beneficial effects on managing TMDs. This is described in 12 clinical and 38 preclinical articles since 2000. Clinical articles discussed the roles of vitamins, minerals, glucosamine, and palmitoylethanolamides. The other nutraceuticals were assessed solely in preclinical studies, using TMD models, mostly craniofacial inflammatory rodents, with 36 of the 38 articles published since 2013. Our investigation indicates that current evidence is insufficient to assess the efficacy of these nutraceuticals. However, the existing data suggest potential for therapeutic intervention in TMDs. Further support from longitudinal and randomized controlled studies and well-designed preclinical investigations is necessary to evaluate the efficacy of each nutraceutical intervention and understand their underlying mechanisms in TMDs. Full article
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