Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.2
4.8
Journals
Nutrients
Special Issues
Dietary Management and Nutritional Health for Age-Related Diseases
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Dietary Management and Nutritional Health for Age-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 12535

Special Issue Editors

Dr. Yoo Kim

E-Mail Website
Guest Editor
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA
Interests: aging; obesity; type 2 diabetes; food bioactive compound; nutrigenomics; insulin signaling pathway
Special Issues, Collections and Topics in MDPI journals
Dr. Byungyong Ahn

E-Mail Website
Guest Editor
Department of Food Science and Nutrition, University of Ulsan, Ulsan 44610, Republic of Korea
Interests: metabolic diseases; insulin resistance; obesity; diabetes; glucose metabolism; lipid metabolism; aging; sarcopenia; cardiac, muscle and liver energy metabolism; mitochondria
Special Issues, Collections and Topics in MDPI journals
Dr. Xian Wu

E-Mail Website
Guest Editor
Department of Kinesiology, Nutrition, and Health, Miami University, Oxford, OH 45056, USA
Interests: food bioactives; functional foods; obesity; colorectal cancer; chronic disease pre-vention; aging; gut microbiota
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aging is a condition that loses the ability to maintain homeostasis due to dysfunction. Various factors influence the aging process, but so far, dietary management, lifestyle change and physical exercise are the only known mediators, except for genetic factors that lead to a delay or prevent age-related diseases. The purpose of this Special Issue, “Dietary Management and Nutritional Health for Age-related Diseases,” is to provide cutting-edge original research and review articles regarding the diverse properties of various vitamins in disease and healthy living conditions. This Special Issue will discuss the potential role of functional foods, dietary interventions including calorie control restriction, intermittent fasting, time-restricted eating and fasting-mimicking diets, and patterns such as ketogenic, Mediterranean, DASH and MIND diets on age-associated diseases. Articles addressing metabolic syndrome, inflammation (inflammaging) and neurodegenerative diseases are encouraged. Submissions as original research articles and reviews including system reviews are welcome.

Dr. Yoo Kim
Dr. Byungyong Ahn
Dr. Xian Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • age-related diseases
  • dietary management
  • dietary pattern
  • dietary intervention
  • functional food
  • food bioactive compound

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 2122 KiB  
Article
Filbertone Reduces Senescence in C2C12 Myotubes Treated with Doxorubicin or H2O2 through MuRF1 and Myogenin
by Sumin Jung and Byungyong Ahn
Nutrients 2024, 16(18), 3177; https://doi.org/10.3390/nu16183177 - 19 Sep 2024
Viewed by 1185
Abstract
It has been demonstrated that filbertone, the principal flavor compound of hazelnuts, exhibits preventive effects against hypothalamic inflammation, obesity, neurodegenerative diseases, and muscle lipid accumulation. However, its influence on muscle aging has yet to be elucidated. The objective of this study was to [...] Read more.
It has been demonstrated that filbertone, the principal flavor compound of hazelnuts, exhibits preventive effects against hypothalamic inflammation, obesity, neurodegenerative diseases, and muscle lipid accumulation. However, its influence on muscle aging has yet to be elucidated. The objective of this study was to investigate the effects of filbertone on muscle aging in C2C12 myotubes subjected to senescence induction by either doxorubicin or hydrogen peroxide. To ascertain the mechanisms by which filbertone exerts its effects, we conducted a series of experiments, including Western blot analysis, reverse transcription quantitative polymerase chain reaction (qRT-PCR), and senescence-associated β-galactosidase (SA-β-gal) staining. Filbertone was markedly observed to decrease not only the protein levels of p53 (p < 0.01) in senescence-induced skeletal muscle cells, but also the gene expression levels of p21 (p < 0.05), a direct target of p53. The expression of muscle-related genes, including myogenin and muscle RING-finger protein-1 (MuRF1), was found to be significantly enhanced in senescent muscle cells following treatment with filbertone (p < 0.05). In addition, the number of senescent skeletal muscle cells exhibiting β-galactosidase activity was found to be markedly reduced in the presence of filbertone (p < 0.01). Collectively, these findings suggest that filbertone plays a pivotal role in the regulation of muscle aging. Full article
(This article belongs to the Special Issue Dietary Management and Nutritional Health for Age-Related Diseases)
►▼ Show Figures

Figure 1

10 pages, 252 KiB  
Article
Lack of Association between Insufficient Intake of Multiple Vitamins and Frailty in Older Adults Who Consume Sufficient Energy and Protein: A Nationwide Cross-Sectional Study
by Seung-Guk Park and Hyoeun Kim
Nutrients 2024, 16(16), 2586; https://doi.org/10.3390/nu16162586 - 6 Aug 2024
Viewed by 1189
Abstract
Frailty is a complex condition that intensifies with age and is marked by decreased physiological function. We rigorously investigated the effects of lower vitamin intake on frailty using data from 665 adults aged over 65 years who consumed sufficient recommended daily energy and [...] Read more.
Frailty is a complex condition that intensifies with age and is marked by decreased physiological function. We rigorously investigated the effects of lower vitamin intake on frailty using data from 665 adults aged over 65 years who consumed sufficient recommended daily energy and protein intakes from the Korean Nutrition and Health Survey, 2016–2019. The definition of frailty was modified based on Fried et al.’s definition of weight loss, exhaustion, weakness, slowness, and low energy expenditure. Based on daily intake, we analyzed vitamins such as vitamin A, thiamine, riboflavin, niacin, folic acid, and vitamin C. Our results of logistic regression showed that increasing multiple deficiencies in several kinds of vitamins (mild to moderate to severe) is not associated with frailty (odds ratio: 1, 1.24 (0.24–3.10), 0.82 (0.28–2.39), p for trend = 0.626) in older adults who consumed sufficient calories and proteins. A subgroup analysis of age and sex, which may interfere with the relationship between vitamin intake and frailty, showed that vitamin intake was not associated with frailty when sufficient energy and proteins were consumed. Furthermore, there was no difference in the prevalence of frailty between the groups with sufficient and insufficient intakes of individual vitamins. Full article
(This article belongs to the Special Issue Dietary Management and Nutritional Health for Age-Related Diseases)
►▼ Show Figures

Graphical abstract

17 pages, 8394 KiB  
Article
Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer’s Disease-Induced (3xTg-AD) Mice
by Gopal Lamichhane, Jing Liu, Su-Jeong Lee, Da-Yeon Lee, Guolong Zhang and Yoo Kim
Nutrients 2024, 16(2), 240; https://doi.org/10.3390/nu16020240 - 12 Jan 2024
Cited by 8 | Viewed by 3964
Abstract
The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer’s disease (AD) incidence. This study aimed to access the protective effects of curcumin, a bioactive flavonoid from turmeric, on spatial memory, metabolic functions, and [...] Read more.
The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer’s disease (AD) incidence. This study aimed to access the protective effects of curcumin, a bioactive flavonoid from turmeric, on spatial memory, metabolic functions, and the regulation of the gut microbiome in AD-induced (3xTg-AD) mice fed with either a normal chow diet (NCD) or a high-fat high-sugar diet (HFHSD). Our findings revealed an augmented susceptibility of the HFHSD-fed 3xTg-AD mice for weight gain and memory impairment, while curcumin supplementation demonstrated a protective effect against these changes. This was evidenced by significantly reduced body weight gain and improved behavioral and cognitive function in the curcumin-treated group. These improvements were substantiated by diminished fatty acid synthesis, altered cholesterol metabolism, and suppressed adipogenesis-related pathways in the liver, along with modified synaptic plasticity-related pathways in the brain. Moreover, curcumin enriched beneficial gut microbiota, including Oscillospiraceae and Rikenellaceae at the family level, and Oscillibacter, Alistipes, Pseudoflavonifractor, Duncaniella, and Flintibacter at the genus level. The observed alteration in these gut microbiota profiles suggests a potential crosswalk in the liver and brain for regulating metabolic and cognitive functions, particularly in the context of obesity-associated cognitive disfunction, notably AD. Full article
(This article belongs to the Special Issue Dietary Management and Nutritional Health for Age-Related Diseases)
►▼ Show Figures

Figure 1

18 pages, 1128 KiB  
Article
Beneficial Effects of Oral Nutrition Supplements on the Nutritional Status and Physical Performance of Older Nursing Home Residents at Risk of Malnutrition
by Yi-Hsiu Chen, Che-Yu Lee, Jiun-Rong Chen, Min-Yu Ding, Feng-Qi Liang and Suh-Ching Yang
Nutrients 2023, 15(19), 4291; https://doi.org/10.3390/nu15194291 - 8 Oct 2023
Cited by 2 | Viewed by 3096
Abstract
The purpose of this study was to compare the effects of nutritional supplement drinks (NSDs) and nutritional education (NE) on the nutritional status and physical performance of older nursing home residents who were at risk of malnutrition. This study was a clustered, randomized, [...] Read more.
The purpose of this study was to compare the effects of nutritional supplement drinks (NSDs) and nutritional education (NE) on the nutritional status and physical performance of older nursing home residents who were at risk of malnutrition. This study was a clustered, randomized, parallel, multi-center clinical trial, with 107 participants more than 65 years old and at risk of malnutrition recruited from several nursing homes in this study. Participants were divided into two groups: an NE group (n = 50) and an NSD group (n = 57). The NE group was given NE by a dietitian, while the NSD group was provided with two packs of NSD except receiving NE (Mei Balance, Meiji Holdings, Tokyo, Japan) per day as a snack between meals and before bed. Anthropometric data, blood pressure, nutritional status, blood biochemical biomarkers, and physical performance were measured before and after 12-week interventions. After 12 weeks of NE combined with NSD intervention, body weight, body-mass index, the mini nutritional assessment-short form (MNA-SF) score, walking speed, and SF-36 questionnaire score were improved in older nursing home residents at risk of malnutrition. Full article
(This article belongs to the Special Issue Dietary Management and Nutritional Health for Age-Related Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

30 pages, 1925 KiB  
Review
Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging
by Quélita Cristina Pereira, Isabela Monique Fortunato, Fabricio de Sousa Oliveira, Marisa Claudia Alvarez, Tanila Wood dos Santos and Marcelo Lima Ribeiro
Nutrients 2024, 16(7), 1066; https://doi.org/10.3390/nu16071066 - 5 Apr 2024
Cited by 2 | Viewed by 2417
Abstract
In the aging process, physiological decline occurs, posing a substantial threat to the physical and mental well-being of the elderly and contributing to the onset of age-related diseases. While traditional perspectives considered the maintenance of life as influenced by a myriad of factors, [...] Read more.
In the aging process, physiological decline occurs, posing a substantial threat to the physical and mental well-being of the elderly and contributing to the onset of age-related diseases. While traditional perspectives considered the maintenance of life as influenced by a myriad of factors, including environmental, genetic, epigenetic, and lifestyle elements such as exercise and diet, the pivotal role of symbiotic microorganisms had been understated. Presently, it is acknowledged that the intestinal microbiota plays a profound role in overall health by signaling to both the central and peripheral nervous systems, as well as other distant organs. Disruption in this bidirectional communication between bacteria and the host results in dysbiosis, fostering the development of various diseases, including neurological disorders, cardiovascular diseases, and cancer. This review aims to delve into the intricate biological mechanisms underpinning dysbiosis associated with aging and the clinical ramifications of such dysregulation. Furthermore, we aspire to explore bioactive compounds endowed with functional properties capable of modulating and restoring balance in this aging-related dysbiotic process through epigenetics alterations. Full article
(This article belongs to the Special Issue Dietary Management and Nutritional Health for Age-Related Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop