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Gene-Nutrient Interactions and Precise Nutrition in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 1962

Special Issue Editor


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Guest Editor
Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Interests: body composition; metabolism; personalized nutritional assessment; hydration status; psychological profile
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Special Issue Information

Dear Colleagues,

The intricate interplay between genetic factors and nutrient intake has emerged as a pivotal aspect in understanding individualized approaches to nutrition and its impact on human health. This Special Issue delves into the dynamic field of gene–nutrient interactions and the burgeoning concept of precise nutrition, thus exploring the bidirectional relationship between genetic variations and dietary components. Advancements in genomic research have unveiled the myriad of genetic variations that influence an individual's response to specific nutrients, with nutrient absorption, metabolism, and utilization being affected. Recognizing these variations enables the customization of dietary recommendations tailored to an individual's unique genetic makeup, paving the way for the realization of precision nutrition.

This abstract also explores the potential ability of gene–nutrient interactions to prevent and manage various health conditions, ranging from metabolic disorders to chronic diseases. Precision nutrition holds the promise of optimizing health outcomes by tailoring dietary interventions to address genetic predispositions and promote personalized well-being.

Furthermore, this abstract discusses the role of cutting-edge technologies, such as genomic sequencing and metabolomics, in unraveling the complexities of gene–nutrient interactions. These tools provide valuable insights into the identification of biomarkers and the development of personalized nutrition strategies, facilitating a more nuanced understanding of the intricate relationship between genes and nutrients.

I invite authors to submit original research and review articles that address the transformative potential of integrating genetic information into nutritional recommendations, heralding a new era of personalized and precise nutrition for enhanced human health. As research continues to unravel the intricacies of gene–nutrient interactions, the translation of these findings into practical applications holds great promise for optimizing health outcomes on an individualized basis.

Prof. Dr. Antonino De Lorenzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrigenetics
  • nutrigenomics
  • body composition
  • precision nutrition
  • diet

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Published Papers (1 paper)

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Research

20 pages, 2910 KiB  
Article
Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population
by Maria Vranceanu, Lorena Filip, Simona-Codruța Hegheș, David de Lorenzo, Anamaria Cozma-Petruț, Timea Claudia Ghitea, Carmina Mariana Stroia, Roxana Banc, Oana Maria Mîrza, Doina Miere, Vasile Cozma and Daniela-Saveta Popa
Nutrients 2024, 16(16), 2652; https://doi.org/10.3390/nu16162652 - 11 Aug 2024
Viewed by 1663
Abstract
Obesity, a significant public health concern with high prevalence in both adults and children, is a complex disorder arising from the interaction of multiple genes and environmental factors. Advances in genome-wide association studies (GWAS) and sequencing technologies have identified numerous polygenic causes of [...] Read more.
Obesity, a significant public health concern with high prevalence in both adults and children, is a complex disorder arising from the interaction of multiple genes and environmental factors. Advances in genome-wide association studies (GWAS) and sequencing technologies have identified numerous polygenic causes of obesity, particularly genes involved in hunger, satiety signals, adipocyte differentiation, and energy expenditure. This study investigates the relationship between six obesity-related genes (CLOCK, FTO, GHRL, LEP, LEPR, MC4R) and their impact on BMI, WC, HC, WHR, and emotional eating behavior in 220 Romanian adults. Emotional eating was assessed using the validated Emotional Eating Questionnaire (EEQ). Our analysis revealed significant variability in obesity-related phenotypes and emotional eating behaviors across different genotypes. Specifically, CLOCK/CC, FTO/AA, and LEP/AA genotypes were strongly associated with higher obesity metrics and emotional eating scores, while GHRL/TT and MC4R/CC were linked to increased BMI and WHR. The interplay between genetic predisposition and emotional eating behavior significantly influenced BMI and WHR, indicating a complex relationship between genetic and behavioral factors. This study, the first of its kind in Romania, provides a foundation for targeted interventions to prevent and reduce obesity and suggests potential strategies for gene expression modulation to mitigate the effects of emotional eating. Adopting a ‘One Health’ approach by creating an evidence base derived from both human and animal studies is crucial for understanding how to control obesity. Full article
(This article belongs to the Special Issue Gene-Nutrient Interactions and Precise Nutrition in Human Health)
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