Managing Nonalcoholic Fatty Liver Disease with Nutrition
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".
Deadline for manuscript submissions: 25 December 2024 | Viewed by 308
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to announce the Special Issue “Managing Nonalcoholic Fatty Liver Disease with Nutrition”. Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD) in the Delphi consensus statement, has been increasing worldwide with global obesity trends and become a major health problem, potentially leading to cardiovascular or liver-related mortality. To overcome this threat to humanity, efficacious therapeutic methods need to be urgently established.
Although resmetirom, the first agent approved for NAFLD, has marked the beginning of drug therapy for NAFLD, nutrition therapy is still the most fundamental treatment. Of the nutritional approaches, energy intake control is the first step in managing NAFLD. Besides the powerful effect of energy restriction on reversing NAFLD stages, chrono-nutrition, a novel nutrition field, has revealed that energy intake in line with circadian rhythm can restore and/or maintain homeostasis, resulting in the prevention of obesity and metabolic syndrome, conditions strongly linked to NAFLD. Next, appropriate nutrient intake is the key to successful management of NAFLD. Nutrients include carbohydrates, lipids, proteins, vitamins, minerals, dietary fiber, and phytochemicals. Many studies have indicated that the Mediterranean diet, containing lots of polyunsaturated fatty acids, vitamins, dietary fiber, and phytochemicals, is preferred for patients with NAFLD. There is abundant evidence that vitamin E supplementation can alleviate NAFLD. In contrast, excessive fructose, saturated fatty acid, and animal protein intake has been reported to increase the risk for NAFLD. Finally, nutrigenetics and nutriepigenetics will increasingly contribute to personalized medicine for NAFLD. For example, individuals with some genetic polymorphisms, such as PNPLA3 and TM6SF2 variants, are vulnerable to health problems due to overnutrition, and thus are at a high risk for NAFLD. Furthermore, recent studies have shown that early-life nutrition may be a determinant of later NAFLD because it can influence metabolism-related gene expression through epigenetic changes.
This Special Issue aims to provide an opportunity for researchers and clinicians to share cutting-edge knowledge concerning nutrition therapy for NAFLD. Original research articles and reviews are welcome. Research areas may include (but not limited to) the following: molecular nutrition; nutrigenetics and nutriepigenetics; and novel nutrition fields.
Dr. Nobuyuki Toshikuni
Guest Editor
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Keywords
- nonalcoholic fatty liver disease
- nutrition therapy
- energy intake
- chrono-nutrition
- nutrients
- Mediterranean diet
- nutrigenetics
- nutriepigenetics
- personalized medicine
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