Effects and Modulatory Mechanisms of Dietary Flavonoids in Obesity
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".
Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 1128
Special Issue Editors
Interests: functional foods; antioxidant activity; cell culture; metabolic diseases; apoptosis; molecular biology; biological sciences
Special Issues, Collections and Topics in MDPI journals
Interests: functional foods; dietary bioactive compounds; nutrigenomics; antioxidant activity; anticancer potential; chemoprevention; anti-inflammatory effects; obesity; inflammatory bowel disease; endometriosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The epidemic of obesity and accompanying metabolic complications is growing rapidly worldwide. Obesity is associated with adipose tissue hypertrophy, which refers to the increase in cellular lipid content, and hyperplasia, which depends on differentiation from preadipocytes. Hyperplasia takes place through adipogenesis and involves a cascade of transcriptional factors and cell cycle proteins, leading to the development of mature adipocytes. This process can be divided into three main phases: growth arrest, clonal expansion, and terminal differentiation. The inhibition of adipogenesis occurs when any of these stages are interrupted, which may serve as a potential therapeutic strategy against obesity. Furthermore, the hypertrophy of existing adipocytes, through excessive fat accumulation, leads to chronic inflammation, oxidative stress, and dysregulated adipokine secretion. These pathogenic abnormalities initiate metabolic and immune responses that promote the development of metabolic disorders. Dietary flavonoids have become the subject of increasing scientific interest due to their effects on adipogenesis. Flavonoids have been shown to regulate several pathways and affect several molecular targets during specific stages of adipocyte development. Moreover, flavonoids have been found to be a valuable dietary ingredient for mitigating adverse metabolic consequences of fat cell hypertrophy, thus reducing the risk of metabolic disorders.
The Special Issue will publish original research articles and reviews on the effects of dietary flavonoids on adipocyte hyperplasia and hypertrophy and the mechanisms of action and discuss their implications for human health.
Dr. Katarzyna Kowalska
Dr. Anna Olejnik
Guest Editors
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Keywords
- adipogenesis
- dietary flavonoids
- obesity
- hyperplasia
- hypertrophy
- adipocyte differentiation
- adipokines
- anti-adipogenic
- oxidative stress
- inflammation
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