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Perinatal Nutrition Interventions
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Perinatal Nutrition Interventions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 28857

Special Issue Editors

Prof. Dr. Umberto Simeoni

E-Mail Website
Guest Editor
Department Woman-Mother-Child, DOHaD Laboratory and Division of Pediatrics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Interests: pediatrics; newborn infant; nutrition; DOHaD
Dr. Céline J. Fischer Fumeaux

E-Mail Website
Guest Editor
Clinic of Neonatology, Department Woman Mother Child, University Hospital of Lausanne, 1011 Lausanne, Switzerland
Interests: neonatology; nutrition; human milk; preterm infants

Special Issue Information

Dear Colleagues,

The normal progress of pregnancy and the first phases of infant development are achieved through major nutritional adaptations, both in the mother and in the offspring. In pregnancies complicated by major perinatal syndromes such as prematurity, pre-eclampsia, restricted fetal growth, maternal metabolic disorders, and inflammatory syndromes, nutrition is a decisive factor, involved in their causes as well as in their consequences.

Converging results of epidemiological, clinical, and experimental studies show that, beyond the short-term mortality and morbidity caused by perinatal complications, the long-term health of the mother and that of the child until adulthood are influenced by the early environment, in particular by nutrition. Nutrition and the various components of stress modulate the developmental programming of major physiologic and biologic functions, including the control of senescence, in the offspring. Environmental exposures during the preconception period, the lifestyles of both the future father and the future mother, have received particular attention, given the potential of influencing the risk of later disease through early prevention based on nutrition and lifestyle interventions. Continuing progress is being made in our understanding of the fundamental mechanisms of the development of health or disease over the lifespan and the reproduction cycles. Today, our expanding knowledge on the epigenetic imprinting of the interactions between environment and genome during the perinatal period strongly suggests that early prevention has transgenerational effects in a number of situations. Thus, this period represents a critical “window of opportunity” for lifelong effective interventions.

This special issue of Nutrients on perinatal nutrition interventions welcomes submissions of original research studies (clinical, epidemiological, or fundamental), reviews, and meta-analyses, with the aim of further improving and sharing the knowledge on nutrition surrounding the process of reproduction. Contributions may relate to the field of nutrition in normal pregnancy and birth, as well as situations of perinatal complications, including hyperglycemia in pregnancy, maternal weight disorders, and the nutrition of preterm and intra-uterine growth-restricted infants.

Prof. Dr. Umberto Simeoni
Dr. Céline J. Fischer Fumeaux
Guest Editors

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Keywords

  • Periconception and perinatal health
  • Nutrition
  • Maternal, fetal, neonatal nutrition
  • Long-term impact of early nutrition

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Published Papers (7 papers)

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Research

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14 pages, 1782 KiB  
Article
Human Milk Oligosaccharides Are Present in Amniotic Fluid and Show Specific Patterns Dependent on Gestational Age
by Evelyn Jantscher-Krenn, Lara von Schirnding, Martin Trötzmüller, Harald Köfeler, Una Kurtovic, Herbert Fluhr, Andreas Müller and Soyhan Bagci
Nutrients 2022, 14(10), 2065; https://doi.org/10.3390/nu14102065 - 14 May 2022
Cited by 7 | Viewed by 5113
Abstract
(1) Background: Human milk oligosaccharides (HMOs) are already found in maternal circulation in early pregnancy, changing with gestational age. HMOs are also present in cord blood and amniotic fluid (AF). We aimed to assess HMO profiles in AF over the course of gestation. [...] Read more.
(1) Background: Human milk oligosaccharides (HMOs) are already found in maternal circulation in early pregnancy, changing with gestational age. HMOs are also present in cord blood and amniotic fluid (AF). We aimed to assess HMO profiles in AF over the course of gestation. (2) Methods: AF was collected during diagnostic amniocentesis, fetal surgery, or C-section from 77 women with a gestational age of ranging from 14.3 to 40.9 weeks. Samples were analysed using high performance liquid chromatography with fluorescence detection. (3) Results: We found lactose and up to 16 HMO structures in all AF samples investigated, starting at 14 weeks of gestation. Overall, 3′-sialyllactose (3′SL) and 2′-fucosyllactose (2′FL) were the most abundant HMOs. Individual and total HMO concentrations were significantly positively correlated with gestational age. HMO composition also changed between early, mid- and late pregnancy, with relative concentrations of 3′SL significantly decreasing (44%, 25%, 24%) and 2′FL increasing (7%, 13%, 21%), respectively. (4) Conclusion: Our study shows that HMOs are already present in AF early in pregnancy. This demonstrates extensive contact of the fetus with a broad variety of HMOs, suggesting roles for HMOs in fetal tissue development during the time course of pregnancy. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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13 pages, 300 KiB  
Article
A Community Prenatal Intervention in Social Nutrition: Evaluating the Impact on Pregnancy and Birthweight Outcomes
by Elise Carbonneau, Alex Dumas, Annie Brodeur-Doucet and Bénédicte Fontaine-Bisson
Nutrients 2022, 14(6), 1151; https://doi.org/10.3390/nu14061151 - 9 Mar 2022
Cited by 3 | Viewed by 3200
Abstract
This study aims to assess the associations between structural features of the Montreal Diet Dispensary’s social nutrition intervention and pregnancy (i.e., anemia, gestational diabetes mellitus (GDM), gestational weight gain (GWG), hypertension) and birthweight outcomes (i.e., small- or large-for-gestational-age) among pregnant women, most of [...] Read more.
This study aims to assess the associations between structural features of the Montreal Diet Dispensary’s social nutrition intervention and pregnancy (i.e., anemia, gestational diabetes mellitus (GDM), gestational weight gain (GWG), hypertension) and birthweight outcomes (i.e., small- or large-for-gestational-age) among pregnant women, most of them recent immigrants. The study consists of a secondary analysis of the digital client database of the Montreal Diet Dispensary (n = 2925). Logistic regressions were used to estimate the odds of pregnancy and birthweight outcomes, depending on structural features of the intervention. Pregnant women who attended a welcoming group session presented lower odds of GDM and anemia compared to those who did not attend. A longer duration of intervention was also associated with lower odds of GDM and anemia. Each additional appointment with a dietitian was associated with higher odds of excessive GWG and lower odds of insufficient GWG only among women with a pre-pregnancy BMI lower than 25 kg/m2. This study emphasizes the importance of providing nutritional services early in pregnancy to reduce the risk of GDM and anemia. It also stresses the importance of using appropriate nutritional guidelines to avoid increasing the risk of excessive GWG. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
10 pages, 659 KiB  
Article
A Positive Impact of an Observational Study on Breastfeeding Rates in Two Neonatal Intensive Care Units
by Sophie Laborie, Géraldine Abadie, Angélique Denis, Sandrine Touzet and Céline J. Fischer Fumeaux
Nutrients 2022, 14(6), 1145; https://doi.org/10.3390/nu14061145 - 8 Mar 2022
Cited by 5 | Viewed by 2038
Abstract
We aimed to investigate whether the participation in an observational study on breastfeeding (Doal) modified breastfeeding outcomes in enrolling neonatal intensive care units (NICUs). This bi-centric before-and-after study included neonates who were admitted during a 4-month period before and a 4-month [...] Read more.
We aimed to investigate whether the participation in an observational study on breastfeeding (Doal) modified breastfeeding outcomes in enrolling neonatal intensive care units (NICUs). This bi-centric before-and-after study included neonates who were admitted during a 4-month period before and a 4-month period after the implementation of Doal. Breastfeeding intention and breastfeeding rates at discharge were compared between the two periods. The association between inclusion in Doal and breastfeeding at discharge was assessed among the infants fulfilling the inclusion criteria of Doal. The present study included 655 neonates. After adjustments, both breastfeeding (aOR 1.21, 95%CI [1.1; 1.4], p = 0.001) and exclusive breastfeeding (aOR 1.8, 95%CI [1.4; 2.3], p < 0.001) at discharge increased in the period after. Breastfeeding intention was higher in one center in the period after (79%) compared to before (59%, p = 0.019). Compared to the period before, neonates who were not included in Doal in the period after had a lower chance to be breastfed at discharge, whereas those included were more frequently exclusively breastfed. The participation in an observational study on breastfeeding was associated with an increase in breastfeeding outcomes in enrolling neonatal intensive care units (NICUs). Patients who are not included deserve attention as they are at risk to be disadvantaged regarding breastfeeding success. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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14 pages, 2056 KiB  
Article
Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses
by Claudia Tonini, Marco Segatto, Simona Bertoli, Alessandro Leone, Arianna Mazzoli, Luisa Cigliano, Laura Barberio, Maurizio Mandalà and Valentina Pallottini
Nutrients 2021, 13(6), 1970; https://doi.org/10.3390/nu13061970 - 8 Jun 2021
Cited by 19 | Viewed by 3521
Abstract
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in several body fluids. [...] Read more.
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in several body fluids. The effects of this exposure on the fetus are under active investigation in several research laboratories. The aim of our work was to study the impact of prenatal exposure to BPA in the liver of rat fetuses from a sex-dependent point of view. We particularly investigated the effects of prenatal BPA exposure on hepatic lipids because of their crucial role, not only for the liver, but also for the whole-body functions. Our results demonstrate that the liver of rat fetuses, in utero exposed to a very low dose of BPA (2.5 µg/kg/day), displays significant modulations with regard to proteins involved in cholesterol and fatty acid biosynthesis and trafficking. Moreover, an impact on inflammatory process has been observed. All these effects are dependent on sex, being observable only in female rat fetuses. In conclusion, this work demonstrates that maternal exposure to BPA compromises hepatic lipid metabolism in female offspring, and it also reveals the perspective impact of BPA on human health at doses currently considered safe. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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14 pages, 782 KiB  
Article
Effect of a Low-Glycemic Load Diet Intervention on Maternal and Pregnancy Outcomes in Obese Pregnant Women
by Janina Goletzke, Jessica De Haene, Naomi E. Stotland, Elizabeth J. Murphy, Marcela Perez-Rodriguez and Janet C. King
Nutrients 2021, 13(3), 748; https://doi.org/10.3390/nu13030748 - 26 Feb 2021
Cited by 7 | Viewed by 3432
Abstract
The increased prevalence of obese, pregnant women who have a higher risk of glucose intolerance warrants the need for nutritional interventions to improve maternal glucose homeostasis. In this study, the effect of a low-glycemic load (GL) (n = 28) was compared to [...] Read more.
The increased prevalence of obese, pregnant women who have a higher risk of glucose intolerance warrants the need for nutritional interventions to improve maternal glucose homeostasis. In this study, the effect of a low-glycemic load (GL) (n = 28) was compared to a high-GL (n = 34) dietary intervention during the second half of pregnancy in obese women (body mass index (BMI) > 30 or a body fat >35%). Anthropometric and metabolic parameters were assessed at baseline (20 week) and at 28 and 34 weeks gestation. For the primary outcome 3h-glucose-iAUC (3h-incremental area under the curve), mean between-group differences were non-significant at every study timepoint (p = 0.6, 0.3, and 0.8 at 20, 28, and 34 weeks, respectively) and also assessing the mean change over the study period (p = 0.6). Furthermore, there was no statistically significant difference between the two intervention groups for any of the other examined outcomes (p ≥ 0.07). In the pooled cohort, there was no significant effect of dietary GL on any metabolic or anthropometric outcome (p ≥ 0.2). A post hoc analysis comparing the study women to a cohort of overweight or obese pregnant women who received only routine care showed that the non-study women were more likely to gain excess weight (p = 0.046) and to deliver large-for-gestational-age (LGA) (p = 0.01) or macrosomic (p = 0.006) infants. Thus, a low-GL diet consumed during the last half of pregnancy did not improve pregnancy outcomes in obese women, but in comparison to non-study women, dietary counseling reduced the risk of adverse outcomes. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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Review

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17 pages, 594 KiB  
Review
Studies to Improve Perinatal Health through Diet and Lifestyle among South Asian Women Living in Canada: A Brief History and Future Research Directions
by Dipika Desai, Sujane Kandasamy, Jayneel Limbachia, Michael A. Zulyniak, Paul Ritvo, Diana Sherifali, Gita Wahi, Sonia S. Anand and Russell J. de Souza
Nutrients 2021, 13(9), 2932; https://doi.org/10.3390/nu13092932 - 24 Aug 2021
Cited by 7 | Viewed by 5406
Abstract
South Asians (i.e., people who originate from India, Pakistan, Sri Lanka, Nepal, and Bangladesh) have higher cardiovascular disease rates than other populations, and these differences persist in their offspring. Nutrition is a critical lifestyle-related factor that influences fetal development, and infant and child [...] Read more.
South Asians (i.e., people who originate from India, Pakistan, Sri Lanka, Nepal, and Bangladesh) have higher cardiovascular disease rates than other populations, and these differences persist in their offspring. Nutrition is a critical lifestyle-related factor that influences fetal development, and infant and child health in early life. In high-income countries such as Canada, nutrition-related health risks arise primarily from overnutrition, most strikingly for obesity and associated non-communicable diseases. Evidence for developmental programming during fetal life underscores the critical influence of maternal diet on fetal growth and development, backed by several birth cohort studies including the Pune Maternal Nutrition Study, the South Asian Birth Cohort Study, and the Born in Bradford Study. Gestational diabetes mellitus is a strong risk factor for type 2 diabetes, future atherosclerosis and cardiovascular disease in the mother and increases the risk of type 2 diabetes in her offspring. Non-pharmacological trials to prevent gestational diabetes are few, often not randomized, and are heterogeneous with respect to design, and outcomes have not converged upon a single optimal prevention strategy. The aim of this review is to provide an understanding of the current knowledge around perinatal nutrition and gestational diabetes among the high-risk South Asian population as well as summarize our research activities investigating the role of culturally-tailored nutrition advice to South Asian women living in high-income settings such as Canada. In this paper, we describe these qualitative and quantitative studies, both completed and underway. We conclude with a description of the design of a randomized trial of a culturally tailored personalized nutrition intervention to reduce gestational glycaemia in South Asian women living in Canada and its implications. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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30 pages, 578 KiB  
Review
Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials
by Daria Masztalerz-Kozubek, Monika A. Zielinska-Pukos and Jadwiga Hamulka
Nutrients 2021, 13(7), 2302; https://doi.org/10.3390/nu13072302 - 4 Jul 2021
Cited by 13 | Viewed by 4637
Abstract
There is growing evidence that bone health may be programmed in the first years of life. Factors during the prenatal period, especially maternal nutrition, may have an influence on offspring’s skeletal development and thus the risk of osteoporosis in further life, which is [...] Read more.
There is growing evidence that bone health may be programmed in the first years of life. Factors during the prenatal period, especially maternal nutrition, may have an influence on offspring’s skeletal development and thus the risk of osteoporosis in further life, which is an increasing societal, health and economic burden. However, it is still inconclusive which early life factors are the most important and to what extent they may affect bone health. We searched through three databases (PubMed, Google Scholar, Cochrane Library) and after eligibility criteria were met, the results of 49 articles were analyzed. This narrative review is an overall summary of up-to-date studies on maternal diet, nutritional status, and birth-related factors that may affect offspring bone development, particularly bone mineral density (BMD). Maternal vitamin D status and diet in pregnancy, anthropometry and birth weight seem to influence BMD, however other factors such as subsequent growth may mediate these associations. Due to the ambiguity of the results in the analyzed studies, future, well-designed studies are needed to address the limitations of the present study. Full article
(This article belongs to the Special Issue Perinatal Nutrition Interventions)
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