Metal-Based Agents in Drug Discovery 2024
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (25 June 2024) | Viewed by 230
Special Issue Editor
Interests: medicinal chemistry; biologically active metal complexes; ligand–biomolecule interactions; molecular probes and sensors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the plethora of available therapeutics with various properties, we continue to struggle with many diseases, adverse drug reactions, and drug resistance. Therefore, new molecules that can be used as medical therapeutics are, and will always be, highly demanded. This irrefutably implies a necessity for constant studies on the chemotherapy and therapeutic agents, not only from the medical perspective but also as a challenge for the fundamental sciences.
The discovery and subsequent widespread use of cisplatin has placed transition metal coordination chemistry at the frontline in the fight against cancer. This has led, among others, to the exploration and synthesis of different drugs that are based on other metal ions, which can be very interesting from a medicinal point of view because inorganic and coordination chemistry offers additional opportunities for the design of therapeutic agents otherwise unavailable to organic chemistry. The wide range of coordination numbers and geometries, different available redox states and various thermodynamic and kinetic properties as well as the intrinsic properties of metal ions may result in a variety of interactions not possible for organic compounds.
Indeed, transition metal complexes can show antitumor, antibacterial, antifungal, antiviral, and anti-inflammatory activities, which result in their being promising and suitable candidates as drugs. Additionally, it is known that any structural modifications of chemotherapeutic agents or their interactions with metal ions, including ions that are present in the organism, can significantly affect their pharmacological effectiveness. The binding of metal ions to the available electron donor groups of applied drugs can affect both their activity, digestibility, and degree of toxicity.
In this Special Issue “Metal-Based Agents in Drug Discovery”, we wish to focus on not only the design, synthesis, and application of metal coordination compounds as therapeutic agents but also on the interactions of metal ions with drugs or cellular targets. Research articles, comprehensive reviews, and short communications are welcome. Our aim is to collect and present the most recent insights and results involving multidisciplinary approaches.
Dr. Radosław Starosta
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- medicinal inorganic chemistry
- medicinal coordination chemistry
- metal based drugs
- transition metal complexes
- coordination compounds
- antifungal properties
- antibacterial properties
- anticancer properties
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
