Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 106
Special Issue Editors
Interests: drug design and synthesis; medicinal chemistry; organic synthesis; antimicrobial agents; structure–activity relationship; antiviral agents; antiparasitic agents; anticancer agents; antiprotozoal agents
Special Issues, Collections and Topics in MDPI journals
Interests: synthesis of heterocycles; medicinal chemistry; organic chemistry; medicinal chemistry and drug design; medicinal chemistry CNS drug discovery and delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Most of the organic compounds used as therapeutics, as well as intermediates utilized for their synthesis, contain heterocyclic motifs. A heterocycle is a ring with at least one atom that is not carbon. Nitrogen, oxygen, and sulfur are the primary elements seen in common heterocycles, and they play a critical role in drug discovery. Furthermore, there are a plethora of natural products which are heterocycles that serve as the basis for many different substances, including alkaloids, vitamins, hormones, dyes, antibiotics, herbicides, or nutraceuticals. Over the past decades, much attention has been devoted to the development and pharmacological studies of heteroaromatic organic compounds that are currently considered privileged scaffolds for different therapeutic agents. Indeed, they are involved in a wide range of biological activities, representing nearly 60% of all FDA-approved drugs. This Special Issue will publish research papers with topics including, but not limited to, the preparation of aromatic and non-aromatic heterocycles endowed with any biological action. We also welcome contributions that highlight the importance of heterocyclic scaffolds that are widely found in agrochemicals, dyes, cosmetics, and functional materials. The aim of the present Special Issue is primarily to present an overview of the state-of-the-art synthetic methods and recent advances in the synthesis of heterocycles.
Dr. Valentina Noemi Madia
Dr. Davide Ialongo
Guest Editors
Manuscript Submission Information
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Keywords
- heterocycles
- drug design
- drug discovery
- bioactive compounds
- structure-based drug design
- structure–activity relationship
- in silico studies
- ADMET properties
- multicomponent reactions
- phytochemicals
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