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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antivirals and Targets to Fight RNA Viruses

edited by

Cristina Romero-López

and

Alfredo Berzal-Herranz

submission deadline 24 Jan 2025 | 1 articles | Viewed by 3818 | Submission Open

Keywords: RNA virus; antiviral; drug target; viral translation; RNA structure; viral replication

(This special issue belongs to the Section Biopharmaceuticals)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 25 Jan 2025 | 8 articles | Viewed by 18107 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health

edited by

Diego Morales

submission deadline 25 Jan 2025 | 8 articles | Viewed by 14530 | Submission Open

Keywords: plant bioactives; bioactive compounds; gut microbiome; immune-modulatory; antioxidant; hypocholesterolemic; antihypertensive; clinical trials

(This special issue belongs to the Section Natural Products)

20th Anniversary of Pharmaceuticals—Therapeutic Mechanisms of Nature Products against Insulin Resistance 2024

edited by

Anne-Dominique Lajoix

and

Didier Tousch

submission deadline 25 Jan 2025 | 3 articles | Viewed by 12107 | Submission Open

Keywords: insulin resistance; signaling pathways; liver; skeletal muscle; adipose tissues; traditional medicine; plants; fungus; algae; food ingredients

(This special issue belongs to the Section Natural Products)

Advances in Neuropharmacology of Drug Abuse

edited by

Stefania Chiappini

submission deadline 25 Jan 2025 | 3 articles | Viewed by 10460 | Submission Open

Keywords: neuropharmacology; drug abuse; addiction; substance abuse

(This special issue belongs to the Section Pharmacology)

Advanced Strategies in Drug Design and Development of Small Molecules as Therapeutic Agents

edited by

Fedora Grande

submission deadline 25 Jan 2025 | 7 articles | Viewed by 9619 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024

edited by

Cinzia Anna Ventura

and

Federica De Gaetano

submission deadline 25 Jan 2025 | 6 articles | Viewed by 9278 | Submission Open

Keywords: drug delivery; inclusion complexes; polymeric cyclodextrins; nanostructurated carriers; polyrotaxanes; nanosponges; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation; theranostic; regenerative medicine; gene delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Therapeutic Agents for the Treatment of Tumors in the CNS

edited by

Gautham Gampa

Sani H. Kizilbash

and

Shannon P. Fortin Ensign

submission deadline 25 Jan 2025 | 5 articles | Viewed by 8597 | Submission Open

Keywords: primary brain tumors; glioblastoma; brain metastases (BMs); neuro-oncology; blood– brain barrier (BBB); drug delivery; preclinical PK/PD; molecularly targeted agents; immunotherapy; new modalities

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 25 Jan 2025 | 5 articles | Viewed by 7361 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

Stem Cells and Organoids as Tools for Drug Development

edited by Daniela Omodei

submission deadline 25 Jan 2025 | 2 articles | Viewed by 3971 | Submission Open

Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine

(This special issue belongs to the Section Biopharmaceuticals)

Novel Treatments and Technologies for Retinal Diseases

edited by

Michael John Tolentino

submission deadline 25 Jan 2025 | 2 articles | Viewed by 3442 | Submission Open

Keywords: age-related macular degeneration; diabetic retinopathy; retinal degeneration; novel therapeutics; imaging biomarkers; artificial intelligence; clinical trials

(This special issue belongs to the Section Pharmaceutical Technology)

Bioactive Substances and Skin Health: The Role of Pharmacy and Nutrition—Properties and Technology

edited by

Francisco Rivas

, Margarita López-Viota and Rafael Jesús Giménez Martínez

submission deadline 25 Jan 2025 | 1 articles | Viewed by 3375 | Submission Open

Keywords: supplements; bioactive substances; skin health

(This special issue belongs to the Section Pharmaceutical Technology)

Modern Approach to Neuroendocrine Neoplasms Diagnosis and Treatment

edited by Marek Saracyn and

Adam Daniel Durma

submission deadline 25 Jan 2025 | 1 articles | Viewed by 2371 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); neuroendocrine tumors (NETs); non-invasive interventions; NEN surgery; somatostatin analogs; radioligand therapy (RLT; PRRT); NEN targeted therapy; NEN chemotherapy; NEN epidemiology; NEN treatment complications; [68Ga]Ga-PET/CT; [18F]FDG- PET/CT; [99mTc]-scintigraphy

(This special issue belongs to the Section Medicinal Chemistry)

Drug Candidates for the Treatment of Atopic Dermatitis

edited by

Hyun-Su Lee

submission deadline 25 Jan 2025 | 1 articles | Viewed by 1268 | Submission Open

Keywords: atopic dermatitis; skin barrier; skin disease; house-dust-mite-induced atopic dermatitis; small molecules for atopic dermatitis treatment

(This special issue belongs to the Section Pharmacology)

Exploring Marine-Derived Natural Products for Developing Drugs with Anticancer Effects

edited by Mei-Chin Lu and

Mohamed El-Shazly

submission deadline 25 Jan 2025 | Viewed by 469 | Submission Open

Keywords: drug discovery; marine-derived natural products; anticancer compounds; marine organisms; bioactivity; cancer treatment; biodiversity; pharmacological screening; novel therapeutics; natural product; chemistry

(This special issue belongs to the Section Natural Products)

Medications: Interactions with Diet, Herbs, Dietary Supplements and Probiotics

edited by

Francisco Rivas

, María Isabel Valverde Merino and Maria José Zarzuelo Romero

submission deadline 25 Jan 2025 | Viewed by 455 | Submission Open

Keywords: food– drug interactions; dietary supplements; probiotics; herb– drug interaction

(This special issue belongs to the Section Pharmacology)

Management of Pain in Oral Mucositis

edited by

Carlos Roldan

and Thomas Chai

submission deadline 25 Jan 2025 | Viewed by 147 | Submission Open

Keywords: oral mucositis; oral pain; pain management; cancer; cancer therapy

(This special issue belongs to the Section Pharmacology)

Recent Advances in the Pharmacology of Serotonin and Its Receptors, 2nd Edition

edited by

Elżbieta Żmudzka

and Kinga Sałaciak

submission deadline 25 Jan 2025 | Viewed by 141 | Submission Open

Keywords: serotonin; serotonergic system; serotonergic receptors; serotonin neurotransmission; central nervous system; neuropsychiatry; neuropharmacology; peripheral serotonin; gastrointestinal tract; preclinical studies; clinical studies

(This special issue belongs to the Section Pharmacology)

Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024

edited by

Geir Bjørklund

Mariia Shanaida

and

Olha Mykhailenko

submission deadline 31 Jan 2025 | 5 articles | Viewed by 10973 | Submission Open

Keywords: senescence; anti-aging compounds; natural products; medicinal plants; micronutrients; cosmetic ingredients; bioactive natural substances; antioxidant activity; pharmacological effect

(This special issue belongs to the Section Natural Products)

Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria

edited by

Adriána Liptáková

submission deadline 31 Jan 2025 | 5 articles | Viewed by 5659 | Submission Open

Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections

(This special issue belongs to the Section Pharmacology)

Novel Anti-proliferative Agents, 2nd Edition

edited by

Valentina Onnis

submission deadline 31 Jan 2025 | 3 articles | Viewed by 4181 | Submission Open

Keywords: medicinal chemistry; drug discovery; natural compounds; synthetic compounds; organic synthesis; bioactivity; anticancer drugs; antiproliferative activity

(This special issue belongs to the Section Medicinal Chemistry)

Preparation Technologies and Dissolution Behaviour of Oral Solids

edited by Paul Wan Sia Heng and Natalia Veronica

submission deadline 31 Jan 2025 | 1 articles | Viewed by 1990 | Submission Open

Keywords: granulation; oral solids; dissolution; sustain release; solubility; oral bioavailability

(This special issue belongs to the Section Pharmaceutical Technology)

Therapeutic Potential of Natural Products in the Treatment of Nervous System Diseases

edited by Zhen Tian

submission deadline 31 Jan 2025 | 2 articles | Viewed by 1732 | Submission Open

Keywords: natural products; nervous system diseases; drug discovery; neurodegeneration; neuroinflammation; chronic pain; neuropsychiatric disorders

(This special issue belongs to the Section Natural Products)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 31 Jan 2025 | 1 articles | Viewed by 1141 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Affective Disorders Psychopharmacology

edited by Danilo Arnone

submission deadline 31 Jan 2025 | 1 articles | Viewed by 1042 | Submission Open

Keywords: psychopharmacology; affective disorders; mood disorders; major depressive disorders; bipolar affective disorders

(This special issue belongs to the Section Pharmacology)

Osteosarcomas: Treatment Strategies, 2nd Edition

edited by

See-Hyoung Park

submission deadline 31 Jan 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: osteosarcoma; anti-cancer; apoptosis; natural compounds; target; drug

(This special issue belongs to the Section Pharmacology)

Innovative Approaches to Radiopharmaceuticals: Advances in Design, Labeling, and Applications

edited by Shvan J. Raheem and

Justin J. Bailey

submission deadline 31 Jan 2025 | Viewed by 300 | Submission Open

Keywords: radiochemistry; radiopharmaceutical; radiotracers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development

edited by

Giusy Tassone

Ilaria D'Agostino

and

Samuele Maramai

submission deadline 31 Jan 2025 | Viewed by 272 | Submission Open

Keywords: Hsp90; drug discovery; synthesis; chaperone; therapeutic potential; cancer treatment; neurodegenerative diseases; infection resistance mechanisms; research advancements; therapeutic development

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Targets and Therapies for the Treatment of Oral Cancer and Oral Diseases

edited by

Maria Eleonora Bizzoca

submission deadline 31 Jan 2025 | Viewed by 220 | Submission Open

Keywords: oral cancer; oral and maxillofacial surgery; oral and maxillofacial pathology medicine; periodontics and oral pathology; immunohistochemistry

(This special issue belongs to the Section Pharmacology)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova

submission deadline 31 Jan 2025 | Viewed by 214 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Natural Products-Assisted Organic Synthesis in Medicinal Chemistry

edited by

Natalia Miklášová

and

Eva Fischer-Fodor

submission deadline 31 Jan 2025 | Viewed by 166 | Submission Open

Keywords: total organic synthesis; preparative methods of natural products; natural carboxylic acids; derivatives of organic carboxylic acids; amino acids; carbonyl derivatives; phenolic compounds; heterocyclic compounds; antioxidant activity; antifungal activity; antimicrobial activity; anti-inflammatory activity; cytotoxicity; anti-cancer activity; ROS activity; DNA damages; structure-activity studies; DFT calculations for synthetic organic products; molecular docking

(This special issue belongs to the Section Medicinal Chemistry)

Bone Disorder Therapeutics: Novel Drug Candidates and Treatment Strategies

edited by

Mahdi Rahimi

submission deadline 31 Jan 2025 | Viewed by 150 | Submission Open

Keywords: bone health; osteoporosis; arthritis; osteoarthritis; bone cancer; regeneration; repair; metabolism; gene therapy; cell therapy

(This special issue belongs to the Section Pharmacology)

Recent Advances in Modulating Mitophagy with Novel Drugs/Compounds

edited by

Mingchong Yang

submission deadline 5 Feb 2025 | Viewed by 121 | Submission Open

Keywords: heart disease; mitochondria; mitophagy; mitochondrial quality control; drug screening

(This special issue belongs to the Section Pharmacology)

New Street Opioids, Their Mixtures and Emerging Interventions

edited by Michael V. Voronkov

submission deadline 10 Feb 2025 | Viewed by 215 | Submission Open

Keywords: fentanyl; naloxone; xylazine; nitazenes; opioid overdose; addiction; polypharmacology; polypharmacy; animal models

(This special issue belongs to the Section Pharmacology)

Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets

edited by

Anna Artese

submission deadline 15 Feb 2025 | 5 articles | Viewed by 7864 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Applications of Beehive Products for Wound Repair and Skin Care

edited by Simona Martinotti

submission deadline 15 Feb 2025 | Viewed by 224 | Submission Open

Keywords: anti-aging; antibacterial properties; healing properties; honey; propolis; bee venom; wound repair; skin care

(This special issue belongs to the Section Natural Products)

Recent Advances in TGF-β Inhibitors for the Therapeutic Management of Cancer and Fibrosis

edited by

David Danielpour

submission deadline 20 Feb 2025 | 8 articles | Viewed by 31133 | Submission Open

Keywords: TGF-β ; metastasis; EMT; immunotherapy; fibrosis; Smad2; Smad3; angiogenesis; ligand traps; soluble receptors

(This special issue belongs to the Section Pharmacology)

Transient Receptor Potential (TRP) Channels as Novel Therapeutic Targets

edited by

Dana Cucu

submission deadline 20 Feb 2025 | 12 articles | Viewed by 20965 | Submission Open

Keywords: TRP channels; signalling pathways; tumoral process; pain; migration; apoptosis; inflammation; oxidative stress

(This special issue belongs to the Section Pharmacology)

New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 20 Feb 2025 | 5 articles | Viewed by 12218 | Submission Open

Keywords: infectious diseases; antimicrobial resistance; parasites; viruses; bacteria; treatment approaches; therapeutics; chemotherapy; targeted drug design; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Antiradical, Chemopreventive and Antimicrobial Effects of Bioactive Natural Substances

edited by

Grażyna Zgórka

submission deadline 20 Feb 2025 | 5 articles | Viewed by 9263 | Submission Open

Keywords: natural radical scavengers; chemopreventive agents; antimicrobials; chemical and biomedical analysis; biological studies in vitro/in vivo

(This special issue belongs to the Section Natural Products)

The Role of Bioactive Compounds in the Prevention of Rheumatoid Arthritis

edited by

Luís Silva

submission deadline 20 Feb 2025 | 3 articles | Viewed by 6821 | Submission Open

Keywords: bioactive compounds; functional foods; nutraceuticals; rheumatoid arthritis; anti-inflamatory activity; anti-inflammatory mediators

(This special issue belongs to the Section Natural Products)

Natural Products in Health Promotion and Disease Prevention 2024

edited by

Marco G. Alves

and

Ariane Zamoner

submission deadline 20 Feb 2025 | 6 articles | Viewed by 5671 | Submission Open

Keywords: natural products; nutraceuticals; bioactive compounds; traditional medicine; drug discovery

(This special issue belongs to the Section Natural Products)

Recent Advances in Inhalation Therapy

edited by

Luca Casula

and

Francesco Lai

submission deadline 20 Feb 2025 | 1 articles | Viewed by 3575 | Submission Open

Keywords: inhalation therapy; pulmonary delivery; aerosols; dry powder inhalation; inhalable micro and nanoparticles; pulmonary deposition

(This special issue belongs to the Section Pharmaceutical Technology)

Targeted Therapies for Epilepsy

edited by

Giuseppe Biagini

Anna-Maria Costa

and Chiara Lucchi

submission deadline 20 Feb 2025 | 3 articles | Viewed by 3335 | Submission Open

Keywords: epilepsy; temporal lobe epilepsy; neurological disorder; spontaneous recurrent seizures; epileptogenesis; antiepileptogenic medications; antiseizure medications; drug-resistant epilepsy; adverse effects; drug discontinuation

(This special issue belongs to the Section Pharmacology)

Nano-Strategies in Fighting Cancer

edited by Ahmad Sohrabi Kashani and

Muthukumaran Packirisamy

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2702 | Submission Open

Keywords: nanomedicines; targeted therapy; intracellular diagnosis; cell mechanics; nano-biosensor; nano-bio interaction; mechanobiology; nano-biomechanics; drug delivery; migration

(This special issue belongs to the Section Medicinal Chemistry)

Tumor Therapy and Drug Delivery

edited by

Rositsa Mihaylova

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2598 | Submission Open

Keywords: antitumor therapy; drug delivery systems; nanocarriers; immunoconjugates; nanotechnology; cancer selectivity

(This special issue belongs to the Section Pharmaceutical Technology)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2213 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Pharmacotherapy of Neuropathic Pain

edited by

Marucia Chacur

submission deadline 20 Feb 2025 | 1 articles | Viewed by 1394 | Submission Open

Keywords: analgesic; inflammation; neurotransmitters; neuroplasticity; targeted therapies; neurogenic pain; opioids; cannabinoids

(This special issue belongs to the Section Pharmacology)

Novel Therapeutics in Hematology

edited by

Eleni Gavriilaki

submission deadline 20 Feb 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies

(This special issue belongs to the Section Pharmacology)

Advances in Peptide Chemistry and Medicinal Application

edited by

Santo Previti

submission deadline 20 Feb 2025 | Viewed by 300 | Submission Open

Keywords: peptide-based compounds; peptidomimetics; drug discovery; drug-like properties; target modulation; structure– activity relationship studies; unnatural amino acids; backbone modifications; antibodies; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

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