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Pharmaceutics
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Research on the Development of Nano-Based Polymeric Films for Drugs...
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Research on the Development of Nano-Based Polymeric Films for Drugs and Their Derivatives

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 4223

Special Issue Editors

Prof. Dr. André Ricardo Fajardo

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Guest Editor
Lab Tecnol & Desenvolvimento Compositos & Mat Poli, Univ Fed Pelotas UFPel, Campus Capao do Leao S-N, Pelotas BR-96010900, RS, Brazil
Interests: biopolymers; polysaccharides; polymer materials; polymer composites; hydrogels; biomaterials; delivery systems; hydrid materials; responsible materials; chitosan; starch; alginate; pectin; glycosaminoglycans
Prof. Dr. Luana Mota Ferreira

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Guest Editor
Pharmacy Department, Postgraduate Program of Pharmaceutical Sciences, Federal University of Paraná, UFPR, Curitiba, PR 80210-170, Brazil
Interests: pharmaceutical dosages; nanotechnology; natural polysaccharides; skin disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Marcel Henrique Marcondes Sari

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Guest Editor
Postgraduate Program of Pharmaceutical Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS 97105-900, Brazil
Interests: nano-based formulations; cutaneous drug delivery; inflammation; polymeric films;topical drug delivery; hydrogels.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric films are versatile forms that present a vast broad of applications, including therapeutic and cosmetic purposes, wound dressing, and intelligent packaging. Multiple materials are studied for preparing polymeric films, from those of synthetic to even natural origin, such as polysaccharides. Remarkably, the solid state of polymeric films positively influences their physicochemical and microbiological stability as well as allows the application by multiple administration routes, e.g. cutaneous, oral, and vaginal, among others. Recently, the association of nanocarriers with polymeric films has been investigated given the potentialities attributed to nanotechnological-based formulations, including controlled drug release, reduced toxicity, increased adhesiveness, permeation through biological barriers and pharmacological actions. In this sense, nano-based polymeric films may represent a promising alternative for numerous purposes. Thus, this Special Issue aims to address studies approaching the development, characterization, and biological evaluation of nanotechnological-based polymeric films. Potential new uses and novel formulations of polymeric films are welcome, mainly exploring the use of biodegradable and biocompatible materials.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: nano-based polymeric films, natural gums or other natural agents as film forming materials, toxicological aspects of polymeric films associated with nanocarriers (hard and soft-particles), pharmacological evaluation of nano-based polymeric films containing drugs and their derivatives, and films for personal care.

We look forward to receiving your contributions.

Prof. Dr. André Ricardo Fajardo
Prof. Dr. Luana Mota Ferreira
Dr. Marcel Henrique Marcondes Sari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric films
  • nanocarriers
  • natural gums
  • polysaccharides
  • skin
  • drug delivery

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Published Papers (3 papers)

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Research

23 pages, 4533 KiB  
Article
Exploring Cationic Guar Gum: Innovative Hydrogels and Films for Enhanced Wound Healing
by Kamila Gabrieli Dallabrida, Willer Cezar Braz, Crisleine Marchiori, Thainá Mayer Alves, Luiza Stolz Cruz, Giovanna Araujo de Morais Trindade, Patrícia Machado, Lucas Saldanha da Rosa, Najeh Maissar Khalil, Fabiane Gomes de Moraes Rego, André Ricardo Fajardo, Luana Mota Ferreira, Marcel Henrique Marcondes Sari and Jéssica Brandão Reolon
Pharmaceutics 2024, 16(9), 1233; https://doi.org/10.3390/pharmaceutics16091233 - 22 Sep 2024
Cited by 1 | Viewed by 1024
Abstract
Background/Objectives: This study developed and characterized hydrogels (HG-CGG) and films (F-CGG) based on cationic guar gum (CGG) for application in wound healing. Methods: HG-CGG (2% w/v) was prepared by gum thickening and evaluated for pH, stability, spreadability, and viscosity. F-CGG [...] Read more.
Background/Objectives: This study developed and characterized hydrogels (HG-CGG) and films (F-CGG) based on cationic guar gum (CGG) for application in wound healing. Methods: HG-CGG (2% w/v) was prepared by gum thickening and evaluated for pH, stability, spreadability, and viscosity. F-CGG was obtained using an aqueous dispersion of CGG (6% w/v) and the solvent casting method. F-CGG was characterized for thickness, weight uniformity, morphology, mechanical properties, hydrophilicity, and swelling potential. Both formulations were evaluated for bioadhesive potential on intact and injured porcine skin, as well as antioxidant activity. F-CGG was further studied for biocompatibility using hemolysis and cell viability assays (L929 fibroblasts), and its wound-healing potential by the scratch assay. Results: HG-CGG showed adequate viscosity and spreadability profiles for wound coverage, but its bioadhesive strength was reduced on injured skin. In contrast, F-CGG maintained consistent bioadhesive strength regardless of skin condition (6554.14 ± 540.57 dyne/cm2 on injured skin), presenting appropriate mechanical properties (flexible, transparent, thin, and resistant) and a high swelling capacity (2032 ± 211% after 6 h). F-CGG demonstrated superior antioxidant potential compared to HG-CGG (20.50 mg/mL ABTS+ radical scavenging activity), in addition to exhibiting low hemolytic potential and no cytotoxicity to fibroblasts. F-CGG promoted the proliferation of L929 cells in vitro, supporting wound healing. Conclusions: Therefore, CGG proved to be a promising material for developing formulations with properties suitable for cutaneous use. F-CGG combines bioadhesion, antioxidant activity, biocompatibility, cell proliferation, and potential wound healing, making it promising for advanced wound treatment. Full article
(This article belongs to the Special Issue Research on the Development of Nano-Based Polymeric Films for Drugs and Their Derivatives)
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19 pages, 4998 KiB  
Article
The Development and Pre-Clinical Anti-Inflammatory Efficacy of a New Transdermal Ureasil–Polyether Hybrid Matrix Loaded with Flavonoid-Rich Annona muricata Leaf Extract
by Camila Beatriz Barros Araújo, José de Oliveira Alves Júnior, Mariana Rillo Sato, Kammila Martins Nicolau Costa, Jéssica Roberta Lima, Bolívar Ponciano Goulart de Lima Damasceno, Francisco José Batista de Lima Junior, Bruna Galdorfini Chiari Andréo, Vanda Lucia dos Santos and João Augusto Oshiro-Junior
Pharmaceutics 2024, 16(8), 1097; https://doi.org/10.3390/pharmaceutics16081097 - 21 Aug 2024
Viewed by 757
Abstract
This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The extract was obtained by maceration, a method that allowed for the extraction of a high concentration of flavonoids [...] Read more.
This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The extract was obtained by maceration, a method that allowed for the extraction of a high concentration of flavonoids (39.27 mg/g of extract). In vivo tests demonstrated that 10 mg/kg of AMCE inhibited inflammation for 6 h. The physicochemical characterization of U-PEO with AMCE was conducted via a thermogravimetric analysis (TGA), while its surface was recorded using atomic force microscopy (AFM). The in vitro macroscopic swelling and release tests demonstrated the hydrophilic profile of the material and the percentage of AMCE released. The TGA results demonstrated that the system exhibited physical compatibility due to the thermal stability of U-PEO. Additionally, the AFM analysis revealed a rough and porous surface, with a particular emphasis on the system with AMCE. The release resulted in the liberation of 23.72% of AMCE within 24 h. Finally, the preclinical tests demonstrated that U-PEO with AMCE was also capable of effectively inhibiting inflammation for 6 h, a duration comparable to that of a commercial formulation. The results permit the advancement of the study towards the development of a transdermal system, thereby rendering its application in clinical studies feasible. Full article
(This article belongs to the Special Issue Research on the Development of Nano-Based Polymeric Films for Drugs and Their Derivatives)
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24 pages, 4876 KiB  
Article
Karaya/Gellan-Gum-Based Bilayer Films Containing 3,3′-Diindolylmethane-Loaded Nanocapsules: A Promising Alternative to Melanoma Topical Treatment
by Jéssica Brandão Reolon, Camila Parcianello Saccol, Bárbara Felin Osmari, Daiane Britto de Oliveira, Vinicius Costa Prado, Fernanda Licker Cabral, Lucas Saldanha da Rosa, Giancarlo Cervo Rechia, Daniela Bitencourt Rosa Leal and Letícia Cruz
Pharmaceutics 2023, 15(9), 2234; https://doi.org/10.3390/pharmaceutics15092234 - 29 Aug 2023
Cited by 6 | Viewed by 1698
Abstract
This study aimed to incorporate nanocapsules containing 3,3′-diindolylmethane (DIM) with antitumor activity into a bilayer film of karaya and gellan gums for use in topical melanoma therapy. Nanocarriers and films were prepared by interfacial deposition of the preformed polymer and solvent casting methods, [...] Read more.
This study aimed to incorporate nanocapsules containing 3,3′-diindolylmethane (DIM) with antitumor activity into a bilayer film of karaya and gellan gums for use in topical melanoma therapy. Nanocarriers and films were prepared by interfacial deposition of the preformed polymer and solvent casting methods, respectively. Incorporating DIM into nanocapsules increased its antitumor potential against human melanoma cells (A-375) (IC50 > 24.00 µg/mL free DIM × 2.89 µg/mL nanocapsules). The films were transparent, hydrophilic (θ < 90°), had homogeneous thickness and weight, and had a DIM content of 106 µg/cm2. Radical ABTS+ scavenger assay showed that the DIM films presented promising antioxidant action. Remarkably, the films showed selective bioadhesive potential on the karaya gum side. Considering the mechanical analyses, the nanotechnology-based films presented appropriate behavior for cutaneous application and controlled DIM release profile, which could increase the residence time on the application site. Furthermore, the nanofilms were found to increase the permeation of DIM into the epidermis, where melanoma develops. Lastly, the films were non-hemolytic (hemolysis test) and non-irritant (HET-CAM assay). In summary, the combination of karaya and gellan gum in bilayer films that contain nanoencapsulated DIM has demonstrated potential in the topical treatment of melanoma and could serve as a viable option for administering DIM for cutaneous melanoma therapy. Full article
(This article belongs to the Special Issue Research on the Development of Nano-Based Polymeric Films for Drugs and Their Derivatives)
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